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Immunology: A Short Course, Sixth Edition introduces all the critical topics of modern immunology in clear and succinct yet comprehensive fashion. The authors offer a uniquely balanced coverage of classical and contemporary approaches, basic and clinical aspects. As with the previous editions, the strength of the text is in a complete review of modern immunology without burdening the reader with excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics illustrated by uniformly drawn, full-color illustrations, many brand new to this edition. The sixth edition of this successful textbook newly covers: Toll-like receptors, their ligands and intracellular activation pathways The key role of activation induced cytidine deaminase (AID) in somatic hypermutation and class switch recombination. The autoimmune regulator (AIRE) gene in self-tolerance and autoimmunity T and B cell activation and the immunological synapse, as well as characterization and mechanisms of action of T regulatory cellsPraise for the previous edition:"This book is clearly a precious resource for undergraduate, graduate and medical students alike... For those who need an introduction to the fascinating world of immunology, this book should most certainly spark the interest." ANNALS OF BIOMEDICAL ENGINEERING"... an excellent beginner's guide... the authors have done a terrific job of providing an overview of the field." YALE JOURNAL OF BIOLOGY AND MEDICINE
Dr. Richard Coico is Professor and Chairman of the Department of Microbiology and Immunology and Dean at the City University of New York Medical School. He directs CUNY Microbiology and Immunology courses and also participates directly in the teaching of immunology to graduate students.
Dr. Sunshine is a Senior Scientist at the Health Effects Institute in Cambridge, Massachusetts. He is also a lecturer in the Department of Pathology at Tufts University School of Medicine.
Table of Contents
About the Authors
Preface and Acknowledgments
Overview of the Immune System
Elements of Innate and Acquired Immunity
Immunogens and Antigens
Antibody Structure and Function
Antigen-Antibody Interactions, Immune Assays, and Experimental Systems
The Genetic Basis of Antibody Structure
Biology of the B Lymphocyte
The Role of the Major Histocompatibility Complex in the Immune Response
Biology of the T Lymphocyte
Activation and Function of T and B Cells
Tolerance and Autoimmunity
Hypersensitivity: Type I
Hypersensitivity: Types II and III
Hypersensitivity: Type IV
Immunodeficiency Disorders and Neoplasias of the Lymphoid System
Resistance and Immunization to Infectious Diseases
Table of Contents provided by Publisher. All Rights Reserved.