Toby L. Simon, MD is senior medical director for plasma and plasma safety with CSL Plasma and in Research and Development for the parent company CSL Behring, He is past-president of AABB and America’s Blood Centers. He has been on the faculty of University of New Mexico School of Medicine (currently clinical faculty), medical director of TriCore Reference Laboratories and industry representative of the FDA Blood Products Advisory Committee.

Eric A. Gehrie, MD is a clinical pathologist who specializes in blood banking/transfusion medicine. He has been on the faculty of Yale and Johns Hopkins University Schools of Medicine and is currently Executive Physician Director for Direct Patient Care and Emerging Offerings at the American Red Cross. He is a member of the editorial board of Transfusion.

Jeffrey McCullough, MD is professor emeritus at the University of Minnesota Medical School with experience in both hospital transfusion services and blood centers. He was the editor of Transfusion for 15 years and the founding president of the US National Marrow Donor Program. He is currently an international advisor in transfusion medicine He is past-president of the American Board of Pathology.

John D. Roback, MD PhD is a Professor in the Department of Pathology and Laboratory Medicine at Emory University. His appointments include Medical Director of Emory Medical Laboratories, Emory/Children’s Laboratory for Innovative Assay Development, and the Center for Transfusion and Cellular Therapies. He is also Executive Vice-Chair of Clinical Operations. He is a former editor of the AABB Technical Manual.

Edward L. Snyder, MD is Professor of Laboratory Medicine and Attending Physician in the Transfusion and Tissue Services at Yale Medical School/ Yale New Haven Hospital. He is also the blood bank director at Bridgeport Hospital. He is past chair of the BeTheMatch Board of Directors and is a past-president of AABB. He is an associate editor of Transfusion and past-recipient of Emily Cooley, Morton Grove-Rasmussen and presidential awards from AABB.

Contributors

Preface

List of abbreviations

Section I: Transfusion medicine from ancient times to the current pandemic

Chapter 1. Transfusion in the new millennium – Ennio C. Rossi and Toby L. Simon

Chapter 2. Disaster and the blood community (including COVID-19)-Ruth Sylvester and Louis M. Katz

Chapter 3. Responding to the Regulatory Challenges during Emergencies and Epidemics- Peter Mark                                                     
Section II: Blood donation

Chapter 4 Recruitment and screening of donors and the collection of blood—Susan Rossmann, Mary Townsend and Toby L. Simon

Chapter 5 Blood donor testing—Jed B. Gorlin and Nancy Van Buren

Chapter 6 Acute adverse reactions after blood donation– Anne F. Eder

Chapter 7 Chronic effects of blood and plasma donation—Bryan Spencer and T. Simon

Chapter 8 Global perspective: ensuring blood and blood product safety and availability through regulation and certification-Eva D. Quinley

Section III: Blood groups and pretransfusion testing

Chapter 9 Carbohydrate blood groups- Laura Cooling

Chapter 10 Rh and LW blood group antigens- Connie M. Westhoff, Don L. Siegel, and Aline Floch

Chapter 11 Other protein blood groups- Jill Storry and Jennifer Ricci Hagman

Chapter 12 Molecular and routine compatibility testing–Connie Westhoff

Section IV: Blood components

Part A. Red cells

Chapter 13 Red blood cell production and kinetics—Mark J. Koury and Lionel Blanc

Chapter 14 Red cell metabolism, preservation and oxygen delivery—John Hess and Angelo D’Alessandro

Part B: Platelets

Chapter 15 Platelet production and kinetics- Christopher A. Tormey, Henry M. Rinder, and Thomas C. Binns

Chapter 16 Platelet immunology and alloimmunization- Cheryl L. Maier and Seema R. Patel and H. Clifford Sullivan

Chapter 17 Preparation, preservation, and storage of platelet concentrates- Moritz Stolla and Valery J. Li and Johnathan P. Mack  

Part C: White cells

Chapter 18 Neutrophil production and kinetics: neutropenia and neutrophilia- Lawrence Rice and Eric Salazar  

Chapter 19 Granulocyte collection and transfusion- Jeffrey McCullough, Corrinne Goldberg and Jenny Petkova

Part D: Plasma

Chapter 20 Composition of plasma – Peter Hellstern

Chapter 21 Plasma and cryoprecipitate for transfusion including SD plasma- Simon Stanworth and Toruma Apelseth

Chapter 22 The purification of plasma proteins for therapeutic use- Nathan Brinkman, Karl McCann, and Barry Gooch 

