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Chapter 1. History of Drug Discovery 1
1. Introduction 1
2. Antibacterials 1
3. Cancer Drugs 6
4. Cardiovascular Drugs 10
5. Cholesterol Drugs 16
6. CNS Drugs 21
7. Anti-inflammatory Drugs 26
8. Anti-ulcer Drugs 30
9. Antiviral Drugs 33
10. References 38
Chapter 2. Target Identification and Validation 43
1. History 43
2. Definition of Drug Targets 43
3. Classification of Currently Utilized Drug Targets 45
4. Receptors as Drug Targets 46... MORE
JIE JACK LI, PhD, is a chemist at Bristol-Myers Squibb Company. He has authored or edited several books published by Wiley, including Name Reactions in Heterocyclic Chemistry, Name Reactions for Functional Group Transformations, Name Reactions for Homologations (Part I and Part II), Name Reactions for Carbocyclic Ring Formations, Contemporary Drug Synthesis, The Art of Drug Synthesis, and Modern Drug Synthesis.
E. J. COREY, PhD, has been a Professor at Harvard University since 1959. The 1990 Nobel Laureate in Chemistry, Dr. Corey has also been the recipient of more than seventy international awards and honorary degrees, including the U.S. National Medal of Science, the Japan Prize in Science, and the Priestley Medal. Author of more than 1,500 publications, he is one of the most cited authors in science.