RENT TEXTBOOKS

Methodologies for Metabolomics : Experimental Strategies and Techniques

by: Edited by Norbert Lutz , Jonathan Sweedler , Ron Wevers

ISBN: 9780521765909 | 0521765900

Edition: 1st
Format: Hardcover
Publisher: CAMBRIDGE UNIVERSITY PRESS
Pub. Date: 1/21/2013

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Summary Table of Contents

Methodologies for Metabolomics provides comprehensive descriptions of the newest strategies in metabolomic research. While a broad range of methodologies are presented, so too are applications including in vivo metabolomics in humans and animals, as well as in vitro analysis of tissue samples, cultured cells and biofluids.

Metabolomics, the global characterization of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and p... MOREathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways, and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites including nuclear magnetic resonance and mass spectrometry are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples, and diseases, ranging from in vivo metabolomics in humans and animals, to in vitro analysis of tissue samples, cultured cells and biofluids.

"While most of the focus in "omics" science over the past decade has been on sequencing the human genome [1] or annotating the human proteome [2], there is another equally important component of the human body that has, until recently, been largely overlooked: the human metabolome. The human metabolome can be thought of as the complete collection of small molecule metabolites found in our bodies. These small molecules include such chemical entities as peptides, amino acids, nucleic acids, carbohydrates, organic acids, vitamins, minerals, food additives, drugs and just about any other chemical (with a molecular weight 1500 Da) that can be used, ingested or synthesized by humans. Metabolites act as the bricks and mortar of our cells. They serve as the building blocks for all of our macromolecules including proteins, RNA, DNA, carbohydrates, membranes and all other biopolymers that give our cells their structure and integrity. Metabolites also act as the fuel for all cellular processes, the buffers to help tolerate environmental insults and the messengers for most intra- and intercellular events. Together with the genome and the proteome, the human metabolome essentially defines who and what we are"--Provided by publisher.

Exploring the human metabolome by NMR spectroscopy and mass spectroscopy
Methodological requirements for lipidomics research
Biological methods for metabolic research
Considerations in sample preparation, collection, and extraction approaches applied in microbial, plant, and mammalian metabolic profiling
MS-based methodologies for single-cell metabolite detection and identification
Direct metabolomics ... MORE
Bioinformatic approaches to process and annotate high-resolution mass spectrometry data
Approaches for natural product detection and structural elucidation using mass spectrometry with high mass accuracy
Metabolomics using ion mobility mass spectrometry
Metabolomics via biomedical mass spectrometry: from sampling to clinical applications
Analytical techniques in metabolomics integrating NMR and chromatography with
NMR of CSF: the neurometabolome
NMR analysis and genetic metabolic disease Udo
NMR methods for metabolomic investigation of amniotic fluid
Chemometric methods in NMR-based body fluid analysis
Lipid profiling in health and disease Christina
NMR-based saliva metabolomics Hanne
Reproducible sample preparation and spectrum acquisition techniques for metabolic profiling of human tissues by
MR spectroscopy in investigating the cancer metabolome in preclinical model systems
Metabolomic magnetic resonance spectroscopy of human tissue: a comparison of in vivo and HR-MAS ex vivo techniques
Phospholipidomics by P NMR spectroscopy of tissue extracts
C NMR for analysis of metabolic pathways
Hyperpolarized NMR spectroscopy - a new method for metabolomic research
Assignment strategies for NMR resonances in metabolomics research
Table of Contents provided by Publisher. All Rights Reserved.

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