Chapter 23  Immunoglobulins Products- Melvin Berger

Section V: Apheresis

Chapter 24 Basic principles of apheresis and the collection of blood components by apheresis- Jeffrey L. Winters and Edwin A. Burgstaler

Chapter 25 Therapeutic apheresis: Plasma processing – Patricia A.R. Brunker and Monica B. Pagano

Chapter 26  Therapeutic phlebotomy and specialized hemapheresis- Patricia Brunker and Jeffey Bailey

Section VI: Blood transfusion

Chapter 27 Patient blood management- Darrell J. Triulzi and Jansen N. Seheult and

Mark H. Yazer and Jonathan H. Waters

Chapter 28 Clinical and technical aspects of blood administration – Edward S. Lee, Debra L. Mraz, and Edward L. Snyder

Chapter 29 Anemia and RBC transfusion- Jeff Carson

Chapter 30 Sickle cell disease, thalassemia, and hereditary hemolytic anemias-Ross M. Fasano, Emily Riehm Meier and Satheesh Chonat

Chapter 31 Autoimmune hemolytic anemias and paroxysmal nocturnal hemoglobinuria-Christopher A. Tormey and Alexa J. Siddon

Chapter 32 Hemolytic disease of the fetus and newborn- Megan Delaney, Wen Lun, Jennifer Webb

Chapter 33 Obstetric transfusion practice- Roback

Chapter 34 Transfusion in Infants and Children-Jeanne E. Hendrickson and Cassandra D. Josephson

Chapter 35 Thrombocytopenia and platelet transfusion-Michael F. Murphy, Lise J Estcourt and Simon J. Stanworth

Chapter 36 Immune mediated Thombocytopenia- Theodore Warkentin, Donald Arnold, Ishac Nazi, and James W. Smith

Chapter 37 Coagulation Concentrates for Inherited Bleeding Disorders—Robert F. Sidonio and Gary M. Woods

Chapter 38 Coagulation factor concentrates and pharmacologic therapies for acquired bleeding disorders- Ravi Sarode and Natalie Bavli

Chapter 39 Perioperative transfusion practice- James R. Stubbs, Allan Klompas, and Leanne Thalji

Chapter 40 Transfusion therapy in the care of trauma and burn patients- John R. Hess, Eileen M. Bulger, Benjamin Huebner, and Samuel Mandell

Chapter 41 Transfusion support for the oncology patient- Kristin M. Stendahl, Wade L. Schulz, Edward L. Snyder

Chapter 42 Pathogen reduction of blood components- Snyder and McCullough                  

Section VII: Adverse sequelae of transfusion

Chapter 43 Hemovigilance: weighing transfusion risks and benefits- Scott Kopesell

Chapter 44 Transfusion transmitted virus infections-Erhard Seifried

Chapter 45 Transfusion transmission of parasites and prions - Bryan Spencer and Paula Saa

Chapter 46 Bacterial Contamination of Blood Components- Evan M. Bloch, Richard J. Benjamin and Sandra Ramirez

Chapter 47 Hemolytic transfusion reactions- Celina Montemayor Garcia and Sandhya R. Panch

Chapter 48 Febrile, allergic, and nonimmune transfusion reactions- Emmanuel A. Fadeyi and Gregory J. Pomper

Chapter 49 Transfusion-related lung injury- Ulrich Sachs and Johnathan P. Wallis

Chapter 50 Transfusion-associated graft-versus-host disease- Eric A. Gehrie and Courtney E. Lawrence

Chapter 51 Transfusion-associated iron overload- Sujit Sheth

Section VIII: Cellular and tissue transplant technologies

Chapter 52 Hematopoetic growth factors and Cytokines-David Kuter

Chapter 53 Hematopoetic stems cells and transplantation- Garrett S. Booth

Chapter 54 HLA antigens, alleles, and antibodies—Harold Clifford Sullivan, Robert A. Bray, Howard M. Gebel and Scott M. Krummey

Chapter 55 Car-T cells and other cellular immunotherapies- Don Siegel and Andrew Fesnak

Chapter 56 Gene therapy applications to transfusion medicine-Diane S. Krause, Seena Tabibi, Emanuela M. Bruscia and Eric A. Gehrie

Chapter 57 Tissue engineering and regenerative medicine-Julie G. Allickson

Chapter 58 Human Tissue Allografts: Following the Path from Donor to Recipient - Matthew J. Kuehnert and Cassandra D. Josephson    

Index

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