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Jasper's Basic Mechanisms of the Epilepsies

by: Delgado-Escueta, Antonio V., M.D.; Wilson, Wilkie A., Ph.D.; Olsen, Richard W.; Porter, Roger J.

Jasper's Basic Mechanisms of the Epilepsies

by: Delgado-Escueta, Antonio V., M.D.; Wilson, Wilkie A., Ph.D.; Olsen, Richard W.; Porter, Roger J.

ISBN 13:
9780781714389
ISBN 10:
0781714389
Edition: 3rd
Format: Hardcover
Copyright: 07/01/1999
Publisher: Lippincott Williams & Wilkins
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Summary

Univ. of California, Los Angeles. Contains the latest research in neurology, pharmaceutical approaches, future investigation, and practical strategies for the diagnosis and treatment of idiopathic and symptomatic epilepsies. For clinicians and researchers. Halftone illustrations.

Contributing Authors

xvii

Foreword

xxix

Preface

xxxi

Acknowledgments

xxxiii

Section I: Introduction: The Provinces of the Epilepsies for Basic Research

New Waves of Research in the Epilepsies: Crossing into the Third Millennium

(56)

Antonio V. Delgado-Escueta

Wilkie A. Wilson

Richard W. Olsen

Roger J. Porter

Genetic Heterogeneity and Epidemiology of the Epilepsies

(22)

V. Elving Anderson

W. Allen Hauser

Stephen S. Rich

Section II: Neural Development, Genes, and the Epilepsies

Section II Introduction

(6)

Antonio V. Delgado-Escueta

Wilkie A. Wilson

Richard W. Olsen

Roger J. Porter

Homebox Genes in Development

(14)

Edoardo Boncinelli

Cortical Dysplasias, Genetics, and Epileptogenesis

(28)

Renzo Guerrini

Eva Andermann

Massimo Avoli

William B. Dobyns

The Relevance of Slight Migrational Disturbances (Microdysgenesis) to the Etiology of the Epilepsies

123

(10)

H.J. Meencke

G. Veith

The Role of Neural Activity in Synaptic Development and Its Implications for Adult Brain Function

133

(12)

Sandra M. Aamodt

Martha Constantine-Paton

Ontogeny of Channels, Transmitters, and Epileptogenesis

145

(16)

Arnold R. Kriegstein

David F. Ownes

Massimo Avoli

Age-Dependent Vulnerability to Seizures

161

(10)

E.F. Sperber

J. Veliskova

I.M. Germano

L.K. Friedman

S.L. Moshe

Nicotinic Receptor: A Prototype of Allosteric Ligand-Gated Ion Channels and Its Possible Implications in Epilepsy

171

(18)

Daniel Bertrand

Jean-Pierre Changeux

GABA is the Principal Fast Acting Excitatory Transmitter in the Neonatal Brain

189

(14)

Xavier Leinekugel

Ilgram Khalilov

Heather McLean

Olivier Caillard

Jean-Luc Gaiarsa

Yehezkel Ben-Ari

Roustem Khazipov

Developmental Neuroplasticity: Roles in Early Life Seizures and Chronic Epilepsy

203

(24)

John W. Swann

Martha G. Pierson

Karen L. Smith

Chong L. Lee

Section III: The Idiopathic Epilepsies

Section III Introduction

219

(8)

Antonio V. Delgado-Escueta

Richard W. Olsen

Wilkie A. Wilson

Roger J. Porter

Single-Gene Models of Epilepsy

227

(12)

Jeffrey L. Noebels

Studies of the Lethargic (1h/1h) Mouse Model of Absence Seizures: Regulatory Mechanisms and Identification of the lh Gene

239

(14)

GABA Receptors in the 1h/1h Mouse Model of Absence Seizures

240

(7)

David A. Hosford

Fu-Hsiung Lin

Ying Wang

Sarah J. Caddick

Positional Cloning of the 1h Absence Disease Gene

247

(6)

