What do you call an architecture firm that draws inspiration from the most extreme aspects of nature and human psychology? When faced with this challenge in 1989, architect Franccedil;ois Roche decided that the best way to express his firm's design philosophy would be to change its name every few years. Presently, the Paris-based practice goes by the name of R&Sie(n). Pronounced 'heresy' in French, the firm's radical approach-what they refer to as a 'chameleon strategy'-permeates everything they do, right down to their gender-bending, morphed anti publicity photo. Led by Roche, R&Sie(n)'s investigative approach to architecture focuses on developing technological experiments-cartographic distortions and territorial mutations-in order to explore the bond between building, context, and human relations. Each building is a process, a dynamic device with the tenacity of a parasite that uses every means offered by architecture to perform an ecologically useful function. Bioreboot features nineteen projects-illustrated with extensive plans, photographs, and renderings-along with essays and interviews, providing the most comprehensive monograph of this elusive, intriguing firm to date. Despite working with oppositional relationships-machinery versus nature, purity versus corruption, paranoia versus rationality-theirs is an architecture whose primary aim is the ecological and social improvement of the place in which it exists. The 2003 Mosquito Bottleneck project mixes objective paranoia with a desire for safety. Designed as a trap for dangerous, West Nile Fever-infected mosquitos, the intestinelike private home in Trinidad weaves together all of its surfaces-floor, facade, and roof-with plastic wire and shrink-wrap. (Un)Plug, a speculative skyscraper project commissioned in 2000 by the Parisian electricity company EDF, features a glass facade of swelling, photoelectric pustules that allow the building to gain enough solar energy to disconnect from the urban energy grid. Bioreboot is a thought-provoking leap into the future and a clarion call for the development of a new relationship between contemporary architecture and the world of nature.