9780721682334

The new edition of this text continues the tradition of delivering an accessible, engaging, and current introduction to this essential subject. It describes the principles of basic and applied immunology in a concise, straightforward manner, while incorporating a wealth of current information. Over 330 new, full-color illustrations help readers grasp important information quickly and easily.

Abul K. Abbas, MBBS: Professor and Chair, Department of Pathology, University of California-San Francisco School of Medicine, California Andrew H. Lichtman, MD, PhD: Associate Professor of Pathology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts

Section i Introduction to Immunology

1

(38)

General Properties of Immune Responses

3

(14)

Cells and Tissues of the Immune System

17

(22)

Section ii Recognition of Antigens

39

(84)

Antibodies and Antigens

41

(22)

The Major Histocompatibility Complex

63

(16)

Antigen Processing and Presentation to T Lymphocytes

79

(23)

Antigen Receptors and Accessory Molecules of T Lymphocytes

102

(21)

Section iii Maturation, Activation, and Regulation of Lymphocytes

123

(110)

Lymphocyte Maturation and Expression of Antigen Receptor Genes

125

(36)

Activation of T Lymphocytes

161

(21)

B Cell Activation and Antibody Production

182

(26)

Immunologic Tolerance

208

(25)

Section iv Effector Mechanisms of Immune Responses

233

(108)

Cytokines

235

(35)

Innate Immunity

270

(21)

Effector Mechanisms of Cell-Mediated Immunity

291

(18)

Effector Mechanisms of Humoral Immunity

309

(32)

The Immune Response: A Summary

335

(6)

Section v Immunity in Defense and Disease

341

(127)

Immunity to Microbes

343

(20)

Transplantation Immunology

363

(21)

Immunity to Tumors

384

(20)

Diseases Caused by Immune Resposes: Hypersensitivity and Autoimmunity

404

(20)

Immediate Hypersensitivity

424

(21)

Congenital and Acquired Immunodeficiencies

445

(23)

Appendix I Glossary

468

(32)

Appendix II Principal Features of CD Molecules

500

(15)

Appendix III Laboratory Techniques Commonly Used in Immunology

515

(14)

Index

529

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Cellular and Molecular Immunology

Cellular and Molecular Immunology

0721682332

Summary

Author Biography

Table of Contents

Supplemental Materials