Highly regarded by both students and instructors, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 5th Edition, provides a unique, integrated mechanism-based and systems-based approach to contemporary pharmacology and drug development. An easy-to-follow format helps both undergraduate and graduate students grasp challenging concepts quickly and efficiently. Each chapter presents a clinical vignette illustrating a therapeutic problem within a physiologic or biochemical system; followed by a discussion of the biochemistry, physiology, and pathophysiology of the system; and concluding with a presentation of the pharmacology of the drugs and drug classes that activate or inhibit the system by interacting with specific molecular and cellular targets.

• Chapters are integrated into sections that focus on organ systems and therapeutic areas of highest importance.
• Hundreds of clear, concise illustrations highlight new understanding of physiologic, pathophysiologic, and pharmacologic mechanisms, and dozens of popular and practical drug summary tables offer quick access to essential information.
• All chapters have been comprehensively updated, including recently discovered mechanisms and recently approved drugs.
• Content updates, new chapters, new figures, and new cases added to key areas such as endophenotypes as drug targets, immunotherapy, protein-based therapeutics, oligonucleotide-based therapies, and gene therapy and gene editing.
• Dr. David Golan’s pathophysiologic approach, pioneered at Harvard, mirrors critical thinking and is ideal for integrated, systems-based courses.