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Principles and Practice of Clinical Virology

ISBN: 9780470517994 | 0470517999
Edition: 6th
Format: Hardcover
Publisher: Wiley
Pub. Date: 6/29/2009

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SummaryTable of Contents
Principles and Practice of Clinical Virology is the bible for all working in the field of clinical virology - from the trainee to the expert because there's always something new to learn! As before, the book provides a detailed account of the diagnosis and treatment of virus infections, with a stronger emphasis on clinical expertise and management. Each chapter deals with a single virus or group or viruses and is written by leading international experts in the field.What's new in this edition ... Showcases the wealth of new knowledge acquired o... MORE
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List of Contributors
Preface
Past, Present and Future of Clinical Virology: An Overview
Diagnostic Approaches
Introduction
Electron Microscopy
Histology/Cytology
Virus Isolation
Serology
Molecular Amplification Techniques
Recommended Diagnostic Investigations
Future Trends
Viral Transmission: Infection Acquired by the Blood-borne Route
Introduction
Prevention of Exposure through Infection Control
Prevention of Infection through Specific Pre- and Post-exposure Policies
Patient-to-patient Transmission
Patient-to-HCW Transmission
HCW-to-patient Transmission
Viral Transmission: Infection Acquired by All Other Routes (Respiratory, Eye-Nose-Mouth, Inoculation and Faeco-orally)
Introduction
Measles, Mumps and Rubella
Cytomegalovirus
Varicella Zoster Virus
Herpes Simplex Virus
Noroviruses
Rotavirus
Parvovirus B19
Respiratory Viruses
Emerging Virus Infections
Introduction
Factors Contributing to Emergence
Future Directions
Vaccinology
Introduction
Burden of Viral Diseases and their Reproductive Rates
The Immune System and its Role in Natural and Artificially-induced Immunity
Discovery of Protective Antigens in Pathogens
Presentation of Protective Antigens through Vaccines and Types of Vaccine
Research and Development on Vaccines and their Commercial Introduction
Social Marketing of Introduced Vaccines
Planning and Implementation of Vaccination Programmes
Surveillance of Disease Incidence and Adverse Events Before and After Implementation of Vaccination
Rectification of Publicized Falsehoods and Maintenance of Vaccination Coverage
Viral Vaccines on the Horizon and the Roadblocks to Future Vaccine Development
Closing Comments
Herpes Simplex Virus Type 1 and Type 2
Morphology
Replication
Epidemiology
Viral Diagnosis
Antiviral Chemotherapy
Clinical Features, Diagnosis and Management
Concluding Remarks
Varicella Zoster
Introduction
The Virus
Epidemiology
Clinical Features
Diagnosis of VZV Infection
Treatment
Prevention
Cytomegalovirus
Introduction
The Virus
Epidemiology
Routes of Infection
Pathogenesis
Clinical Features
Diagnosis
Management
Prevention
Treatment
Epstein-Barr Virus
Introduction
The Virus
Epidemiology
EBV-associated Diseases
EBV Infection in the Immunocompromized Host
Vaccine Development
Roseoloviruses: Human Herpesviruses 6A, 6B and 7
Introduction
Biology of the Viruses
Epidemiology and Pathogenesis
Disease Associations
Laboratory Diagnosis
Antiviral Therapy
Concluding Remarks
Kaposi's Sarcoma-associated Herpesvirus (Human Herpesvirus 8)
Introduction
Origin and Evolution of KSHV
Worldwide Distribution of KSHV in the General Population
Transmission
Clinical Manifestations
Pathogenesis
Diagnostic Assays
Antiviral Therapy
Hepatitis Viruses
Introduction
Hepatitis A
Hepatitis E
Hepatitis B
Hepatitis D
Hepatitis C
GB Virus C (GBV-C) and Torque Teno Virus (TTV)
Introduction
GB Virus C (GBV-C)
Torque Teno Virus (TTV)
Rotaviruses
Introduction
Rotavirus Structure, Genome and Gene-Protein Assignment
Classification
Replication
Pathogenesis
Immune Responses and Correlates of Protection
Illness, Diagnosis and Treatment
Epidemiology
Vaccine Development
Viruses other than Rotaviruses Associated with Acute Diarrhoeal Disease
Introduction
Enteric Adenoviruses
Noroviruses and Sapoviruses
Astroviruses
Gastrointestinal Viruses Not Regularly Associated with Acute Diarrhoeal Disease
Influenza
Introduction
Viral Variation
Virus Classification
Pathogenesis
Clinical Features
Diagnosis of Infection
Treatment and Prevention
Parainfluenza Viruses
Introduction
Taxonomy
Structure and Physical Properties
Receptors, Virus Entry and Host Range
Replication
Viral Transmission, Incubation and Shedding
Pathogenesis
Antigenicity and Immunity
Epidemiology
Clinical Features
Diagnosis
Prevention
Treatment
Respiratory Syncytial Virus
Introduction
The Virus
Epidemiology
Pathogenesis
Immunity
Clinical Features
Diagnosis
Management
Prevention
Adenoviruses
Introduction
Description and Characteristics of the Virus
Pathogenesis
Immune Response
Epidemiology
Clinical Features
Respiratory Infections
Ocular Infections
Gastrointestinal Infections
Haemorrhagic Cystitis
Adenoviruses Infections in Immunocompromized Patients
Other Clinical Manifestations
Diagnosis
Treatment
Prevention
Future Prospects
Rhinoviruses
Introduction
