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Emphasizing pharmacogenomics and its influence on drug therapy, this book offers a comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the individual patients body. It covers new and emerging aspects of drug transporter pharmacogenomics, from the basic science, to transporter function, factors that influence transporters, impact on bioavailability and disposition, metabolism-transport interplay, pharmaceutical applications, and regulatory matters. The book has sufficient detail for non-specialists while also providing a practical, hands-on resource for researchers in the pharmaceutical industry, academic research, and government agencies.
TOSHIHISA ISHIKAWA, PhD, is Senior Scientist at RIKEN Yokohama Institute and Professor of Biochemistry, Molecular Biology, and Pharmacogenomics at Yokohama City University's Graduate School of Medicine. Previously, Dr. Ishikawa was the Director of the Department of Research Technology Development at Pfizer, Japan. A recipient of the Achievement Award from the International Life Sciences Institute (ILSI), Dr. Ishikawa is also the cofounder of the International Transporter Consortium (ITC).
RICHARD B. KIM, MD, FRCPC, is Professor and Chair of the Division of Clinical Pharmacology and Associate Chair for Research in the Department of Medicine at the University of Western Ontario. He is a Fellow of the American Association of Pharmaceutical Scientists and an elected member of the American Society for Clinical Investigation.
JÖRG KÖNIG, PhD, is Professor and Head of the Molecular Biology Laboratories in the Department of Clinical Pharmacology at the Friedrich-Alexander Universität Erlangen-Nürnberg.
Table of Contents
Chapter 1: Introduction to pharmacogenomics of drug transporters Marianne K DeGorter and Richard B Kim
Chapter 2: ADME Pharmacogenomics in Drug Development Liangfu Chen and Joseph W. Polli
Chapter 3: Regulatory Perspective on Pharmacogenomics of Drug Metabolizing Enzymes and Transporters Lei Zhang, Gilbert J. Burckart, Shiew-Mei Huang and Lawrence J. Lesko
Chapter 4: The Pharmacogenomics of Membrane Transporters Project Sook Wah Yee, Deanna L. Kroetz and Kathleen M. Giacomini
Chapter 5: Emerging new technology of SNP typing Toshihisa Ishikawa and Yoshihide Hayashizaki
Chapters 6: OATP1A2, OAT1 and OAT3 Rommel G. Tirona
Chapter 7: OATP1B1, OATB1B3 and OATP2B1 Jörg König and Martin Fromm
Chapter 8: OCT (SLC22A) and OCTN Families Sophie L. Stocker, Kathleen M. Giacomini, Arian Emami-Riedmaier and A. Matthias Schwab
Chapter 9: MATE (SLC47) Family
Atsushi Yonezawa andKen-ichi Inui
Chapter 10: PEPT (SLC15A) Family Tomoko Sugiura, Saki Umeda, Akira Tsuji and Yukio Kato
Chapter 11: Nucleoside Transporters (SLC28 and SLC29) Family Míriam Molina-Arcas and Marçal Pastor-Anglada