Endocrinology
by: Hadley, Mac E.
Endocrinology
by: Hadley, Mac E.
- ISBN 13:
9780130803566
- ISBN 10:
0130803561
- Edition: 5th
- Format: Hardcover
- Copyright: 01/01/2000
- Publisher: Benjamin Cummings
- Newer Edition
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Summary
Appropriate for one-semester junior-graduate level courses in Endocrinology, Endocrine Physiology, as well as courses in medicine, dentistry, pharmacology, nutrition, nursing and other related medical or animal sciences where endocrinology is the focus. Hadley provides comprehensive coverage of endocrinology, centralizing on the critical roles of chemical messengers and hormoneswhether they are of endocrine or neural originin the control of physiological processes. This up-to-date Fifth Edition depicts, through demonstration, the entire human endocrine system in examples designed specifically for premedical and related professional courses.
Table of Contents
Read morePreface | xix | ||||
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Answers to Review Exercises | 545 | (22) | |||
Bibliography | 567 | (4) | |||
Index | 571 |
Supplemental Materials
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Excerpts
Read morePrefaceThe central theme of this text is the role of chemical messengers, or hormones, whether they are of endocrine or neural origin, in the control of physiological processes. Although endocrine physiology has been separated from neurophysiology in the past, it is now amply documented that hormones may originate from either endocrine or neural tissue. Thus has emerged the field of neuroendocrinology. Several eminent endocrinologists have been awarded Nobel Prizes in Physiology/Medicine for their monumental efforts leading to the discovery and elucidation of the chemical structure of several brain neuropeptides (neurohormones); this clearly emphasizes the importance of the concept of neuroendocrine physiology. It is now also realized that the so-called "classical" hormones are produced in many sites throughout the body and may be released directly into the blood, into neuronal synapses, or into the immediate intercellular space to affect adjacent cellular activity. This more inclusive definition of "hormone", therefore, has been employed, as suggested by Nobel laureate Roger Guillemin. The important point emphasized in this definition is that it is both the method of delivery as well as the source of the hormone that is of greatest physiological significance.In Introduction to Endocrinology, a short chronology of endocrine research is presented. The concept of homeostasis is then discussed with special reference given to the roles of chemical messengers in the control of homeostatic systems. The reader is then provided with a general description of The Vertebrate Endocrine System, wherein an initial working vocabulary is established. Included here is a discussion of the general classes of chemical messengers and other cellular regulators (steroid and peptide hormones, neurohormones, chalones, growth factors, eicosanoids, pheromones); the cellular synthesis of chemical messengers and their secretion, delivery, and metabolism; and a general overview of the physiological role of hormones. In consideration of the various methodologies used in present-day endocrine research, it was considered necessary to add a chapter on Endocrine Methodologies early in the text. Classical surgical and histological techniques are discussed, as are more recent methods including radioimmunoassay, radioreceptor assay, radioisotope enzyme assay, autoradiography, and recombinant-DNA methodologies. It was also considered important to provide, early in the book, a discussion of General Mechanisms of Hormone Action, because these concepts are a necessary component of each of the following chapters. Included within this chapter is a discussion of cellular receptors, cyclic nucleotides as second messengers, prostaglandins (and prostacyclins, thromboxanes, and leukotrienes), stimulus-response coupling, calmodulin (a cellular calcium receptor), and phosphorylated proteins as physiological effectors.The source, synthesis, chemistry, and general role of the Pituitary Hormones in the control of endocrine physiology are discussed next, because the pituitary gland is a major source of hormones regulating many other endocrine glands. More specific details of the roles and actions of these hormones are provided in subsequent chapters. Because the secretion of each of the pituitary hormones is controlled by hypophysiotropic hormones of hypothalamic origin, a chapter on the role of The Endocrine Hypothalamus is provided. The evidence supporting the neurovascular hypothesis is emphasized.Chapter 7, Neurohypophysial Hormones, provides a complete coverage of the source, synthesis, chemistry, secretion, metabolism, biological actions, and mechanisms of action of the posterior pituitary hormones, oxytocin and vasopressin. The evolution of hormone structure is emphasized under the comparative endocrinology of neurohypophysial hormones. Chapter 8, The Melanotropic Hormones, emphasizes the recent discovery that pro-opiomelanocortin is the precursor prote
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