Michele Rees

Nicholas J. Parkinson

Jane Barclay

Roger D. Cox

R. Mark Gardiner

David A. Hosford

Peter Denton

Ying Wang

Michael F. Seldin

Baowei Chen

Absence Epilepsy: Advances in Experimental Animal Models

253

(26)

O. Carter Snead III

Antoine Depaulis

Marguerite Vergnes

Christian Marescaux

Experimental Models of Multifactorial Epilepsies: The EL Mouse and Mice Susceptible to Audiogenic Seizures

279

(12)

Thomas N. Seyfried

Mariana Todorova

Michael J. Poderycki

Transgenic Approaches to Epilepsy

291

(6)

Miklos Toth

Laurence Tecott

Intrinsic Properties of Reticular Thalamic Neurons Relevant to Genetically Determined Spike-Wave Generation

297

(14)

Giuliano Avanzini

Marco de Curtis

Hans-Christian Pape

Roberto Spreafico

Neuronal Networks in the Genetically Epilepsy-Prone Rat

311

(12)

Carl Faingold

Genetic Epidemiology and the Search for Epilepsy Genes

323

(18)

Karen A. Weissbecker

Robert C. Elston

David Greenberg

Antonio V. Delgado-Escueta

Genes for Rare Idiopathic Generalized Epilepsies: BFNC

341

(10)

Nanda Singh

Carole Charlier

Andy Peiffer

Dora Stauffer

Roberta Melis

Mary-Anne Enoch

David Goldman

Scott Rogers

V. Elving Anderson

Mark Leppert

Mapping and Positional Cloning of Common Idiopathic Generalized Epilepsies: Juvenile Myoclonus Epilepsy and Childhood Absence Epilepsy

351

(24)

Antonio V. Delgado-Escueta

Marco T. Medina

Jose M. Serratosa

Ignacio Pascual Castroviejo

Manyee N. Gee

Karen A. Weissbecker

B.W.H. Westling

C.Y. Fong

Maria E. Alonso

Sergio Cordova

Pravina Shah

Sonia Khan

Jesus Sainz

F. Rubio-Donnadieu

Robert S. Sparkes

Genes of Partial Epilepsies

375

(8)

Samuel F. Berkovic

Ortrud K. Steinlein

The Molecular Genetic Basis of the Progressive Myoclonus Epilepsies

383

(16)

Jose M. Serratosa

R. Marc Gardiner

Anna-Elina Lehesjoki

Len A. Pennachio

Richard M. Myers

Dentatorubral-Pallidoluysian Atrophy (DRPLA): Clinical Features and Molecular Genetics

399

(12)

Shoji Tsuji

Mitochondrial Genes for Generalized Epilepsies

411

(10)

Salvatore DiMauro

Romana Kulikova

Kurenai Tanji

Eduardo Bonilla

Michio Hirano

Parental Imprinting and Angelman Syndrome

421

(20)

Marc Lalande

Berge A. Minassian

Timothy M. DeLorey

Richard W. Olsen

Section IV: Symptomatic Lesional Epilepsies

Overview Introduction

433

(4)

Antonio V. Delgado-Escueta

Roger J. Porter

IV-A. Neuronal channels, receptors and transporters: Molecular structure, gating, and pharmacology

Section IV-A Introduction

437

(4)

Richard W. Olsen

Antonio V. Delgado-Escueta

Molecular Properties of Brain Sodium Channels: An Important Target for Anticonvulsant Drugs

441

(16)

William A. Catterall

Chemical Modulation of Sodium Channels and GABAA Receptor Channel

457

(24)

Toshio Narahashi

Voltage-Dependent Activation of Ion Channels

481

(12)

Diane M. Papazian

Francisco Bezanilla

Membrane Properties and Epilepsy

493

(6)

Wayne E. Crill

Peter C. Schwindt

GABA Receptor Function and Epilepsy

499

(12)

Richard W. Olsen

Timothy M. DeLorey

Marina Gordey

Maeng-Hee Kang

Ligand-gated Channel: Postsynaptic Receptors and Drug Targets

511

(14)

