9783527324897

This second edition of the pioneering work on this hot topic captures the major trends and latest achievements in the art of asymmetric catalysis on an industrial scale. A number of completely new real-life case studies written by the world leaders in their respective areas provide a compact and qualified insight into this developing field. The resulting ready reference and handbook collates first-hand and valuable information within a context where it can be easily found. The high-quality contributions illustrate the relevant environments and situations, such as time pressure, how the catalytic step fits into the overall synthesis, or competition with other synthetic approaches, as well as the typical problems encountered in the various phases, including finding/developing the catalyst and optimization of the process or choice of equipment. Both successful and unsuccessful approaches to solve these problems are described.

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Hans-Ulrich Blaser carried out his doctoral research with A. Eschenmoser at the Federal Institute of Technology (ETH) Z?rich, where he received the Ph.D. degree in 1971. Between 1971 and 1975 he held postdoctoral positions at the University of Chicago (J. Halpern), Harvard University (J.A. Osborn), and Monsanto (Z?rich). During 20 years at Ciba-Geigy (1976-1996) he gained practical experience at R&D in the fine chemicals and pharmaceutical industry, which continued at Novartis (1996-1999) and at Solvias where he presently is chief technology officer.

Hans-J?rgen Federsel is a renowned specialist in the field of process R&D with a professional career spanning over 30 years. Starting off as bench chemist in Astra at the major Swedish site in S?dert?lje, he climbed the ranks to occupy positions both as line and project manager. After the merger that formed AstraZeneca, he became Head of Projects Management at the aforementioned location and was then appointed to the newly created role as Director of Science in Global Process R&D in 2004. In connection with this, he was also given the prestigious title Senior Principal Scienstist. His strong academic links have been further developed over the years after obtaining the PhD in Organic Chemistry at the Royal Institute of Technology in Stockholm, which was led to his being awarded an Associate Professorship there.
His long-lasting links to this Institute has brought him a seat on the Board of the School of Chemical Science and Engineering from 2005. Publishing in peer reviewed journals and books and frequent lecturing has rendered fame to his name that goes far beyond the limits of the own company and Dr. Federsel enjoys invitations from all over the world to share learning and experience from his broad knowledge base on process R&D. In 2009 he was elected to the Royal Swedish Academy of Engineering Sciences (IVA).

Chemoenzymatic Route to the Side Chain of Rosuvastatin
Application of Multiple Enzyme Systems for Chiral Alcohols Production
Whole Microbial Cell Process for Manufacturing Amino Acids, Dipeptides and Oligosaccharides by Enzyme Catalysts Coupling with Cofactor Regeneration
Biocatalytic Routes to the Large Scale Synthesis of Lotrafiban
Asymmetric Oxidation for the Production of Bicyclic Proline Peptidomimetics
Enzymatic C-C Bond Formation
Large-Scale Applications of Hydrolases in Biocatalytic Asymmetric Synthesis
Enzymatic Two Step Approach Towards a Chiral Intermediate on Pilot Scale for a Coagulation Factor Xa Inhibitor
An Efficient, Asymmetric Synthesis of Odanacatib, a Selective Inhibitor of Cathepsin K for the Treatment of Osteoporosis, Using an Enzyme Mediated Dynamic Kinetic Resolution
The Discovery and Implementation of a Novel Catalytic Asymmetric Conjugate Addition Reaction in the Synthesis of Endothelin A Antagonist ABT-546
Scale-Up Studies in Asymmetric Transfer Hydrogenation
Ru-(Phosphine-Oxazoline) Complexes as Effective, Industrially Viable Catalysts for the Enantioselective Hydrogenation of Aryl Ketones
Chiral Lactones by Asymmetric Hydrogenation -
A Step Forward in (+)- Biotin Production
The Asymmetric Hydrogenation of an Alpha-Isopropyl-Cinnamic Acid, an Intermediate for the Blood-Pressure Lowering Drug Aliskiren
Commercialization of the Maruoka Catalyst
Development of Efficient Technical Processes for the Production of Enantiopure Amino Alcohols in Pharmaceutical Industry
The Kagan Oxidation -
Industrial Scale Asymmetric Sulfoxidations in the Synthesis of Two Related NK1/NK2 Antagonists
The Asymmetric Hydrogenation of Enones
Large Scale Application of Asymmetric Phase Transfer Catalysis for Amino Acid Synthesis
Crossing Over Hurdles in Large Scale Asymmetric Hydrogenation
Application of Phase Transfer Catalysis in the Asymmetric Synthesis of an Estrogen Receptor Beta Selective Agonist
Rh/Josiphos Catalyzed Ring Opening of Oxabicycles
Hydrogenations on Multi kg Scale
2,2',5,5'-Tetramethyl-4,4'-bis(diphenylphosphino)-3,3'-bithiophene: A not well Known but very Efficient Chiral Ligand for Ru Catalyzed Asymmetric Hydrogenations on Multi-Kilos Scale
3+2 Addition Reaction and Diastereosel Reduction f Imine Both on Multi 10 kg Scale
Enantioselective Hydrogenation: Applications in Process R&D of Pharmaceuticals
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Asymmetric Catalysis on Industrial Scale Challenges, Approaches and Solutions

Asymmetric Catalysis on Industrial Scale Challenges, Approaches and Solutions

3527324895

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