Thoroughly updated for its Third Edition, this handbook is a comprehensive guide to the evaluation of more than 500 signs and symptoms. Each entry describes the sign or symptom and covers emergency interventions if needed, history and physical examination, medical and other causes, and special considerations such as tests, monitoring, and treatment. This edition identifies specific signs and symptoms caused by herbal medicines, biologic weapons, and emerging diseases such as listeriosis and Rift Valley fever. New icons highlight gender and cultural differences in signs and symptoms.