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| Preface | p. xix |
| Acknowledgments | p. xxi |
| Guide to Using This Book | p. xxiii |
| The Central Nervous System | p. 1 |
| Introduction to the Central Nervous System | p. 3 |
| Neurons and Glia Are the Two Principal Cellular Constituents of the Nervous System | p. 4 |
| The Nervous System Consists of Separate Peripheral and Central Components | p. 6 |
| The Spinal Cord Displays the Simplest Org... MORE | p. 8 |
| The Brain Stem and Cerebellum Regulate Body Functions and Movements | p. 8 |
| The Diencephalon Consists of the Thalamus and Hypothalamus | p. 11 |
| The Cerebral Hemispheres Have the Most Complex Three-Dimensional Configuration of All Central Nervous System Divisions | p. 11 |
| Cavities Within the Central Nervous System Contain Cerebrospinal Fluid | p. 18 |
| The Central Nervous System Is Covered by Three Meningeal Layers | p. 19 |
| An Introduction to Neuroanatomical Terms | p. 21 |
| Summary | p. 25 |
| Structural and Functional Organization of the Central Nervous System | p. 27 |
| The Dorsal Column--Medial Lemniscal System and Corticospinal Tract Have a Component at Each Level of the Neuraxis | p. 28 |
| The Modulatory Systems of the Brain Have Diffuse Connections and Use Different Neurotransmitters | p. 29 |
| Guidelines for Studying the Regional Anatomy and Interconnections of the Central Nervous System | p. 32 |
| The Spinal Cord Has a Central Cellular Region Surrounded by a Region That Contains Myelinated Axons | p. 32 |
| Surface Features of the Brain Stem Mark Key Internal Structures | p. 34 |
| The Internal Capsule Contains Ascending and Descending Axons | p. 41 |
| Cerebral Cortex Neurons Are Organized Into Layers | p. 42 |
| The Cerebral Cortex Has an Input-Output Organization | p. 43 |
| The Cytoarchitectonic Map of the Cerebral Cortex Is the Basis for a Map of Cortical Function | p. 44 |
| Summary | p. 52 |
| Development of the Central Nervous System | p. 55 |
| The Neurons and Glial Cells Derive From Cells of the Neural Plate | p. 55 |
| The Neural Tube Forms Five Brain Vesicles and the Spinal Cord | p. 57 |
| The Spinal Cord and Brain Stem Have a Segmented Structure | p. 59 |
| The Location of Developing Spinal Cord and Brain Stem Nuclei Determine Their Functions and Connections | p. 63 |
| The Cerebellum Develops From the Rhombic Lips | p. 69 |
| The Rostral Portion of the Neural Tube Gives Rise to the Diencephalon and Cerebral Hemispheres | p. 69 |
| Summary | p. 78 |
| Vasculature of the Central Nervous System and the Cerebrospinal Fluid | p. 81 |
| Neural Tissue Depends on Continuous Arterial Blood Supply | p. 82 |
| The Vertebral and Carotid Arteries Supply Blood to the Central Nervous System | p. 83 |
| The Spinal and Radicular Arteries Supply Blood to the Spinal Cord | p. 85 |
| The Vertebral and Basilar Arteries Supply Blood to the Brain Stem | p. 86 |
| The Internal Carotid Artery Has Four Principal Portions | p. 86 |
| The Anterior and Posterior Circulations Supply the Diencephalon and Cerebral Hemispheres | p. 86 |
| Cerebral Veins Drain Into the Dural Sinuses | p. 92 |
| The Blood-Brain Barrier Isolates the Chemical Environment of the Central Nervous System From That of the Rest of the Body | p. 96 |
| Cerebrospinal Fluid Serves Many Diverse Functions | p. 97 |
| Summary | p. 102 |
| Sensory Systems | p. 105 |
| Spinal Somatic Sensory Systems | p. 107 |
| Functional Anatomy of the Spinal Somatic Sensory Pathways | p. 107 |
| The Dorsal Column--Medial Lemniscal System and the Anterolateral System Mediate Different Somatic Sensations | p. 108 |
| The Two Ascending Somatic Sensory Pathways Each Receive Inputs From Different Classes of Sensory Receptor Neurons | p. 109 |
| The Somatic Sensory Pathways Have Different Relay Nuclei in the Spinal Cord and Brain Stem | p. 109 |
| The Two Ascending Somatic Sensory Pathways Decussate at Different Levels of the Neuraxis | p. 109 |
| The Dorsal Column--Medial Lemniscal and Anterolateral Systems Synapse in Different Brain Stem, Diencephalic, and Cortical Regions | p. 109 |
