In a forgotten corner of western Kentucky lies a haunted forest referred to locally as "The Deadening," where vampire cults roam wild and time is immaterial. Our protagonist and his accomplice—the one and only, Carver Canute—set out down the Old Spur Line in search of the legendary Kudzu House, where an old couple is purported to have been swallowed whole by a hungry vine. Their quest leads them face to face with albino panthers, Great Dane-riding girls, protective property owners, and just about every American folk-demon ever, while forcing the protagonist to finally take stock of his relationship with his father and the man's mysterious disappearance.

The Vine That Ate the South is a mesmerizing fantasia where Wilkes ambitiously grapples with the contradictions of the contemporary American South while subversively considering how well we know our own family and friends.