On the same day Greek American marine biologist Amelia Drakos receives word that funding for her beloved Seahorse Laboratory has been cut, she discovers that her deceased father had lived a secret life.

With foreclosure and unemployment looming, as well as the fallout from a brief, confusing love affair, Amelia reluctantly becomes curator for Minnesota's Mall of America Sea Life Aquarium. At the same time, a string of perplexing e-mails from someone with her late father's name, Ted Drakos, arrive. Ted claims that he has important information about an inherited property on Lake Superior. And that he is her older brother.

When Amelia and Bryce, a long-time friend, go to check out the property, they discover week-old, orphaned, husky/wolf-hybrid pups under the dilapidated porch. Amelia adopts the pups and takes them back with her to Minneapolis, where they introduce chaos into her already crazy life.

Amelia and Bryce soon find themselves embroiled in the midst of a very angry environmental debate regarding reinstatement of the wolf hunt in Wisconsin. Amelia wonders if she and her newfound brother can overcome the sins of their father and find peace.

In Fly by Night, Andrea Thalasinos shows that family secrets can jump-start a new way of looking at the world.