| Regional Anatomy of the Spinal Somatic Sensory Pathways | p. 111 |
| The Peripheral Axon Terminals of Dorsal Root Ganglion Neurons Contain the Somatic Sensory Receptor | p. 114 |
| Dorsal Root Axons With Different Diameters Terminate in Different Central Nervous System Locations | p. 117 |
| The Dorsal Columns Contain Ascending Branches of Mechanoreceptive Sensory Fibers | p. 119 |
| The Somatotopic Organization of the Dorsal Columns Is Revealed in Human Postmortem Specimens | p. 119 |
| The Decussation of the Dorsal Column--Medial Lemniscal System Is in the Caudal Medulla | p. 120 |
| Vascular Lesions of the Medulla Differentially Affect Somatic Sensory Function | p. 124 |
| Descending Pain Suppression Pathways Originate From the Brain Stem | p. 124 |
| Three Separate Nuclei in the Thalamus Process Somatic Sensory Information | p. 125 |
| Several Areas of the Parietal Lobe Process Touch and Proprioceptive Information | p. 126 |
| Limbic and Insular Areas Contain the Cortical Representations of Pain, Itch, and Temperature Sensations | p. 130 |
| Summary | p. 131 |
| Cranial Nerves and the Trigeminal and Viscerosensory Systems | p. 135 |
| Cranial Nerves and Nuclei | p. 135 |
| Important Differences Exist Between the Sensory and Motor Innervation of Cranial Structures and That of the Limbs and Trunk | p. 137 |
| There Are Seven Functional Categories of Cranial Nerves | p. 137 |
| Cranial Nerve Nuclei Are Organized Into Rostrocaudal Columns | p. 140 |
| Functional Anatomy of the Trigeminal and Viscerosensory Systems | p. 140 |
| Separate Trigeminal Pathways Mediate Touch and Pain and Temperature Senses | p. 143 |
| The Viscerosensory System Originates from the Caudal Solitary Nucleus | p. 145 |
| Regional Anatomy of the Trigeminal and Viscerosensory Systems | p. 145 |
| Separate Sensory Roots Innervate Different Parts of the Face and Mucous Membranes of the Head | p. 145 |
| The Key Components of the Trigeminal System Are Present at All Levels of the Brain Stem | p. 146 |
| The Caudal Solitary and Parabrachial Nuclei Are Key Brain Stem Viscerosensory Integrative Centers | p. 155 |
| The Ventral Posterior Nucleus Contains Separate Trigeminal and Spinal Subdivisions and Projects to the Postcentral Gyrus | p. 155 |
| The Thalamic Viscerosensory Relay Nucleus Projects to the Insular Cortex | p. 157 |
| Summary | p. 158 |
| The Visual System | p. 161 |
| Functional Anatomy of the Visual System | p. 161 |
| Anatomically Separate Visual Pathways Mediate Perception and Ocular Reflex Function | p. 161 |
| The Pathway to the Primary Visual Cortex Is Important for Perception of the Form, Color, and Motion of Visual Stimuli | p. 162 |
| The Pathway to the Midbrain Is Important in Voluntary and Reflexive Control of the Eyes | p. 162 |
| Regional Anatomy of the Visual System | p. 162 |
| Optical Properties of the Eye Transform Visual Stimuli | p. 162 |
| The Retina Contains Five Major Layers | p. 165 |
| Each Optic Nerve Contains All of the Axons of Ganglion Cells in the Ipsilateral Retina | p. 169 |
| The Superior Colliculus Is Important in Oculomotor Control and Orientation | p. 169 |
| The Retinotopic Maps in Each Layer of the Lateral Geniculate Nucleus Are Aligned | p. 171 |
| The Primary Visual Cortex Is the Target of Projections From the Lateral Geniculate Nucleus | p. 173 |
| The Magnocellular and Parvocellular Systems Have Differential Laminar Projections in the Primary Visual Cortex | p. 173 |
| The Primary Visual Cortex Has a Columnar Organization | p. 176 |
| Higher-Order Visual Cortical Areas Analyze Distinct Aspects of Visual Stimuli | p. 180 |
| The Visual Field Changes in Characteristic Ways After Damage to the Visual System | p. 184 |
| Summary | p. 187 |
| The Auditory System | p. 191 |
| Functional Anatomy of the Auditory System | p. 192 |
| Parallel Ascending Auditory Pathways May Be Involved in Different Aspects of Hearing | p. 192 |
| Regional Anatomy of the Auditory System | p. 194 |
