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Reparative Medicine : Growing Tissues and Organs

by: Sipe, Jean D.; Kelley, Christine A.; McNicol, Lore Anne

Reparative Medicine : Growing Tissues and Organs

by: Sipe, Jean D.; Kelley, Christine A.; McNicol, Lore Anne

ISBN 13:
9780801878282
ISBN 10:
0801878284
Edition: 1st
Format: Paperback
Copyright: 09/01/2003
Publisher: Johns Hopkins Univ Pr
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Summary

This volume covers topics that encompass the use of components of the body, such as genes, proteins, and cells, to either foster tissue regeneration and remodeling in vivo for the purpose of repairing, replacing, maintaining, or enhancing organ function, or to engineer functional tissues in vitro for implantation in vivo as a biological substitute for damaged or diseased tissues and organs. Table of Contents:Reparative Medicine: Growing Tissues and OrgansPart I. Cells for Repair: A. Cell Regeneration Part I. Cells for Repair: B. Genetic Approaches to Tissue Repair Part II. Bioscaffolds for Tissue Repair Part III. Molecular Signaling Part IV. Tissue Generation: A. Functional Considerations in the Design of Engineered Tissue Part IV. Tissue Generation: B. Bioreactors and BioprocessingPart IV. Tissue Generation: C. Vascular Assembly in Engineered and Natural TissuesPart IV. Tissue Generation: D. Storage and Translational Issues Part V. Engineered Tissues in the Host: A. In Vivo Remodeling Part V. Engineered Tissues in the Host: B. Immune Response to Engineered Tissues and Cell

Preface.

By JEAN D. SIPE, CHRISTINE A. KELLEY, AND LORE ANNE MCNICOL

xiii

Tissue Engineering and Reparative Medicine.

By JEAN D. SIPE

(9)

In Vitro Systems for Tissue Engineering.

By W.T. GODBEY AND A. ATALA

(17)

Part I. Cells for Repair

A. Cell Regeneration

The Use of Cells in Reparative Medicine.

By NANCY L. PARENTEAU AND JANET HARDIN YOUNG

(13)

Reversal of Established Autoimmune Diabetes by in Situ β-Cell Regeneration.

By DENISE L. FAUSTMAN

(1)

Pancreatic Islet Cell Replacement: Successes and Opportunities.

By SEUNG K. KIM

(3)

Building Animals from Stem Cells.

By RON MCKAY

(1)

Cells for Repair: Breakout Session Summary.

By DENISE L. FAUSTMAN, ROGER L. PEDERSEN, SEUNG K. KIM, IHOR R. LEMISCHKA, AND RONALD D. MCKAY

(3)

B. Genetic Approaches to Tissue Repair

Genetic Approaches to Craniofacial Tissue Repair.

By JEFFREY BONADIO AND MICHAEL L. CUNNINGHAM

(10)

Genetic Approaches to Tissue Repair.

By JEFFREY BONADIO

(3)

Gene Transfer in Tissue Regeneration and Reparative Medicine.

By SAVID L.C.WOO

(2)

Gene-Based Approaches to the Treatment of Hemophilia.

By KATHERINE HIGH

(2)

Genetic Approaches to the Repair of Connective Tissues.

By STEVEN C. GHIVIZZANI

(3)

Genetic Approaches to Tissue Repair.

By DAVID V. SCHAFFER

(3)

Genetic Approaches to Tissue Engineering: Breakout Session Summary.

By JEFFREY BONADIO, SAVIO L.C. WOO, KATHERINE HIGH, STEVEN C. GHIVIZZANI, AND DAVID SCHAFFER

(2)

Different Osteochondral Potential of Clonal Cell Lines Derived from Adult Human Trabecular Bone.

By ANNA M. OSYCZKA, ULRICH NÖTH, KEITH G. DANIELSON, AND ROCKY S. TURN

(5)

Therapeutic Potential of Implanted Tissue-Engineered Bioartificial Muscles Delivering Recombinant Proteins to the Sheep Heart.

By Y. LU, J. SHANSKY, M. DEL TATTO, P. FERLAND, S. MCGUIRE, J. MARSZALKOWSKI, M. MAISH, R. HOPKINS, X. WANG, P. KOSNIK, M. NACKMAN, A. LEE, B. CRESWICK, AND H. VANDENBURGH

(5)

Part II. Bioscaffolds for Tissue Repair

Emerging Design Principles in Biomaterials and Scaffolds for Tissue Engineering.

By LINDA G. GRIFFITH

(13)

Biomaterials and Scaffolds in Reparative Medicine.

