Attaining professional success and finding personal happiness in academic medicine is not an easy path, yet both are critical if the future is to be brighter because of better science, better clinical care, better training, better responsiveness to communities, and better stewards and leaders in the health professions. This book is intended as a resource to assist early- and middle-career physicians, clinicians, and scientists to understand the unique mission of academic medicine and to build creative, effective, and inspiring careers in academic health organizations.