| The Auditory Sensory Organs Are Located Within the Membranous Labyrinth | p. 194 |
| The Topography of Connections Between Brain Stem Auditory Nuclei Provides Insight Into the Functions of Parallel Ascending Auditory Pathways | p. 196 |
| The Olivocochlear System May Regulate Hair Cell Sensitivity | p. 198 |
| Auditory Brain Stem Axons Ascend in the Lateral Lemniscus | p. 199 |
| The Inferior Colliculus Is Located in the Midbrain Tectum | p. 199 |
| The Medial Geniculate Nucleus Contains a Division That Is Tonotopically Organized | p. 200 |
| The Auditory Cortical Areas Are Located on the Superior Surface of the Temporal Lobe | p. 201 |
| Summary | p. 204 |
| Chemical Senses: Taste and Smell | p. 207 |
| The Gustatory System: Taste | p. 208 |
| The Ascending Gustatory Pathway Projects to the Ipsilateral Insular Cortex | p. 208 |
| Regional Anatomy of the Gustatory System | p. 210 |
| Branches of the Facial, Glossopharyngeal, and Vagus Nerves Innervate Different Parts of the Oral Cavity | p. 210 |
| The Solitary Nucleus Is the First Central Nervous System Relay for Taste | p. 211 |
| The Parvocellular Portion of the Ventral Posterior Medial Nucleus Relays Gustatory Information to the Insular Cortex and Operculum | p. 212 |
| The Olfactory System: Smell | p. 216 |
| The Olfactory Projection to the Cerebral Cortex Does Not Relay in the Thalamus | p. 216 |
| Regional Anatomy of the Olfactory System | p. 216 |
| The Primary Olfactory Neurons Are Located in the Nasal Mucosa | p. 216 |
| The Olfactory Bulb Is the First Central Nervous System Relay for Olfactory Input | p. 219 |
| The Olfactory Bulb Projects to Structures on the Ventral Brain Surface Through the Olfactory Tract | p. 219 |
| The Primary Olfactory Cortex Receives a Direct Input From the Olfactory Bulb | p. 219 |
| Projections From the Olfactory Bulb to the Cortex Have a Parallel Organization | p. 222 |
| Summary | p. 224 |
| Motor Systems | p. 227 |
| Descending Motor Pathways and the Motor Function of the Spinal Cord | p. 229 |
| Functional Anatomy of the Motor Systems and the Descending Motor Pathways | p. 230 |
| Diverse Central Nervous System Structures Comprise the Motor Systems | p. 230 |
| Many Cortical Regions Are Recruited Into Action During Visually Guided Movements | p. 231 |
| There Are Three Functional Classes of Descending Pathways | p. 232 |
| Multiple Parallel Motor Control Pathways Originate From the Cortex and Brain Stem | p. 232 |
| Motor Pathways of the Spinal Cord Have a Hierarchical Organization | p. 232 |
| The Functional Organization of the Descending Pathways Parallels the Somatotopic Organization of the Motor Nuclei in the Ventral Horn | p. 234 |
| Regional Anatomy of the Motor Systems and the Descending Motor Pathways | p. 235 |
| The Cortical Motor Areas Are Located in the Frontal Lobe | p. 239 |
| The Projection From Cortical Motor Regions Passes Through the Internal Capsule En Route to the Brain Stem and Spinal Cord | p. 243 |
| The Corticospinal Tract Courses in the Base of the Midbrain | p. 247 |
| Descending Cortical Fibers Separate Into Small Fascicles in the Ventral Pons | p. 247 |
| The Pontine and Medullary Reticular Formation Gives Rise to the Reticulospinal Tracts | p. 247 |
| The Lateral Corticospinal Tract Decussates in the Caudal Medulla | p. 248 |
| The Intermediate Zone and Ventral Horn of the Spinal Cord Receive Input From the Descending Pathways | p. 248 |
| Lesions of the Descending Cortical Pathway in the Brain and Spinal Cord Produce Flaccid Paralysis Followed by Spasticity | p. 250 |
| Summary | p. 255 |
| Cranial Nerve Motor Nuclei and Brain Stem Motor Functions | p. 259 |
| Organization and Functional Anatomy of Cranial Motor Nuclei | p. 260 |
| There Are Three Columns of Cranial Nerve Motor Nuclei | p. 260 |
| The Cranial Motor Nuclei Are Controlled by the Cerebral Cortex and Diencephalon | p. 260 |
| Neurons in the Somatic Skeletal Motor Column Innervate the Tongue and Extraocular Muscles | p. 260 |
| The Branchiomeric Motor Column Innervates Skeletal Muscles That Develop From the Branchial Arches | p. 263 |
