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Clinical Immunology

by: Sheehan, Catherine

Clinical Immunology

by: Sheehan, Catherine

ISBN 13:
9780397553136
ISBN 10:
0397553137
Edition: 2nd
Format: Hardcover
Copyright: 06/01/1997
Publisher: Lippincott Williams & Wilkins

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Summary

Univ. Of Massachusetts, North Dartmouth. A Brandon/Hill Allied Health selection. Introductory textbook for clinical laboratory science students. Includes chapter outlines and review questions. 12 U.S. contributors. Color plates. DNLM: Immune System.

Part I Immunobiology

(88)

1 Introduction to Immunology

(4)

Catherine Sheehan

What Is Immunology?

(2)

Antigens and Antibodies

(1)

Scope of Immunology

(1)

2 Cells and Tissues of the Immune System

(12)

Dorothy J. Fike

Cells of the Immune System

(7)

Organs and Tissues of the Immune System

(5)

3 Mechanisms of the Specific Immune Response

(14)

Anne E. Huot

Overview

(1)

Antigen Recognition

(1)

Effector Mechanisms

(7)

Regulatory Mechanisms

(5)

4 Mechanisms of the Nonspecific Immune Response

(22)

Karen James

Cellular Mechanisms of the Nonspecific Immune Response

(5)

Humoral Mechanisms of the Nonspecific Immune Response

(17)

5 Major Histocompatibility Complex

(10)

Catherine Sheehan

MHC Products

(3)

HLA Detection

(1)

Inheritance of HLA

(1)

Clinical Importance of HLA Typing

(1)

Summary

(4)

6 Hypersensitivity

(12)

Anne E. Huot

Catherine Sheehan

Type I Hypersensitivity

(6)

Type II Hypersensitivity

(1)

Type III Hypersensitivity

(2)

Type IV Hypersensitivity

(3)

7 Tumor Immunology

(12)

Karen James

Immune Responsiveness to Tumors

(4)

Tumor Markers

(3)

Therapeutic Approaches to Cancer

(4)

Part II Immunologic Techniques

(110)

8 Immunoglobulin Structure and Function

(12)

Dorothy J. Fike

General Structure of the Antibody Molecule

(4)

Immunoglobulin Classes

(4)

Monoclonal Antibodies

(1)

Quantitation of Immunoglobulins

100

(3)

9 Nature of Antigens

103

(6)

Dorothy J. Fike

Immunogens and Antigens

103

(1)

Factors Affecting Immunogenicity

104

(1)

Haptens

105

(1)

Adjuvants

106

(3)

10 An Overview of Antigen-Antibody Interaction and Its Detection

109

(8)

Catherine Sheehan

The Basis of Antibody Structure

109

(2)

Forces Binding Antigen to Antibody

111

(1)

Elution

112

(1)

Antibody Affinity

112

(1)

Avidity

113

(1)

Specificity and Crossreactivity

113

(1)

Heterophile Antibodies

113

(2)

Assays Involving Antigen-Antibody Interactions

115

(1)

Conclusion

115

(2)

11 Precipitation

117

(10)

Dorothy J. Fike

Introduction

117

(1)

Types of Precipitation Reactions

118

(6)

Applications

124

(3)

12 Agglutination

127

(10)

Dorothy J. Fike

General Considerations

127

(1)

Phases of Agglutination

127

(2)

Classification of Agglutination Reactions

129

(2)

Additional Reagents Used in Agglutination Procedures

131

(6)

13 Assays Involving Complement

137

(8)

Dorothy J. Fike

Evaluation of Complement

137

(2)

Complement Components in Disease

139

(1)

Complement Fixation

140

(2)

Conclusion

142

(3)

14 Labeled Immunoassays

145

(16)

Catherine Sheehan

General Considerations

145

(1)

Classification of Immunoassays

146

(6)

Examples of Immunoassays

152

(4)

Interferences and Sources of Error

156

(1)

Applications

156

(5)

15 Immunofluorescence

161

(10)

Catherine Sheehan

Fluorescence

162

(1)

Methods

162

(1)

Fluorochromes

163

(1)

Fluorescence Microscopy

164

(2)

Standardization

166

(1)

Applications

167

(4)

16 Nephelometry

171

(8)

Alice K. Chen

Principles of Nephelometry

171

(2)

Methods

173

(1)

Instrumentation

174

(1)

Limitations of Light-Scattering Methods

175

(1)

Applications

176

(1)

Conclusions

177

(2)

17 Cellular Assays

179

(12)

Denise R. Zito

Lymphocyte Subset Enumeration

180

(1)

Flow Cytometry

180

(3)

T-Cell Subset Analysis

183

(1)

B-Cell Analysis

183

(1)

Lymphocyte Phenotyping in HIV Infection

184

(1)

Enumeration of Other Cells

184

(1)

Cell Separation and Viability Verification Techniques

184

(1)

Assays to Assess Cell Function

185

(4)

Summary

189

(2)

18 Nucleic Acid Probes and Blotting Techniques

191

(8)

William C. Wagener

Background

191

(1)

Principles

191

(4)

Clinical Applications

195

(4)

Part III Clinical Immunology

199

(152)

