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Emphasizing synthetic strategy and practice, Stereoselective Synthesis of Drugs and Natural Products features experimental procedures for stereoselective synthetic reactions applicable to drug targets and natural products. Compiling material from leading contributors into one cohesive resource, this practical resource on synthetic methodology, reaction mechanisms, and applications for medicinal chemistry and drug discovery explores strategy and interdisciplinary work, laboratory synthesis for natural products, the preparative aspects of stereoselective synthesis for drugs, natural products, and potential biologically active compounds. The text also features experimental procedures for the different reaction methods covered.
Table of Contents
List of contributors
List of symbols and abbreviations
PART 1: GENERAL METHODS AND STRATEGIES
Chapter 1: Principles, concepts and strategies of stereoselective synthesis Vasyl Andrushko and Natalia Andrushko
Chapter 2: Chiral auxiliaries in drug synthesis Stanley Chang, Shira D. Halperin, Jarod Moore and Robert Britton
Chapter 3: Solid-phase organic synthesis of drugs and natural products Peter J. H. Scott