| The Autonomic Motor Column Contains Parasympathetic Preganglionic Neurons | p. 266 |
| Regional Anatomy of Cranial Motor Nuclei | p. 269 |
| Lesion of the Genu of the Internal Capsule Interrupts the Corticobulbar Tract | p. 269 |
| Parasympathetic Neurons in the Midbrain Regulate Pupil Size | p. 270 |
| The Descending Cortical Fibers Break Up Into Small Fascicles in the Pons | p. 273 |
| The Trigeminal Motor Nucleus Is Medial to the Main Trigeminal Sensory Nucleus | p. 273 |
| The Fibers of the Facial Nerve Have a Complex Trajectory Through the Pons | p. 273 |
| The Glossopharyngeal Nerve Enters and Exits From the Rostral Medulla | p. 275 |
| A Level Through the Midmedulla Reveals the Locations of Six Cranial Nerve Nuclei | p. 276 |
| The Spinal Accessory Nucleus Is Located at the Junction of the Spinal Cord and Medulla | p. 277 |
| Summary | p. 278 |
| The Vestibular and Oculomotor Systems | p. 281 |
| Functional Anatomy of the Vestibular System | p. 282 |
| An Ascending Pathway From the Vestibular Nuclei to the Thalamus Is Important for Perception and Orientation | p. 282 |
| The Vestibular Nuclei Have Functionally Distinct Efferent Projections for Axial Muscle Control and Perception | p. 283 |
| Functional Anatomy of the Oculomotor System and the Control of Gaze | p. 283 |
| The Extraocular Motor Neurons Are Located in Three Cranial Nerve Motor Nuclei | p. 283 |
| Voluntary Eye Movement Direction Is Controlled by Neurons in the Frontal Lobe and the Parietal-Temporal-Occipital Association Cortex | p. 283 |
| The Vestibuloocular Reflex Maintains Direction of Gaze During Head Movement | p. 289 |
| Regional Organization of the Vestibular and Oculomotor Systems | p. 289 |
| Vestibular Nerve Fibers Project to the Vestibular Nuclei and the Cerebellum | p. 289 |
| The Vestibular Nuclei Have Functionally Diverse Projections | p. 289 |
| The Extraocular Motor Nuclei Are Located in the Pons and Midbrain | p. 293 |
| Rostral Midbrain Neurons Organize Vertical Saccades | p. 295 |
| Eye Movement Control Involves the Integrated Functions of Many Brain Stem Structures | p. 296 |
| The Ventral Posterior Nucleus of the Thalamus Transmits Vestibular Information to the Parietal and Insular Cortical Areas | p. 298 |
| Multiple Areas of the Cerebral Cortex Function in Eye Movement Control | p. 298 |
| Summary | p. 298 |
| The Cerebellum | p. 301 |
| Gross Anatomy of the Cerebellum | p. 301 |
| Functional Anatomy of the Cerebellum | p. 304 |
| All Three Functional Divisions of the Cerebellum Display a Similar Input-Output Organization | p. 304 |
| Regional Anatomy of the Cerebellum | p. 311 |
| The Intrinsic Circuitry of the Cerebellar Cortex Is Similar for the Different Functional Divisions | p. 312 |
| Spinal Cord and Medullary Sections Reveal Nuclei and Paths Transmitting Somatic Sensory Information to the Cerebellum | p. 315 |
| The Inferior Olivary Nucleus Is the Only Source of Climbing Fibers | p. 318 |
| The Vestibulocerebellum Receives Input From Primary and Secondary Vestibular Neurons | p. 318 |
| The Pontine Nuclei Provide the Major Input to the Cerebrocerebellum | p. 318 |
| The Deep Cerebellar Nuclei Are Located Within the White Matter | p. 319 |
| The Superior Cerebellar Peduncle Decussates in the Caudal Midbrain | p. 319 |
| The Ventrolateral Nucleus Relays Cerebellar Output to the Premotor and Primary Motor Cortical Areas | p. 321 |
| Summary | p. 324 |
| The Basal Ganglia | p. 327 |
| Functional Anatomy of the Basal Ganglia | p. 328 |
| Separate Components of the Basal Ganglia Process Incoming Information and Mediate the Output | p. 328 |
| Parallel Circuits Course Through the Basal Ganglia | p. 330 |
| Knowledge of Basal Ganglia Connections and Neurotransmitters Provides Insight Into Their Function in Health and Disease | p. 330 |
| Regional Anatomy of the Basal Ganglia | p. 334 |
| The Anterior Limb of the Internal Capsule Separates the Head of the Caudate Nucleus From the Putamen | p. 334 |
| Cell Bridges Link the Caudate Nucleus and the Putamen | p. 338 |
