A text based on the author's Masters level course on statistics applied to bioinformatics aimed at graduate students from statistics, bioinformatics and biology. Filling a gap in the current literature, the text includes a rigorous and extensive background in biostatistics, along with detailed explanation of the key biological questions before focusing on the statistical analysis. Including exercises, numerous illustrations, extensive end of chapter summaries and examples of programming in R (a freely availabe statistical package), this is an ideal study text.