By ELLIOT L. CHAIKOF, HOWARD MATTHEW, JOACHIM KOHN, ANTONIOS G. MIKOS, GLENN D. PRESTWICH, AND CHRISTOPHER M. YIP

(10)

Hybrid, Composite, and Complex Biomaterials.

By GLENN D. PRESTWICH AND HOWARD MATTHEW

106

(3)

Biomaterials in Reparative Medicine: Biorelevant Structure-Property Analysis.

By CHRISTOPHER YIP

109

(3)

Bioscaffolds for Tissue Repair: Breakout Session Summary.

By ELLIOT CHAIKOF, HOWARD MATTHEW, JOACHIM KOHN, GLENN D. PRESTWICH, ANTONIO MIKOS, AND CHRISTOPHER YIP

112

(2)

Manufacturing and Characterization of 3-D Hydroxyapatite Bone Tissue Engineering Scaffolds.

By T.-M.G. CHU, S.J. HOLLISTER, J.W. HALLORAN, S.E. FEINRERG, AND D.G. URTON

114

(4)

Biological Response of Chondrocytes to Hydrogels.

By J.H. ELISSEEFF, A. LEE, H.K. KLEINMAN, AND Y. YAMADA

118

(5)

Engineering a Biological Joint.

By J. GLOWACKI, K.E. YATES, S. WARDEN, F. ALLEMANN, G. PERETTI, D. STRONGIN, R. MACLEAN, AND D.ZALESKE

123

(3)

The Efficacy of Bone Marrow Stromal Cell-Seeded Knitted PLGA Fiber Scaffold for Achilles Tendon Repair.

By HONG WEI OUYANG, JAMES C.H. GOH, XIU MEI MO, SWEE HIN TEOH, AND ENG HIN LEE

126

(4)

Effects of Alginate Composition on the Growth and Overall Metabolic Activity of βTC3 Cells.

By CHERYL L. STABLER, ATHANASSIOS SAMBANIS, AND IOANNIS CONSTANTINIDIS

130

(4)

Polymer/Alginate Amalgam for Cartilage-Tissue Engineering.

By E.J. CATERSON, W.J. LI, L.J. NESTI, T. ALBERT, K. DANIELSON, AND R.S.TURN

134

(5)

Accelerated and Improved Osteointegration of Implants Biocoated with Bone Morphogenetic Protein 2 (BMP-2).

By HERBERT P. JENNISSEN

139

(4)

Part III. Molecular Signaling

Molecular Signaling in Bioengineered Tissue Microenvironments.

By DONALD P. BOTTARO, ANDREA LIEBMANN-VINSON, AND MUHAMMAD A. HEIDARAN

143

(11)

Cell-Cell and Cell-Extracellular Matrix Adhesion Receptors.

By CAROLINE DAMSKY

154

(2)

Convergence of Molecular Signaling and Tissue Engineering.

By MOHAMMAD A. HEIDARAN

156

(2)

The Role of Extracellular Matrix Heparan Sulfate Glycosaminoglycan in the Activation of Growth Factor Signaling Pathways.

By DONALD P. BOTTARO

158

(1)

Cell Adhesion Molecules Activate Signaling Networks That Influence Proliferation, Gene Expression, and Differentiation.

By KATHRYN L. CROSSIN

159

(2)

Molecular Signaling.

By PATRICIA DULY

161

(1)

Mechanical Signaling.

By DONALD INGBER

162

(2)

Molecular Signaling: Breakout Session Summary.

By CAROLINE DAMSKY, MOHAMMAD HEIDARAN, DONALD BOTTARO, KATHRYN CROSSIN, PATRICIA DULY, AND DONALD INGBER

164

(4)

The Provant® Wound Closure System Induces Activation of p44/42 MAP Kinase in Normal Cultured Human Fibroblasts.

By TERRI L. GILBERT, NICOLE GRIFFIN, JOHN MOFFETT, MARY C. RITZ, AND FRANK R. GEORGE

168

(4)

p38 MAP Kinase Regulation of AP-2 Binding in TGF-β1-Stimulated Chondrogenesis of Human Trabecular Bone-Derived Cells.

By R. TULI, M.R. SEGHATOLESLAMI, S. TULI, M.S. HOWARD, K.G. DANIELSON, AND R.S.TURN

172

(6)

TGF-β1-Stimulated Osteoblasts Require Intracellular Calcium Signaling for Enhanced α5 Integrin Expression.

By LEON J. NESTI, E.J. CATERSON, MARK WANG, RICHARD CHANG, FELIX CHAPOVSKY, JAN B. HOEK, AND ROCKY S. TURN

178

(5)

Part IV. Tissue Generation

A. Functional Considerations in the Design of Engineered Tissue

Tissue Engineering: Functional Assessment and Clinical Outcome.

