9783527328413

Focusing on the materials suitable for biosensor applications, such as nanoparticles, quantum dots, meso- and nanoporous materials and nanotubes, this text enables the reader to prepare the respective nanomaterials for use in actual devices by appropriate functionalization, surface processing or directed self-assembly. The main detection methods used are electrochemical, optical, and mechanical, providing solutions to challenging tasks. The result is a reference for researchers and developers, disseminating first-hand information on which nanomaterial is best suited to a particular application -- and why.

TERM	PRICE	DUE
SEMESTER	$146.91	Aug 02
QUARTER	$139.56	Jul 19
SHORT TERM	$132.21	Jun 21

Dr. Songjun Li currently serves as president of the International Association of Advanced Materials and Editor-in-Chief of the international Journal Advanced Materials Letters. He is also Chair of the 1st International Congress on Advanced Materials, 13-16 May 2011, Jinan, China. Since his PhD in polymer chemistry, received from Chinese Academy of Sciences, his scientific interests focus on the chemistry of biosensors and molecularly imprinted polymers. Dr. Li was appointed by the Central China Normal University as an associate professor of chemistry in 2005. He was further appointed as an invited professor by the University of Jinan China in 2009 and a part-time professor by Jiangsu University in 2010. He is currently the specially appointed professor in the University of Allahabad India. Jagdish Singh is Professor and Chair of the Department of Pharmaceutical Sciences at NDSU College of Pharmacy, North Dakota, USA, and Fellow of the American Association of Pharmaceutical Scientists AAPS. His research efforts focus on the mechanistic studies for developing and testing novel methods to deliver biotechnology-derived molecules. Jagdish Singh received twice the NDSU College of Pharmacy Researcher of the Year awards and was recognized with the Fred Waldron Research Award in 2002 in recognition of his outstanding contributions to research and creative activities at NDSU. Dr. He Li, associated editor for Advanced Materials Letters, is an associate Professor of Chemistry in the School of Medical and Life Sciences at University of Jinan UJN, China. He got his PhD degree in 2004 in Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences. Subsequently, he was appointed by UJN as an associate professor with research interests in biosensors and nanomedicine. He worked as the dean of Pharmaceutical Engineering Department of UJN since 2007. Ipsita A. Banerjee is an Associate Professor of Chemistry at Fordham University, New York, USA She did her Ph.D in Chemistry from the University of Connecticut, USA and Postdoctoral research from the University of Notre Dame, South Bend, Indiana and from Hunter College, City University of New York in Bionanotechnology. Her research efforts are geared toward the study of mole cular self-assembly and formation of supramolecular nano-structures for the development of biomaterials for tissue-en gineering, and biosensors particularly for examining cellular interactions in vitro. Efforts are also on going for the green synthesis of nanoparticles for optoelectronics applications.