Meyer B. Jackson

Glutamate Receptor Channels: A Possible Link between RNA Editing in the Brain and Epilepsy

525

(10)

Rolf Sprengel

Miyoko Higuchi

Hannah Monyer

Peter H. Seeburg

Antibodies to Glutamate Receptors: A Role in Excitatory Dysregulation of the Central Nervous System

535

(8)

Roy E. Twyman

Scott W. Rogers

Lorise C. Gahring

Noel G. Carlson

Sean D. Donevan

Evidence for Glutamate Receptor Autoimmunity in Pathogenesis of Rasmussen's Encephalitis

543

(8)

James O. McNamara

Karl D. Whitney

P. Ian Andrews

Xiao-Ping He

Sridevi Janumpalli

Manisha N. Patel

GABA and Glutamate Transporters: Therapeutic and Etiological Implications for Epilepsy

551

(14)

Vickie R. Roettger

Susan G. Amara

IV-B. Glia and Epilepsy

Section IV-B Introduction

561

(4)

Antonio V. Delgado-Escueta

Physiology of Glial Cells

565

(8)

Helmut Kettenmann

Modulation of Neuronal Excitability by Astrocytes

573

(10)

Steve Duffy

Brian A. MacVicar

Contribution of Astrocytes to Seizure Activity

583

(8)

U. Heinemann

Siegrun Gabriel

Sebastian Schuchmann

Claudia Eder

The Molecular Neuron-Glia Couple and Epileptogenesis

591

(16)

Thierry Grisar

Bernard Lakaye

Elizabeth Thomas

Lucien Bettendorf

Arlette Minet

IV-C: Initiation, Synchronization, and Spread of Epileptic Discharges

Section IV-C Introduction

603

(4)

Suzanne Clarke

Wilkie A. Wilson

Antonio V. Delgado-Escueta

Mechanisms of Epileptogenesis

607

(24)

Suzanne Clark

Wilkie A. Wilson

Synaptic Plasticity in Kindling

631

(14)

Istvan Mody

Presynaptic and Postsynaptic Mechanisms of Long-Term Potentiation

645

(14)

Asha Nayak

Michael D. Browning

Second Messengers, Long-Term Potentiation, Gene Expression, and Epileptogenesis

659

(6)

Nicolas G. Bazan

Michael J. Serou

Epileptogenic Neurons and Circuits

665

(20)

David A. Prince

Role of Metabotropic Glutamate Receptors in Epilepsy

685

(14)

Robert K.S. Wong

Riccardo Bianchi

Gregory W. Taylor

Lisa R. Merlin

Mechanisms of Neuronal Synchronization During Epileptiform Activity

699

(10)

F. Edward Dudek

Peter Patrylo

Jean-Pierre Wuarin

Functionally Relevant and Functionally Disruptive (Epileptic) Synchronized Oscillations in Brain Slices

709

(16)

Roger D. Traub

John G.R. Jefferys

Miles A. Whittington

Basic Mechanisms of Status Epilepticus

725

(12)

Douglas A. Coulter

Robert J. DeLorenzo

IV-D: Epileptic Cell Damage and Epileptogenesis

Section IV-D Introduction

735

(2)

Suzanne Clarke

Wilkie A. Wilson

Antonio V. Delgado-Escueta

Neurocytology of a Primate Model of Human Temporal Lobe Epilepsy

737

(6)

Charles E. Ribak

Roy A.E. Bakay

Neuronal Loss and Synaptic Reorganization in Temporal Lobe Epilepsy

743

(20)

Carolyn R. Houser

Synaptic Reorganizations in Human and Rat Hippocampal Epilepsy

763

(18)

Thomas L. Babb

Physiological and Anatomical Correlates of the Human Dentate Gyrus: Consequences or Causes of Epilepsy

781

(14)

Leona M. Masukawa

L.J. Burdette

P. McGonigle

H. Wang

W.O'Connor

M.R. Sperling

M.J.O'Connor

K. Uruno

Excitability Changes in Epileptic Human Dentate Gyrus and Temporal Neocortex

795

(10)

