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| Preface | p. ix |
| Acknowledgements | p. xi |
| Contributing authors | p. xiii |
| Introduction | p. 1 |
| The origins of the SCAM project | p. 1 |
| The scope of modelling in the modern world | p. 2 |
| The different professions and traditions engaged in modelling | p. 3 |
| Different types of models | p. 3 |
| Different purposes for modelling | p. 5 |
| The p... MORE | p. 6 |
| Overview of the chapters | p. 6 |
| References | p. 8 |
| Statistical model selection | p. 11 |
| Introduction | p. 11 |
| Explanation or prediction? | p. 12 |
| Levels of uncertainty | p. 12 |
| Bias-variance trade-off | p. 13 |
| Statistical models | p. 15 |
| Within-model inference | p. 16 |
| Model comparison | p. 18 |
| Bayesian model comparison | p. 18 |
| Model uncertainty | p. 19 |
| Laplace approximation | p. 20 |
| Penalized likelihood | p. 20 |
| Bayesian information criterion | p. 21 |
| The Akaike information criterion | p. 21 |
| Inconsistency of AIC | p. 23 |
| Significance testing | p. 23 |
| Many variables | p. 27 |
| Data-driven approaches | p. 28 |
| Cross-validation | p. 29 |
| Prequential analysis | p. 29 |
| Model selection or model averaging? | p. 30 |
| References | p. 31 |
| Modelling in drug development | p. 35 |
| Introduction | p. 35 |
| The nature of drug development and scope for statistical modelling | p. 36 |
| Simplicity versus complexity in phase III trials | p. 36 |
| The nature of phase III trials | p. 36 |
| The case for simplicity in analysing phase III trials | p. 37 |
| The case for complexity in modelling clinical trials | p. 38 |
| Some technical issues | p. 39 |
| The effect of covariate adjustment in linear models | p. 40 |
| The effect of covariate adjustment in non-linear models | p. 42 |
| Random effects in multi-centre trials | p. 44 |
| Subgroups and interactions | p. 45 |
| Bayesian approaches | p. 46 |
| Conclusion | p. 46 |
| Appendix: The effect of covariate adjustment on the variance multiplier in least squares | p. 47 |
| References | p. 48 |
| Modelling with deterministic computer models | p. 51 |
| Introduction | p. 51 |
| Metamodels and emulators for computationally expensive simulators | p. 52 |
| Gaussian processes emulators | p. 53 |
| Multivariate outputs | p. 56 |
| Uncertainty analysis | p. 57 |
| Sensitivity analysis | p. 58 |
| Variance-based sensitivity analysis | p. 58 |
| Value of information | p. 61 |
| Calibration and discrepancy | p. 63 |
| Discussion | p. 64 |
| References | p. 65 |
| Modelling future climates | p. 69 |
| Introduction | p. 69 |
| What is the risk from climate change? | p. 70 |
| Climate models | p. 70 |
| An anatomy of uncertainty | p. 72 |
| Aleatoric uncertainty | p. 72 |
| Epistemic uncertainty | p. 73 |
| Simplicity and complexity | p. 75 |
| An example: The collapse of the thermohaline circulation | p. 77 |
| Conclusions | p. 79 |
| References | p. 79 |
| Modelling climate change impacts for adaptation assessments | p. 83 |
| Introduction | p. 83 |
| Climate impact assessment | p. 84 |
| Modelling climate change impacts: From world development paths to localized impacts | p. 87 |
| Greenhouse gas emissions | p. 87 |
| Climate models | p. 90 |
| Downscaling | p. 93 |
| Regional/local climate change impacts | p. 94 |
| Discussion | p. 95 |
| Multiple routes of uncertainty assessment | p. 96 |
| What is the appropriate balance between simplicity and complexity? | p. 96 |
| References | p. 98 |
| Modelling in water distribution systems | p. 103 |
| Introduction | p. 103 |
| Water distribution system models | p. 104 |
| Water distribution systems | p. 104 |
| WDS hydraulic models | p. 104 |
| Uncertainty in WDS hydraulic modelling | p. 107 |
| Calibration of WDS hydraulic models | p. 108 |
| Calibration problem | p. 108 |
| Existing approaches | p. 109 |
| Case study | p. 113 |
| Sampling design for calibration | p. 116 |
| Sampling design problem | p. 116 |
| Existing approaches | p. 116 |
| Case study | p. 120 |
| Summary and conclusions | p. 120 |
| References | p. 122 |
| Modelling for flood risk management | p. 125 |
| Introduction | p. 125 |
| Flood risk management | p. 126 |
| Long-term change | p. 130 |
| Uncertainty | p. 131 |
| Multi-purpose management | p. 131 |
| Modelling for flood risk management | p. 132 |
| Source | p. 132 |
| Pathway | p. 132 |
| Receptors | p. 135 |
| An example of a system model: Towyn | p. 135 |
| Model choice | p. 137 |
| Conclusions | p. 143 |
| References | p. 144 |
| Uncertainty quantification and oil reservoir modelling | p. 147 |
| Introduction | p. 147 |
| Bayesian framework | p. 148 |
| Solution errors | p. 149 |
| Quantifying uncertainty in prediction of oil recovery | p. 150 |
| Stochastic sampling algorithms | p. 151 |
| Computing uncertainties from multiple history matched models | p. 153 |
| Inverse problems and reservoir model history matching | p. 155 |
| Synthetic problems | p. 155 |
| Imperial college fault model | p. 157 |
| Comparison of algorithms on a real field example | p. 158 |
| Selecting appropriate detail in models | p. 162 |
| Adaptive multiscale estimation | p. 162 |
| Bayes factors | p. 165 |
| Application of solution error modelling | p. 167 |
| Summary | p. 170 |
| References | p. 171 |
| Modelling in radioactive waste disposal | p. 173 |
| Introduction | p. 173 |
| The radioactive waste problem | p. 174 |
| What is radioactive waste? | p. 174 |
| How much radioactive waste is there? | p. 175 |
| What are the options for long-term management of radioactive waste? | p. 175 |
| The treatment of uncertainty in radioactive waste disposal | p. 177 |
| Deep geological disposal | p. 177 |
| Repository performance assessment | p. 177 |
| Modelling | p. 179 |
| Model verification and validation | p. 180 |
| Strategies for dealing with uncertainty | p. 182 |
| Summary and conclusions | p. 184 |
| References | p. 184 |
| Issues for modellers | p. 187 |
| What are models and what are they useful for? | p. 187 |
| Appropriate levels of complexity | p. 189 |
| Uncertainty | p. 190 |
| Model inputs and parameter uncertainty | p. 190 |
| Model uncertainty | p. 191 |
| References | p. 192 |
| Glossary | p. 193 |
| Index | p. 201 |
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