By STEVEN A. GOLDSTEIN

183

(10)

Functional Tissue Engineering: The Role of Biomechanics in Reparative Medicine.

By FARSHID GUILAK

193

(3)

Fluorescence Imaging and Engineered Biosensors: Functional and Activity Based Sensing Using High Content Screening.

By RAVI KAPUR

196

(2)

Functional Considerations in Tissue-Engineering Whole Organs.

By MICHAEL V. SEFTON

198

(3)

Functional Assessment and Tissue Design of Skeletal Muscle.

By HERMAN H. VANDENBURGH

201

(2)

Functional Assessment of Tissues with Magnetic Resonance Imaging.

By ALAN P. KORETSKY

203

(3)

Determination of Responsiveness in Biological Systems Is Dependent on Highly Sensitive Quantitative Measures.

By REGIS J. O' KEEFE

206

(1)

Functional Assessment of Engineered Tissues and Elements of Tissue Design: Breakout Session Summary.

By FARSHID GUILAK, RAVI KAPUR, MICHAEL V. SEFTON, HERMAN H. VANDENBURGH, ALAN P. KORETSKY, ANDRES KRIETE, AND REGIS J. O'KEEFE

207

(3)

B. Bioreactors and Bioprocessing

Bioreactors and Bioprocessing for Tissue Engineering.

By ANTHONY RATCLIFFE AND LAURA E. NIKLASON

210

(6)

Tissue Engineering as a Subdivision of Bioprocess Engineering: Reparative Tissue Engineering as a Subspecialty of Tissue Engineering.

By KYUNG A. KANG

216

(4)

Bioreactors and Bioprocessing: Breakout Session Summary.

By LAURA E. NIKLASON, ANTHONY RATCLIFFE, KELVIN BROCKBANK, DUANE F. BRULEY, AND KYUNG A. KANG

220

(3)

C. Vascular Assembly in Engineered and Natural Tissues

Vascular Assembly in Natural and Engineered Tissues.

By KAREN K. HIRSCHI, THOMAS C. SKALAK, SHAYN M. PEIRCE, AND CHARLES D. LITTLE

223

(20)

In Vivo and in Silico Approaches for Analysis and Design of Multisignal, Multicomponent Assembly Processes in Vascular Systems.

By THOMAS C. SKALAK

243

(3)

Vascular Assembly in Engineered and Natural Tissues.

By LARRY V MCINTIRE

246

(3)

Angiogenesis: Initiation and Maintenance.

By MARK J. POST

249

(2)

The Tissue-Engineered Small-Diameter Artery.

By ROBERT T. TRANQUILLO

251

(4)

Vascular Assembly in Engineered and Natural Tissues: Breakout Session Summary.

By THOMAS C. SKALAK, CHARLES D. LITTLE, LARRY V. MCINTIRE, KAREN K. HIRSCHI, ROBERT T. TRANQUILLO, MARK POST, AND JOHN RANIERI

255

(3)

D. Storage and Translational Issues

Storage and Translational Issues in Reparative Medicine.

By MEHMET TONER AND JEFFERY KOCSIS

258

(5)

Neural Tissue Transplantation in Syringomyelia: Feasibility and Safety.

By DOUGLAS K. ANDERSON

263

(2)

Stabilization of Tissue-Engineered Products for Transportation and Extended Shelf-Life.

By KELVIN G.M. BROCKBANK

265

(3)

Engineering Human Tissues for in Vivo Applications.

By L. GERMAIN, F. GOULET, V. MOULIN, F. BERTHOD, AND F.A. AUGER

268

(3)

Cytoprotection by Stabilization of Cell Membranes.

By RAPHAEL C. LEE

271

(5)

Storage and Translational Issues in Reparative Medicine: Breakout Session Summary.

By JEFFREY D. KOCSIS, MEHMET TONER, DOUGLAS K. ANDERSON, KELVIN BROCKBANK, LUCIE GERMAIN, RAPHAEL C. LEE, AND BUDDY D. RATNER

276

(3)

Development of Artificial Blood Vessels: Seeding and Proliferation Characteristics of Endothelial and Smooth Muscle Cells on Biodegradable Membranes.

By PAUL I. MUSEY, SOBRASUA M. IBIM, AND NIRANJAN K. TALUKDER

279

(5)

In Vivo Remodeling of Surgically Constructed Vascular Anastomoses: Non-penetrating, Arcuate-Legged Clips versus Standard Suture.

By WOLFF M. KIRSCH, YONG HUA ZHU, ROBERT STECKEL, WALDO CONCEPCION, KERRY OBERG, LENNART ANTON, AND NORMAN PECKHAM

284

(4)

Simple Method for Increasing Cell-Attachment Ability of Biodegradable Polyester.