Preface	p. xi
List of Contributors	p. xv
New Micro and Nanotechnologies for Electrochemical Biosensor Development	p. 7
Introduction	p. 1
Carbon Nanorubes	p. 3
Carbon Nanorubes Used in Catalytic Biosensors	p. 4
Carbon Nanorubes Used in Affinity Biosensors	p. 10
Conductive Polymer Nanostructures	p. 15
Conductive Polymer Nanostructures Used in Catalytic Biosensors	p. 15
Conductive Polymer Nanostructures Used in Affinity Biosensors	p. 20
Nanoparticles	p. 23
Nanoparticles Used in Catalytic Biosensors	p. 23
Nanopartides Used in Affinity Biosensors	p. 24
Condusions	p. 30
References	p. 30
Advanced Nanoparticles in Medical Biosensors	p. 37
Introduction	p. 37
Nanopartides	p. 39
Gold Nanopartides	p. 39
Magnetic Nanopartides	p. 43
Quantum Dots	p. 44
Silica Based Nanopartides	p. 47
Dendrimers	p. 48
Fullerenes	p. 50
Condusions and Outlook	p. 52
References	p. 53
Smart Polymeric Nanofibers Resolving Biorecognition Issues	p. 57
Introduction	p. 57
Nanofibers	p. 60
pH-Sensitive Nanofibers	p. 61
Temperature-Responsive Nanofibers	p. 61
Electoospinning of Nanofibers	p. 62
Biorecognition Devices	p. 64
Conclusions	p. 69
References	p. 70
Fabrication and Evaluation of Nanoparticle-Based Biosensors	p. 73
Introduction	p. 73
Nanoparticle-Based Biosensors and their Fabrication	p. 74
Types of Nanobiosensors	p. 74
Electrochemical Biosensors	p. 75
Calorimerric Biosensors	p. 76
Optical Biosensors	p. 76
Piezoelectric Biosensors	p. 78
Fabrication of Biosensors	p. 78
Irrrmobilization of Biomolecules	p. 78
Conjugation of Biomolecules and Nanomaterials	p. 80
Newer Nanobiosensing Technologies	p. 80
Evaluation of Nanoparticle-Based Nanosensors	p. 82
Structural Characterization of Nanoparticle Based Biosensors	p. 82
Scartning Electron Microscopy	p. 82
Transmission Electron Microscopy	p. 83
Atomic Force Microscopy	p. 84
X Ray Diffraction	p. 84
X Ray Photoelectron Spectroscopy	p. 85
UV Visible Spectroscopy	p. 85
Functional Characterization of Nanoparticle-Based Biosensors	p. 86
Quartz Crystal Microbalance	p. 86
Ellipsometry	p. 86
Surface Plasmon Resonance	p. 87
Cyclic Voltammetry	p. 87
Applications of Nanoparticle-Based Biosensors	p. 88
Conclusions	p. 89
References	p. 89
Enzyme Based Biosensors: Synthesis and Applications	p. 95
Introduction	p. 95
Synthesis and Characterization of Biosensor Supports	p. 96
Carbon Nanotubes	p. 98
Characterization of Carbon Nanotubes	p. 98
Application of Carbon Nanotubes as Biosensor Supports	p. 99
Nanoparticles for Enzyme Immobilization	p. 100
General Consideration	p. 100
Application of Nanoparticles as Biosensor Supports	p. 101
Polymer Membranes	p. 102
Application of Enzyme-Based Biosensors	p. 104
Environmental Monitoring	p. 104
Phenolic Derivatives	p. 104
Pesticides	p. 105
Medical Diagnostics	p. 107
Conclusions	p. 109
Acknowledgments	p. 109
References	p. 109
Energy Harvesting for Biosensors Using Biofriendly Materials	p. 177
Introduction	p. 117
What is a Sensor?	p. 117
Why are We Moving Towards Biofriendly Materials?	p. 118
Why are We Moving Towards Energy Harvesting?	p. 118
Energy Production and. Consumption	p. 118
Classification of Energy-Harvesting Devices	p. 119
Conclusions	p. 124
References	p. 125
Carbon Nanotubes: In Vitro and In Vivo Sensing and Imaging	p. 127
Introduction	p. 127
Carbon Nanotubes: Structure, Physical and Chemical Properties, and Applications	p. 128
Near-IR Absorption of Carbon Nanotubes	p. 132
Near-IR Photoluminescence of Single-Walled Carbon Nanotubes	p. 134
Study Internalization Mechanism and In Vitro, In Vivo, and Long Term Fate of Carbon Nanotubes	p. 136
In Vitro and In Vivo Molecular Detection and Imaging	p. 138
Molecular Detection and Imaging Based on the Intrinsic Near-IR Fluorescence: Immunoassay	p. 138
