Designed for Learning. Grounded in Science. Built for Practice.

This comprehensive, first-edition text, developed specifically for advanced practice education, explores the cellular and molecular mechanisms of disease, organ-specific pathologies, and multisystem disorders with an emphasis on evidence-based application.

Students learn pathophysiology while simultaneously connecting it to related key concepts in pharmacology and assessment, enabling them to grasp not only what is happening in the body, but also how it intersects with the "3P" cornerstones of clinical decision-making. This approach reinforces the interconnected nature of advanced practice knowledge and better prepares students to deliver optimal real-world patient care.

• "Assessment Connection" and "Pharmacology Connection" boxes link pathophysiology, pharmacology, and assessment concepts, helping students to tie together the 3Ps and understand how their integration supports precise, informed clinical decisions. 
• “Learning Outcomes” are consistent with the relevant domains and outcomes advocated by the National Organization of Nurse Practitioner Faculty (NONPF) and Collegiate Commission on Nursing Education (CCNE) for competency-based graduate education.
• Clinical exemplars address how, where, and most importantly, why foundational concepts apply to clinical practice.
• "Clinical Connection" boxes inform how a pathophysiologic concept or process relates to clinical practice, including diagnostic reasoning and selection of management strategies. 
• "Patho Point" and "Physio Point" boxes highlight important high-yield facts/ /
• "Pediatric Point" and "Gero Point" boxes identify key clinical considerations for populations across the lifespan. 
• "Social Determinants of Health" boxes identify economic or other disparities that might impact access to or delivery of care. 
• "Genetic/Genomic Point" boxes articulate how a specific genetic alteration or identified pattern of inheritance influences a diagnosis.
• "Zebra" lists detail unusual or rare conditions diagnosed and managed by specialists, but that the primary care practitioner should be aware of as a collaborator in clinical care. 
• "So, Why?/So You Know" boxes explain complicated concepts using easy-to-grasp analogies or clinical application examples. 

PART I: FOUNDATIONAL PHYSIOLOGIC CONCEPTS
Unit I The Cell
Chapter 1.Cellular Biology, Regulation, and Control Mechanisms
Chapter 2.Cellular and Tissue Physiology
Chapter 3.Bioenergetics and Body Metabolism
Chapter 4.Body Fluid Homeostasis
Unit II Genetics and Genomics
Chapter 5.Basic Genetics
Chapter 6.Patterns of Inheritance, Mitochondrial Inheritance, Epigenetics, and Selected Associated Disorders
Unit III Inflammation, Immunity, Infection, and Cancer Biology
Chapter 7.Innate Immunity and Inflammation
Chapter 8. Adaptive Immunity
Chapter 9.Infectious Processes and Body Responses
Chapter 10.Abnormal Cell Growth and Cancer Biology

PART II: PATHOPHYSIOLOGY OF DISORDERS WITHIN SPECIFIC BODY SYSTEMS
OXYGENATION AND PERFUSION
Unit IVCardiovascular System
Chapter 11.Review of Cardiovascular Development, Structure, and Function
Chapter 12.Vascular Disorders
Chapter 13.Cardiac Disorders
Chapter 14.Congenital Heart Disease Across the Lifespan
Chapter 15.Shock and Multiple Organ Dysfunction Syndrome
Unit VPulmonary System
Chapter 16.Review of Pulmonary Structure, Development, and Function
Chapter 17.Congenital, Obstructive, and Restrictive Pulmonary Disorders
Chapter 18.Infectious Pulmonary Disorders and Lung Cancer
Unit VIRenal-Urinary System
Chapter 19.Review of Renal System Structure, Development, and Function
Chapter 20.Urinary Tract Disorders
Chapter 21. Kidney Disorders
Unit VIIHematologic and Lymphatic System
Chapter 22.Review of Hematologic System Development, Structure, and Function
Chapter 23.Hematologic and Lymphatic System Disorders
SENSATION, MOBILITY, AND REGULATION
Unit VIIINervous System
Chapter 24.Review of Nervous System Development, Structure, and Function
Chapter 25.Central Nervous System Disorders
Chapter 26.Peripheral Nervous System Disorders
Chapter 27.Disorders of the Special Senses
Chapter 28.Mental Health Disorders
Unit IXMusculoskeletal System
Chapter 29.Review of Musculoskeletal Development, Structure, and Function
Chapter 30.Muscle and Tendon Disorders
Chapter 31.Bone and Joint Disorders
Unit XEndocrine System
Chapter 32.Review of Endocrine Structure, Function, and Interactions
Chapter 33.Disorders of the Hypothalamus, Pituitary Glands, and Adrenal Glands
Chapter 34.Disorders of the Thyroid Gland and the Parathyroid Glands
Chapter 35.Glycemic Control and Diabetes Mellitus
PROTECTION, NUTRITION, AND REPRODUCTION
Unit XIDisorders of Immunity
Chapter 36.Disorders of Reduced Immune Function
Chapter 37.Hypersensitivity and Autoimmune Disorders
Unit XIIIntegumentary System
Chapter 38.Review of Integumentary Development, Structure, and Function
Chapter 39.Integumentary System Disorders
Unit XIIIDigestive System
Chapter 40.Review of Gastrointestinal Development, Structure, and Function
Chapter 41.Disorders of the Mouth, Throat, Esophagus, and Stomach
Chapter 42.Disorders of the Small Intestine, Large Intestine, Pancreas, and Hepatobiliary System
Unit XIV Reproductive Systems
Chapter 43.Review of Reproductive System Development, Structure, Function, and Sex Chromosome Abnormalities
Chapter 44.Common Disorders of the Female Reproductive System
Chapter 45.Male Reproductive Disorders
Chapter 46.Sexually Transmitted Infections
Chapter 47.Physiology and Pathophysiology of the Breast