| The External Segment of the Globus Pallidus and the Ventral Pallidum Are Separated by the Anterior Commissure | p. 341 |
| The Ansa Lenticularis and the Lenticular Fasciculus Are Output Paths of the Internal Segment of the Globus Pallidus | p. 342 |
| Lesion of the Subthalamic Region Produces Hemiballism | p. 343 |
| The Substantia Nigra Contains Two Anatomical Divisions | p. 343 |
| The Vascular Supply of the Basal Ganglia Is Provided by the Middle Cerebral Artery | p. 346 |
| Summary | p. 347 |
| Integrative Systems | p. 349 |
| The Hypothalamus and Regulation of Endocrine and Visceral Functions | p. 351 |
| Functional Anatomy of the Neuroendocrine Systems | p. 353 |
| The Hypothalamus Is Divided Into Three Functionally Distinct Mediolateral Zones | p. 353 |
| Separate Parvocellular and Magnocellular Neurosecretory Systems Regulate Hormone Release From the Anterior and Posterior Lobes of the Pituitary | p. 355 |
| Functional Anatomy of Autonomic Nervous System Control | p. 358 |
| The Parasympathetic and Sympathetic Divisions of the Authonomic Nervous System Originate From Different Central Nervous System Locations | p. 358 |
| Hypothalamic Nuclei Coordinate Integrated Responses to Body and Environmental Stimuli via Local Circuits and Descending Visceral Motor Pathways | p. 359 |
| Regional Anatomy of the Hypothalamus | p. 363 |
| The Preoptic Area Influences Release of Reproductive Hormones From the Anterior Pituitary | p. 363 |
| The Supraoptic and Paraventricular Nuclei Comprise the Magnocellular Neurosecretory System | p. 364 |
| The Suprachiasmatic Nucleus Is the Master Clock for Circadian Rhythms | p. 366 |
| Parvocellular Neurosecretory Neurons Project to the Median Eminence | p. 366 |
| The Posterior Hypothalamus Contains the Mammillary Bodies | p. 367 |
| Neurons in the Lateral Hypothalamic Area Can Have Widespread Effects on Cortical Neuron Function | p. 367 |
| Descending Autonomic Fibers Course in the Periaqueductal Gray Matter and in the Lateral Tegmentum | p. 370 |
| Nuclei in the Pons Are Important for Bladder Control | p. 370 |
| Dorsolateral Brain Stem Lesions Interrupt Descending Sympathetic Fibers | p. 372 |
| Preganglionic Neurons Are Located in the Lateral Intermediate Zone of the Spinal Cord | p. 374 |
| Summary | p. 374 |
| The Limbic System and Cerebral Circuits for Emotions, Learning, and Memory | p. 377 |
| Anatomical and Functional Overview of Neural Systems for Emotions, Learning, and Memory | p. 378 |
| The Limbic Association Cortex Is Located on the Medial Surface of the Frontal, Parietal, and Temporal Lobes | p. 381 |
| The Hippocampal Formation Plays a Role in Memory Consolidation | p. 382 |
| The Amygdala Contains Three Major Functional Divisions | p. 386 |
| Connections Exist Between Components of the Limbic System and the Effector Systems | p. 388 |
| All Major Neurotransmitter Regulatory Systems Have Projections to the Limbic System | p. 389 |
| Regional Anatomy of Neural Systems for Emotions, Learning, and Memory | p. 392 |
| The Nucleus Accumbens and Olfactory Tubercle Comprise Part of the Basal Forebrain | p. 393 |
| Basal Forebrain Cholinergic Systems Have Diffuse Limbic and Neocortical Projections | p. 393 |
| The Cingulum Courses Beneath the Cingulate and Parahippocampal Gyri | p. 394 |
| The Three Nuclear Divisions of the Amygdala Are Revealed in Coronal Section | p. 395 |
| The Hippocampal Formation Is Located in the Floor of the Inferior Horn of the Lateral Ventricle | p. 397 |
| A Sagittal Cut Through the Mammillary Bodies Reveals the Fornix and Mammillothalamic Tract | p. 401 |
| Nuclei in the Brain Stem Link Telencephalic and Diencephalic Limbic Structures With the Autonomic Nervous System and the Spinal Cord | p. 403 |
| Summary | p. 403 |
| Atlas | p. 407 |
| Surface Topography of the Central Nervous System | p. 409 |
| Myelin-Stained Sections Through the Central Nervous System | p. 425 |
| Glossary | p. 489 |
| Index | p. 511 |
| Table of Contents provided by Rittenhouse. All Rights Reserved. |