By IN KAP KO AND HIR00 IWATA

288

(4)

Engineering of Capillary Patterns in Muscle by a Nonmitogenic Copper-Ribonucleoprotein Angiomorphogen [Angiotropen CuRNP Ribokine].

By JOSEF H. WISSLER

292

(6)

Noninvasive Monitoring of a Retrievable Bioartificial Pancreas in Vivo.

By IOANNIS CONSTANTINIDIS, CHERYL L. STABLER, ROBERT LONG, JR., AND ATHANASSIOS SAMBANIS

298

(4)

Part V. Engineered Tissues in the Host

A. In Vivo Remodeling

In Vivo Studies to Evaluate Tissue Engineering Techniques.

By STEPHEN F. BADYLAK

302

(3)

Transition of Stem Cells to Therapeutically Functional Tissue-Specific Cells.

By MARKUS GROMPE

305

(2)

In Vivo Remodeling.

By ARNOLD I. CAPLAN

307

(2)

Regulated In Vivo Remodeling.

By HOWARD P. GREISLER

309

(3)

Consideration of Mechanical Factors.

By ROBERT E. GULDBERG

312

(3)

Is in Vivo Remodeling Necessary or Sufficient for Cellular Repair of the Heart?

By DORIS A.TAYLOR

315

(4)

In Vivo Remodeling: Breakout Session Summary.

By STEPHEN F. BADYLAK, MARKUS GROMDE, ARNOLD I. CAPLAN, HOWARD P. GREISLER, ROBERT E. GULDBERG, AND DORIS A. TAYLOR

319

(4)

B. Immune Response to Engineered Tissues and Cells

Immunological Concerns with Bioengineering Approaches.

By DAVID M. HARLAN, CHRISTOPHER L. KARP, POLLY MATZINGER, DAVID H. MUNN, RICHARD M, RANSOHOFF, AND DENNIS W. METZGER

323

(8)

Islet Cell Allotransplantation as a Model System for a Bioengineering Approach to Reparative Medicine: Immunological Concerns.

By DAVID M. HARLAN

331

(4)

Immune Responses to Tissue-Engineered Extracellular Matrix Used as a Bioscaffold.

By DENNIS W. METZGER

335

(2)

Immunological Barriers (Opportunities?) to the Use of Bioengineered Tissue: Taking Note of the Innate Immune System.

By CHRISTOPHER L. KARP, RICHARD WENSTRUP, AND DAVID L. BUTLER

337

(4)

An Innate Sense of Danger.

By POLLY MATZINGER

341

(2)

Tolerogenic Antigen-Presenting Cells.

By DAVID H. MUNN

343

(3)

Chemokines in Neurological Trauma Models.

By RICHARD M. RANSOHOFF

346

(4)

Immune Response to Engineered Tissues and Cells: Breakout Session Summary.

By DAVID M. HARLAN, DENNIS W. METZGER, CHRISTOPHER L. KARP, POLLY MATZINGER, DAVID H. MUNN, AND RICHARD M. RANSOHOFF

350

(2)

Tissue Engineering of Meniscal Cartilage Using Perfusion Culture.

By ANDRÉ A. NEVES, NICK MEDCALF, AND KEVIN M. BRINDLE

352

(4)

PROVANT® Wound-Closure System Accelerates Closure of Pressure Wounds in a Randomized, Double-Blind, Placebo-Controlled Trial.

By M.C. RITZ, R. GALLEGOS, M.B. CANHAM, M. ESKALAI, AND F.R. GEORGE

356

(4)

Interconnections between Inflammatory and Immune Responses in Tissue Engineering.

By JULIA E. BABENSEE, MELISSA M. STEIN, AND LEAH K. MOORE

360

(4)

Modulation of Interferon-Gamma Response by Dermal Fibroblast Extracellular Matrix.

By ANDREAS KERN, KANG LIU, AND JONATHAN MANSBRIDGE

364

(4)

Differential Inflammatory and Immunological Responses in Tissue Regeneration and Repair.

By RAYMOND E. SICARD

368

From Lab Bench to Market: Critical Issues in Tissue Engineering.

By GAIL K. NAUGHTON

372

(14)

Symposium Summary.

By ROBERT NEREM, HELENE SAGE, CHRISTINE A. KELLEY, AND LORE ANNE MCNICOL

386

(5)

Index of Contributors

391

Amazon no longer offers textbook rentals. We do!

Reparative Medicine : Growing Tissues and Organs

Reparative Medicine : Growing Tissues and Organs

9780801878282

0801878284

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