Near-IR Photoluminescence Transduction Based on Band Gap Modulation of Single-Walled Carbon Nanotubes	p. 140
Other Sensing and Imaging Mechanisms	p. 144
Raman Scattering of Carbon Nanotubes	p. 145
Molecule Sensing and Imaging Based on Carbon Nanotube Raman Scattering	p. 147
Study of Internalization, In Vitro Cellular and In Vivo Tissue Biodistribution, and Long-Term Fate	p. 149
Conclusions and Outlook	p. 155
Acknowledgments	p. 155
References	p. 156
Lipid Nanoparticle Mediated Detection of Proteins	p. 161
Introduction to Liposomes	p. 162
Saturated Liposomes	p. 162
Detection of Antigens	p. 162
Detection of Viruses	p. 167
Detection of Enzymes	p. 169
Polymerized Liposomes	p. 169
Detection of Viruses	p. 170
Detection of Antigens	p. 172
Detection of Proteins	p. 173
Conclusions	p. 174
References	p. 174
Nanomaterials for Optical Imaging	p. 177
Introduction	p. 177
Doped Nanoparticles	p. 178
Doped Nanoparticles for In Vivo Imaging	p. 178
Quantum Dots	p. 180
Application of Quantum Dots for In Vivo Imaging	p. 182
Gold Nanoparticles	p. 182
Application of Gold Nanoparticles in Fluorescence Imaging	p. 185
Application of Gold Nanoparticles in Photoacoustic Imaging	p. 186
Lipid Based Nanoparticles	p. 188
Liposomes as Imaging Carriers	p. 188
Biomolecules	p. 190
Conclusions and Outlook	p. 192
Acknowledgments	p. 192
References	p. 192
Semiconductor Quantum Dots for Electrochemical Biosensors	p. 199
Introduction	p. 199
Attachment of Biomolecules to Quantum Dots	p. 200
Quantum Dot Based Redox Proteins Biosensor	p. 200
Glucose Oxidase Quantum Dot Based Glucose Biosensor	p. 200
Hemoglobin Quantum Dot Based H2O2 Biosensor	p. 204
Myoglobin-Quantum Dot Based H2O2 Biosensor	p. 208
Laccase Quantum Dot Based Ascorbic Acid Biosensor	p. 211
Acetylcholinesterase Quantum Dot-Based Inhibitor Biosensor	p. 211
Quantum Dot Based Electrochemical Biosensors of Proteins and DNA	p. 213
Conclusions	p. 217
References	p. 218
Functionalized Graphene for Biosensing Applications	p. 221
Introduction	p. 221
Preparation of Grapheme	p. 221
Functionalized Graphene with Metal Nanoparticles	p. 224
Glucose Biosensors Based on Graphene	p. 225
Immunosensors Based on Graphene	p. 228
Other Electrochemical Biosensors Based on Graphene	p. 229
Conclusions	p. 233
References	p. 234
Current Frontiers in Electrochemical Biosensors Using Chitosan Nanocomposites	p. 237
Introduction	p. 237
Chitosan	p. 238
Chitosan Nahocomposite-Based Electrochemical Biosensors	p. 240
Chitosan Nanocomposite Based Amperometric Biosensors	p. 240
Chitosan Nanocomposite Based Potentiometric Biosensors	p. 242
Chitosan Nanocomposite Based Conductimetric Biosensors	p. 244
Conclusions and Future Aspects	p. 245
References	p. 245
Nanomaterials as Promising DNA Biosensors	p. 247
Introduction	p. 247
Nanomaterials as Signal Amplifiers for Hybridization	p. 248
Nanoparticles	p. 248
Gold Nanoparticles	p. 249
Silver Nanoparticles	p. 249
Cadmium Sulfide Nanoparticles	p. 250
Quantum Dots	p. 250
Carbon Nanotube Based Electrochemical DNA Sensors	p. 251
Conclusions	p. 252
References	p. 253
Nanocomposites and their Biosensor Applications	p. 255
Introduction	p. 255
Nanocomposites	p. 256
Ceramic Matrix Nanocomposites	p. 257
Metal Matrix Nanocomposites	p. 258
Polymer Matrix Nanocomposites	p. 258
Biosensors	p. 259
Types of Biosensors	p. 261
Electrochemical	p. 262
Potentiometric	p. 262
Conductrmetric	p. 262
Amperometric	p. 263
Thermal Detection	p. 263
Ion Sensitive	p. 263
Optical Detection	p. 263
Resonant	p. 264
Biosensors Applications	p. 264
Nanocomposites for Biosensor Applications	p. 264
Conclusions	p. 266
References	p. 266
Index	p. 269
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Biosensor Nanomaterials

Biosensor Nanomaterials

3527328416

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