A. Infectious Disease Serology

199

(78)

19 Overview of Infectious Disease and Serology

201

(6)

Rosemarie Rumanek Romesburg

Natural Course of Infectious Disease

201

(1)

Serologic Support of Diagnosis

202

(1)

Viral Infections

203

(1)

Role of Interferon

204

(1)

Treatment of Viral Infections

204

(3)

20 Streptococcal Infection and Serology

207

(6)

Ann C. Albers

Organism

207

(1)

Poststreptococcal Sequelae

208

(1)

Laboratory Assays

209

(4)

21 Syphilis

213

(10)

Ann Marie McNamara

Syphilis

213

(3)

Direction Detection

216

(1)

Serologic Diagnosis

216

(4)

Summary

220

(3)

22 Borrelia burgdorferi Infection and Serology

223

(6)

Rosemarie Rumanek Romesburg

Organism

223

(1)

Lyme Disease

224

(1)

Diagnosis

225

(1)

Treatment

226

(1)

Prevention and Control

226

(3)

23 Rubella Virus Infection and Serology

229

(10)

Rosemarie Rumanek Romesburg

Virus

229

(1)

Diseases

230

(1)

Laboratory Testing

231

(1)

Clinical Indications

231

(1)

Hemagglutination Inhibition Test

232

(1)

Passive Hemagglutination

233

(1)

Solid Phase Immunoassays

234

(1)

Sucrose Density Gradient Ultracentrifugation

234

(1)

Rubella Vaccination

234

(5)

24 Epstein-Barr Virus Infection and Serology

239

(8)

Dorothy J. Fike

Epstein-Barr Virus

239

(1)

Diseases

240

(1)

Laboratory Tests

241

(4)

Other Changes

245

(2)

25 Viral Hepatitis

247

(10)

Ann Marie McNamara

Hepatitis Testing

247

(2)

Hepatitis A

249

(1)

Hepatitis B

250

(3)

Hepatitis C

253

(1)

Delta Hepatitis

253

(1)

Hepatitis E

254

(1)

Non--A-E Hepatitis

254

(1)

Summary

254

(3)

26 Human Immunodeficiency Virus Infection and Serology

257

(14)

Ann Marie McNamara

Human Immunodeficiency Virus

257

(3)

Effect of HIV on the Immune Response

260

(1)

Clinical Features

261

(2)

Laboratory Diagnosis

263

(4)

Prevention of HIV Infection in Health Care Workers

267

(1)

Summary

268

(3)

27 Serology of Miscellaneous Infectious Diseases

271

(6)

Denise R. Zito

Rickettsia

272

(1)

Mycoplasma

272

(1)

Legionella

273

(1)

Fungi

273

(1)

Toxoplasma

274

(1)

Viruses

274

(1)

Summary

275

(2)

B. Autoimmune Disease

277

(28)

28 Immunologic Tolerance

277

(6)

Catherine Sheehan

Introduction

277

(1)

Central Tolerance

277

(2)

Peripheral Tolerance

279

(1)

Immunoregulation

279

(1)

Factors Affecting Tolerance

279

(1)

Disruption of Tolerance

280

(1)

Conclusions

280

(3)

29 Non--Organ-Specific Autoimmune Disease

283

(14)

Dorothy J. Fike

Autoimmunity

283

(1)

Theories to Explain Harmful Autoimmune Reactions

284

(1)

Serological Findings Common to Non--Organ-Specific Autoimmune Diseases

285

(6)

Non--Organ-Specific Autoimmune Diseases

291

(6)

30 Organ-Specific Autoimmune Disease

297

(8)

Dorothy J. Fike

Organ versus Non-Organ Specificity

297

(1)

Organ-Specific Autoimmune Diseases

298

(5)

Conclusion

303

(2)

C. Immune Deficiencies

305

(12)

31 Immune Deficiency

305

(12)

Therese B. Datiles

Richard L. Humphrey

Primary Immune Deficiencies

307

(6)

Secondary Immune Deficiencies

313

(4)

D. Proliferative Disease

317

(26)

32 Hypergammaglobulinemia

317

(14)

Therese B. Datiles

Richard L. Humphrey

Introduction

317

(1)

Cellular Basis

318

(1)

Laboratory Evaluation

319

(2)

Clinical Correlation

321

(10)

33 Lymphocytic Leukemia and Lymphoma

331

(12)

J. Patrick Reed

Introduction

331

(1)

Lymphocyte Markers and Cell Identification

332

(1)

Lymphoma

333

(3)

Leukemia

336

(7)

E. Transplantation

343

(8)

34 Transplantation Immunology

343

(8)

Catherine Sheehan

Types of Grafts

343

(1)

Graft Acceptance and Rejection

344

(1)

Clinical Manifestations

345

(1)

Tissue Typing

346

(1)

Immunosuppression

346

(1)

Transplantation

347

(1)

Complications of Transplantation

348

(3)

Answers to Review Questions and Case Study Discussions

351

(8)

Glossary

359

(16)

Index

375

Amazon no longer offers textbook rentals. We do!

Clinical Immunology

Clinical Immunology

9780397553136

0397553137

Summary

Table of Contents

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