Although the connection between disagreement and skepticism has been a focus of analysis in recent discussions of the epistemic significance of disagreement, it has arguably received less attention than it deserves. This collection fills in the gap by exploring the skeptical implications of disagreement not only in epistemology, but also in ethics, philosophy of religion, and philosophical inquiry itself, and by looking at the Pyrrhonian skeptic's treatment of disagreement from the perspective of contemporary analytic epistemology. It is thus intended as a key contribution to a fertile new area of study.