9781606235188

Bringing together foremost experts, this book reviews groundbreaking gene-environment research and explores implications for clinical practice, prevention, and public policy. Presented is cutting-edge work on the interplay of genetic factors and childhood experiences in the development of mental disorders such as depression, conduct disorder, and schizophrenia. Essential topics include what scientists currently know about "susceptibility genes"; the mechanisms by which maltreatment and other stressors interact with biological susceptibilities across development; and factors that make certain children more resilient than others. Future directions for personalizing treatment and prevention efforts, thus making them more effective, are discussed. This book will be important reading for developmental and clinical psychology researchers; epidemiologists; policymakers in the area of child and family health. It may also serve as a supplemental text in graduate-level courses.

Kenneth A. Dodge, PhD, is William McDougall Professor of Public Policy, Professor of Psychology and Neuroscience, and Director of the Center for Child and Family Policy at Duke University. His research focuses on how genes and environments interact to produce chronic antisocial behavior. He has used his research findings to create, implement, and evaluate preventive interventions for children and parents, and is currently interested in designing policies for communities to prevent violence. Dr. Dodge is a recipient of the Distinguished Scientific Contribution Award from the American Psychological Association and the Senior Scientist Award from the National Institutes of Health. Michael Rutter, MD, FRS, is Professor of Developmental Psychopathology at the Institute of Psychiatry, Kings College, London, United Kingdom. He has long been interested in gene–environment interdependence, has undertaken numerous studies of environmental influences on psychopathology, and has been involved in both behavioral genetic and molecular genetic studies of mental disorders. Throughout his research and clinical career, he has focused on research–clinical interplay and the policy implications of research findings. Dr. Rutter was knighted in 1992 and is an honorary member of the British Academy, a Fellow of the Royal Society, and founding Fellow of the Academia Europaea and the Academy of Medical Sciences.

I. Scientific Understanding 1. Gene–Environment Interplay: Scientific Issues and Challenges, Michael Rutter 2. Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits, Avshalom Caspi, Ahmad R. Hariri, Andrew Holmes, Rudolf Uher, and Terrie E. Moffitt 3. Neurobiological Mechanisms Supporting Gene–Environment Interaction Effects, Ahmad R. Hariri 4. Neurogenetic Mechanisms of Gene–Environment Interactions, Andreas Meyer-Lindenberg 5. Gene–Environment Interactions: State of the Science, Michael Rutter and Kenneth A. Dodge II. Practice and Policy 6. Marital Dynamics and Child Proaction: Genetics Takes a Second Look at Developmental Theory, David Reiss and Jenae M. Neiderhiser 7. Gene–Environment Interactions for Delinquency: Promises and Difficulties, Guang Guo 8. Genes, Environment, and Personalized Treatment for Depression, Rudolf Uher 9. Promoting Resilience in Maltreated Children, Joan Kaufman and Francheska Perpletchikova 10. Shaping Society through Social Policy: Will the Gene–Environment Revolution Make a Difference?, E. Jane Costello 11. Gene–Environment Interactions, Criminal Responsibility, and Sentencing, Stephen J. Morse 12. Gene–Environment Studies in the Era of Full-Genome Sequencing: Some Lessons from Eugenics and the Race–IQ Debates, Robert Cook-Deegan 13. Genes, Environments, and Public Policy, Kenneth A. Dodge and Michael Rutter

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Gene-Environment Interactions in Developmental Psychopathology

Gene-Environment Interactions in Developmental Psychopathology

1606235184

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