Anne Williamson

The Role of Nonprincipal Cells in Dentate Gyrus Excitability and its Relevance to Animal Models of Epilepsy and Temporal Lobe Epilepsy

805

(16)

Helen E. Scharfman

Excitation and Inhibition in Temporal Lobe Epilepsy: A Close Encounter

821

(8)

Christophe Bernard

June C. Hirsch

Yehezkel Ben-Ari

Seizure-Induced Hippocampal Damage and Chronic Epilepsy: A Hebbian Theory of Epileptogenesis

829

(16)

Claude G. Wasterlain

Andre M. Mazarati

Yukiyoshi Shirasaka

Kerry W. Thompson

LaRoy Penix

Hantao Liu

Hiroshi Katsumori

Epilepsy and the Blood Brain Barrier: Endothelial Cell Responses to Seizures

845

(28)

Eain M. Cornford

Section V: Frontiers in Brain Imaging and Therapeutics

Section V Introduction

865

(8)

William H. Theodore

Antonio V. Delgado-Escueta

Roger J. Porter

Cerebral Blood Flow and Glucose Metabolism in Human Epilepsy

873

(10)

William H. Theodore

Basic Mechanisms of Childhood Epilepsies: Studies with Positron Emission Tomography

883

(10)

Harry T. Chugani

Diane C. Chugani

Positron Emission Tomography Receptor Studies

893

(8)

John S. Duncan

Positron Emission Tomography: The Contribution of Cognitive Activation Paradigms to the Understanding of the Epilepsies

901

(16)

Barbara E. Swartz

Mark A. Mandelkern

New Nuclear Magnetic Resonance Measurements in Epilepsy: General Introduction, Functional Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, and Diffusion-Weighted Imaging

917

(8)

James W. Prichard

New Nuclear Magnetic Resonance Measurements in Epilepsy: Diffusion-Weighted Magnetic Resonance Imaging of Spreading Depression

925

(6)

Christopher H. Sotak

New Nuclear Magnetic Resonance Measurements in Epilepsy: T2 Relaxometry and Magnetic Resonance Spectroscopy

931

(8)

Graeme D. Jackson

Alan Connelly

New Nuclear Magnetic Resonance Measurements in Epilepsy: Measuring Brain GABA in Patients with Complex Partial Seizures

939

(8)

Ognen A. C. Petroff

Kevin L. Behar

Douglas L. Rothman

AMPA Receptors in Epilepsy and as Targets for Antiepileptic Drugs

947

(18)

Michael A. Rogawski

Sean D. Donevan

Excitatory Amino Acid Receptors and Antiepileptic Drug Development

965

(14)

Brain S. Meldrum

Astrid G. Champman

Pharmacological Properties of Recombinant and Hippocampal Dentate Granule Cell GABAA Receptors

979

(12)

Robert L. Macdonald

Jaideep Kapur

Neuronal Circuitry of Thalamocortical Epilepsy and Mechanisms of Anti-Absence Drug Action

991

(10)

John R. Huguenard

Adenosine and Suppression of Seizures

1001

(10)

Thomas V. Dunwiddie

Mechanisms of New Antiepileptic Drugs

1011

(16)

Charles P. Taylor

Genetic Analysis of Neuronal Physiology with Defective Herpes Simplex Virus Vectors

1027

(6)

Rachael L. Neve

Alfred I. Geller

Subject Index

1033

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Jasper's Basic Mechanisms of the Epilepsies

Jasper's Basic Mechanisms of the Epilepsies

9780781714389

0781714389

Summary

Table of Contents

Supplemental Materials

Write a Review

Amazon no longer offers textbook rentals. We do!

Jasper's Basic Mechanisms of the Epilepsies

Jasper's Basic Mechanisms of the Epilepsies

9780781714389

0781714389

Summary

Table of Contents

Supplemental Materials

Write a Review

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