His first two novels, Dangling Man (1944) and The Victim (1947) are penetrating, Kafka-like psychological studies. In 1948 he was awarded a Guggenheim Fellowship and spent two years in Paris and traveling in Europe, where he began his picaresque novel The Adventures of Augie March, which went on to win the National Book Award for fiction in 1954. His later books of fiction include Seize the Day (1956); Henderson the Rain King (1959); Mosby's Memoirs and Other Stories (1968); Mr. Sammler's Planet (1970); Humboldt's Gift (1975), which won the Pulitzer Prize; The Dean's December (1982); More Die of Heartbreak (1987); Theft (1988); The Bellarosa Connection (1989); The Actual (1996); Ravelstein (2000); and, most recently, Collected Stories (2001). Bellow has also produced a prolific amount of non-fiction, collected in To Jerusalem and Back, a personal and literary record of his sojourn in Israel during several months in 1975, and It All Adds Up, a collection of memoirs and essays.

Bellow's many awards include the International Literary Prize for Herzog, for which he became the first American to receive the prize; the Croix de Chevalier des Arts et Lettres, the highest literary distinction awarded by France to non-citizens; the B'nai B'rith Jewish Heritage Award for "excellence in Jewish Literature"; and America's Democratic Legacy Award of the Anti-Defamation League of B'nai B'rith, the first time this award has been made to a literary personage. In 1976 Bellow was awarded the Nobel Prize for Literature "for the human understanding and subtle analysis of contemporary culture that are combined in his work."

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