Biochemistry : Essential Concepts
ISBN: 9780199765621 | 0199765626
Format: PaperbackPublisher: Oxford Univ Pr
Pub. Date: 6/15/2012
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Biochemical Bottom Lines is a concise and manageable presentation of the basic biochemical principles together with problem-solving and review tools that keeps students focused on the essential concepts they need to learn. Designed to supplement any traditional biochemistry text but substantial enough to stand on its own, Charles Hardin's Biochemical Bottom Lines offers students and professors alike flexibility in teaching and learning one-semesterbiochemistry.
One-semester biochemistry courses are notorious for ov... MORE
One-semester biochemistry courses are notorious for ov... MORE
| Brief Contents | |
| Preface | |
| Acknowledgement | |
| Biochemistry: Subject Overview | |
| Central Themes | |
| Central Dogma of Molecular Biology | |
| Cell Biology Review | |
| The Animal Cell | |
| The Plant Cell | |
| Selected Organelles | |
| The Cell Cycle: Mitotic Cell Division | |
| Viruses | ... MORE |
| Chemistry Review | |
| Organic Compounds | |
| Chirality | |
| Chemical Reactions | |
| Physical Chemistry Concepts | |
| Buffering of Blood: The Bicarbonate System | |
| Amino Acids | |
| Basic Structures | |
| Amino acid 'R Groups' | |
| Ionization Properties | |
| Drawing Peptide Titration Plots | |
| Factors That Influence the pKa of Protonatable/Deprotonatable Groups in Proteins | |
| Proteins | |
| Peptide Bonds | |
| Purification and Characterization of Proteins | |
| Protein Structure | |
| Conformation | |
| Classification of Substructure | |
| Alpha (?) Helices | |
| Beta Sheets | |
| U-Turns | |
| Ramachandran Plot | |
| Stabilizing Factors | |
| Thermodynamics of Protein Folding: The Hydrophobic Effect | |
| Temperature-Dependant Denaturation | |
| Chaotropes and The Hofmeister Series | |
| Sodium Dodecyl Sulfate (SDS): Chaotrope Action | |
| Visualizing the Energy Landscape | |
| Protein Maturation | |
| Ligand Binding and Functional Control | |
| Oxygen Transport in Blood | |
| Hemoglobin Oxygen Binding: Cooperativity | |
| Antibodies: Immunological Recognition | |
| Enzymes | |
| Enzymes are Biological Catalysts | |
| Enzyme Function: Activity Assays and Enzyme Kinetics | |
| Requirements for Catalysis | |
| Comparing Enzymes and Relative Efficiency of Use of Substrates | |
| Drug Design | |
| Enzyme Inhibitors | |
| Allosterism | |
| Phosphorylation and Dephosphorylation | |
| Metabolic Enzyme Action | |
| Enzyme Mechanisms | |
| Modes of Catalysis | |
| The Reaction Coordinate | |
| Induced Fit Revisited | |
| Acid-Base Catalysis | |
| Covalent Group Transfer | |
| The Serine Protease Catalytic Triad Mechanism | |
| The Active Site of Tyrosyl-t | |
| RNA Synthetase | |
| Coenzymes | |
| Classification | |
| Survey of the Coenzymes | |
| 3 Metals | |
| Carbohydrates-Based Cofactors | |
| Fat Soluble Vitamins | |
| Carbohydrates and Glycoconjugates | |
| Carbohydrates: Definition | |
| Monosaccharides: Aldoses | |
| Monosaccharides: Ketoses | |
| Structural Features | |
| Intramolecular Cyclization | |
| Conformations: Sugar Puckers | |
| Sugar Derivatives | |
| Disaccharides | |
| Polysaccharides | |
| Carbohydrate-Protein Conjugates | |
| Synthesis and Structural Characterization | |
| Lipids | |
| Structural Overview | |
| Saturated and Unsaturated Fatty Acids | |
| Functions | |
| Diacylglycerol Lipid Derivatives | |
| Structural Motifs | |
| Assembly | |
| Structural and Dynamic Characterization | |
| Eicosanoids | |
| Phospholipases | |
| Phosphoinositides | |
| Steroids | |
| A Potpourri of Lipids | |
| Membranes | |
| The Fluid Mosaic Model | |
| Detergents | |
| Distribution of Lipids in Biological Membranes | |
| The Hydropathicity Scale | |
| Lipid-Anchored Membrane Proteins | |
| The Erythrocyte Cytoskeleton | |
| Transport Through Membranes | |
| The Transmembrane Potential | |
| Active Transport | |
| Ionophores | |
| The Acetylcholine Receptor Ion Channel | |
| Lactose Permease and Secondary Active Transport | |
| Mechanism of Transport by Na+, K+ ATPase | |
