Preface 6

Table and figure acknowledgements 7

About the companion website 9

Part 1 Normal human reproduction

1 The pituitary gland and gonadotropins 10

2 Steroid hormone biosynthesis 12

3 Steroid hormone mechanism of action and metabolism 14

4 Reproductive genetics 16

5 Gonadal development in the embryo 18

6 Phenotypic sex differentiation 20

7 Gross anatomy of the male reproductive tract 22

8 Microscopic anatomy of the male reproductive tract 24

9 Gross anatomy of the female reproductive tract 26

10 Microscopic anatomy of the female reproductive tract 28

11 Puberty in boys 30

12 Puberty in girls 32

13 Male reproductive physiology 34

14 The menstrual cycle 36

15 Human sexual response 38

16 Fertilization and the establishment of pregnancy 40

17 Placental structure and function 42

18 The protein hormones of pregnancy 44

19 The steroid hormones of pregnancy 46

20 Maternal adaptations to pregnancy: I 48

21 Maternal adaptations to pregnancy: II 50

22 Labor 52

23 The breast and lactation 54

24 Menopause 56

25 Contraception 58

Part 2 Human reproductive disorders

26 Abnormalities of male sexual differentiation and development 60

27 Abnormalities of female sexual differentiation and development 62

28 Precocious puberty 64

29 Delayed or absent puberty 66

30 Primary amenorrhea 68

31 Secondary amenorrhea 70

32 Hyperprolactinemia 72

33 Sexual dysfunction 74

34 Infertility 76

35 Multifetal pregnancy 78

36 Spontaneous pregnancy loss 80

37 Labor abnormalities 82

38 Pre-eclampsia 84

39 Benign and malignant diseases of the breast 86

40 Testicular tumors 88

41 Diseases of the prostate 90

42 Ovarian neoplasms 92

43 Endometrial cancer 94

44 Cervical cancer 96

45 Genetic imprinting and reproductive tract tumors 98

46 Sexually transmitted diseases of bacterial origin 100

47 Sexually transmitted diseases of viral origin 102

48 The special cases of syphilis and human immunodeficiency virus 104

Index 107

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