The Fourth Edition of this landmark work features nine new chapters and has been thoroughly revised and updated to reflect contemporary findings. It is the only text that covers every important aspect of radiation oncology--from basic cancer biology, radiation biology, and radiation therapy physics to state-of-the-art treatment regimens for all cancer sites and tumor types and discussions of results.Principles and Practice of Radiation Oncology is designed to provide a better understanding of the natural history of cancer, the physical methods of radiation application, the effects of irradiation on normal tissues, and the most judicious ways in which radiation therapy can be employed in the treatment of cancer patients. This encyclopedic text places greater emphasis on the use of radiation oncology in palliative and supportive care, in addition to therapy.Included in the new edition: chapters on molecular biology and physiology, technology assessment and cost benefit, combined chemotherapy and irradiation in head and neck cancer, breast: stage Tis, pancreas, leukemias (adult and childhood), retinoblastoma, unusual tumors in childhood, and endovascular brachytherapy. This edition also features expanded coverage of new 3-D techniques and IMRT and a greater emphasis on pediatric concerns.