| Ion Channel Blockers | |
| Signal Transduction | |
| Signaling Pathways: Hormones, GTPases, Second Messengers and Intracellular Regulation | |
| The Adenylate Cyclase Signaling Pathway | |
| The Inositol-Phospholipid Signaling Pathway | |
| Phorbol Myristyl Acetate | |
| The Insulin Receptor | |
| Glucagon | |
| G-Proteins | |
| Nucleic Acids: DNA | |
| DNA and RNA | |
| Physical Properties | |
| Secondary Structure | |
| Backbone Structure | |
| Counterions | |
| Chemical Synthesis | |
| Watson-Crick Base Pairs | |
| Structural Modifications | |
| Three-Dimensional Structures | |
| Recognition of Sequences | |
| Genetic Mutations and Antisense Nucleic Acids | |
| Unusual DNA | |
| Stabilization of Nucleic Acids | |
| Secondary Structure Predictions | |
| Chromosomes | |
| Some Protein Nucleic Acid Binding Motifs | |
| Recombination | |
| RNA | |
| Cells Contain a Variety of Types of RNA | |
| RNAs Have Stable Secondary Structure | |
| Tertiary Structure: Transfer RNA | |
| Messenger RNA (mRNA) | |
| Eukaryotic Messenger RNA | |
| Alkaline Hydrolysis of RNA | |
| Small Interfering RNA | |
| Biotechnology | |
| Restriction Endonucleases | |
| Cloning in a Nutshell | |
| DNA Preparation: Phenol-Chloroform Extraction | |
| Polymerase Chain Reaction | |
| Probe DNA | |
| Metabolism | |
| Overview | |
| Metabolic Pathway Types | |
| Energy Conservation | |
| Key Pathways/Reactions | |
| Bioenergetics | |
| Reaction Equilibria: Standard and Actual Free Energies | |
| Metabolically Irreversible and Near Equilibrium Reactions | |
| Energies and Regulation of Glycolysis | |
| Bioelectrochemistry | |
| Redox Reaction Principles | |
| Redox Energetics: The Nernst Equation | |
| Electron Transport Chains | |
| Glycolysis | |
| Reactions 1 Through | |
| Regulation: Activation and Inhibition | |
| Four Fates of Pyruvate | |
| The Krebs Cycle | |
| Pathway | |
| Reactions | |
| Yields | |
| Cellular Redox Potential | |
| Regulation | |
| Gluconeogenesis | |
| Reactions | |
| Regulation | |
| Sources Used to Produce Glucose | |
| Electron Transport and Oxidative Phosphorylation | |
| Mitochondria in Red and White Muscle | |
| Overall Process | |
| Chemical and Potential Energies That Drive Proton Transport | |
| Mitochondrial Electron Transport | |
| Electron Transfer and Proton Flow in Complexes I through IV | |
| Oxidative Phosphorylation | |
| The Malate-Aspartate Shuttle and Proteomics | |
| Getting NADH Into the Mitochondrion: Isozymes | |
| Isozymes and Proteomics | |
| Characterization by Two-dimensional Gel Electrophoresis | |
| Mass Spectrometry and Proteomics | |
| Degradation and Synthesis of Lipids | |
| Beta Oxidation of Saturated Fatty Acids | |
| Biosynthesis of Fatty Acids | |
| Length Determination of Fatty Acids | |
| Synthesis of Acidic Phospholipids | |
| Cholesterol Biosynthesis | |
| Regulating Cholesterol Levels | |
| Photosynthesis | |
| Light and Dark Reactions | |
| Photo-Gathering Pigments | |
| Photosynthetic Electron Transport Pathway (Z scheme) | |
| The Calvin Cycle | |
| The Dark Reactions: Carbon Fixation | |
| Biosynthesis of Ribose-5-phosphate | |
| RuBis CO Mechanism | |
| The C4 and CAM Pathways | |
| The Urea Cycle | |
| Purpose and Reactions | |
| Regulation | |
| Comparative Nitrogen Excretion | |
| Protein Degradation and Programmed Cell Death | |
| Study Guide | |
| Review Session for Chapters 1 û 3 | |
| Review Session for Chapter 4 | |
| Review Session for Chapters 5 and 6 | |
| Review Session for Chapters 7 - 8.6 | |
| Review Sessions for Chapters 8.7 - 8.8 | |
| Review Session for Chapter 9 | |
| Review Session for Chapters 10 - 11.4 | |
| Review Session for Chapters 10 - 11.4: Key | |
| Review Session for Chapters 11.5 - 12.5 | |
| Review Session for Chapters 11.5 - 12.5: Key | |
| Review Session for Chapters 13 - 14.7 | |
| Review Session for Chapters 13 - 14.7: Key | |
| Review Session for Chapters 16.2 - 17.6 | |
| Review Session for Chapters 16.2 - 17.6: Key | |
| Review Session for Chapters 19 û 20 | |
| Table of Contents provided by Publisher. All Rights Reserved. |
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