Taxonomy
Physical Properties
Incubation and Transmission
Host Range
Pathogenesis
Immunity
Epidemiology
Clinical Features
Diagnosis
Prevention and Treatment
Coronaviruses and Toroviruses
Introduction
The Viruses
Initiation of Infection and Pathogenesis
Epidemiology
Clinical Features
Diagnosis
RT-PCR
Prophylaxis: Active and Passive Immunization
Therapy
Acknowledgements
Measles Virus
Introduction
The Virus
Virus Morphology
Genome Structure
MV Protein Functions
The Replication Cycle
Biological Properties of the Measles Virus
Epidemiology and Relatedness of Different Virus Isolates
Clinical Manifestations
The Pathogenesis of Measles and its Complications
Diagnosis
Management
Prevention
Rubella
Historical Introduction
The Virus
Postnatally Acquired Infection
Congenitally Acquired Infection
Laboratory Techniques and Diagnosis
Prevention-Rubella Vaccination
Mumps
Introduction
The Virus
Pathogenesis
Clinical Picture
Laboratory Diagnosis
Epidemiology and Control
Enteroviruses
Introduction
The Viruses
Pathobiological and Clinical Aspects of Human Enteroviruses
Laboratory Diagnosis of Enterovirus Infections
Prevention and Treatment of Enterovirus Infections
Future Prospects
Poxviruses
Introduction
Virus Characteristics
Clinical Aspects of Orthopoxvirus Infections
Diagnosis
Medical Management
Other Poxviruses Infecting Humans
Diagnosis
Alphaviruses
Introduction
The Virus
Spectrum of Diseases Caused by Alphaviruses
Diagnosis of Alphavirus Infections
Management and Prevention
Alphaviruses Associated with Fevers and Polyarthritis
Alphaviruses Associated with Encephalitis
Other Alphaviruses
Flaviviruses
Introduction
Properties of the Virus
Yellow Fever
Other Members of the 'Unassigned'
Subgroup of Flaviviruses
Dengue
Zika
Japanese Encephalitis
St Louis Encephalitis
West Nile Virus
Murray Valley Encephalitis
Tick-borne Encephalitis
Omsk Haemorrhagic Fever
Kyasanur Forest Disease
Powassan Virus
Bunyaviridae
Introduction
The Virus
Laboratory Diagnosis
Genus Orthobunyavirus
Genus Phlebovirus
Genus Nairovirus
Genus Hantavirus
Bunyaviruses Unassigned to Genus
Arenaviruses
Introduction
Ultrastructure of Arenaviruses and Infected Cells
Chemical Composition
Replication
Diagnosis of Human Arenavirus Infections
Antigenic Relationships
Clinical and Pathological Aspects
Persistent Infection
Pathology of Arenavirus Infections: General Features
Other Arenavirus Infections
Summary
Filoviruses
Introduction
Epidemiology
Ecology
Transmission and Risk Factors
Clinical Spectrum
Laboratory Diagnosis
Patient Management
Past Infection and Persistence
Virology
Animal Models
Serological Studies
Pathogenesis and Immunology
Control
Perspective
Rabies and Other Lyssavirus Infections
Introduction
History
Classification
Virus Structure
Replication
Inactivation of Virus and Stability of Vaccine Antigen
Epizootiology and Epidemiology
Incidence of Human Rabies
Pathogenesis
Immunology
Routes of Infection
Clinical Features of Rabies in Animals
Clinical Features in Humans
Diagnosis
Management of Human Rabies
Pathology
Human Rabies Prophylaxis
Control of Animal Rabies
Papillomaviruses
Introduction
Classification
Physical and Chemical Properties
Serology
Viral Replication
Natural History of HPV Infections
Pathogenesis
Diagnosis
Treatment
Vaccination
The Human Polyomaviruses
Classification and Detection
Virion Structure and Composition
Virus Life Cycle
State of Human Polyomavirus Infection
Diagnostic Evaluation of Polyomavirus-associated Disease
Polyomavirus-specific Immune Response
Treatment of Polyomavirus-associated Diseases
Acknowledgements
Human Parvoviruses
Introduction
Human Parvovirus B19 (B19V)
Pathogenesis
Epidemiology
Clinical Features
Laboratory Diagnosis
Treatment and Prevention
Human Retroviruses
Introduction
Retrovirus Replication and Genomes
Taxonomy
Human and Zoonotic Retrovirus Infections
Retroviral Vectors
The Human T-lymphotropic Viruses
Introduction
History
The Virus
Diagnosis
Viral Variation
Epidemiology
Transmission
HTLV-associated Disease
Pathogenesis
Treatment
Prevention of Disease
HIV and HTLV Co-infection
Human Immunodeficiency Viruses
Introduction and Classification
Epidemiology
Replication
Host Genetic Determinants for HIV/AIDS
Viral Dynamics and Pathogenesis
Immune Responses
The Laboratory Diagnosis of HIV Infection
The Natural History of HIV Infection and Its Clinical Manifestations
Antiretroviral Therapy-A Historical Perspective
Monitoring of Antiretroviral Therapy and Resistance
Antiretroviral Drug Classes
Transmission of Drug Resistance
Prevention
Vaccines
Human Prion Diseases
Introduction to Prions and Historical Perspective
Structural Biology of Prions
Normal Cellular Function of PrP
Prion Strains
Neuronal Cell Death in Prion Disease
The 'Species Barrier'
Pathogenesis
Animal Prion Diseases
Aetiology and Epidemiology of Human Prion Disease
Clinical Features and Diagnosis
Molecular Diagnosis of Prion Disease
Pre-symptomatic and Antenatal Testing
Prevention and Public Health Management
Prognosis and Treatment
Concluding Remarks
Useful Websites
Index
Table of Contents provided by Publisher. All Rights Reserved.


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