9783527349081

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Presents a wide-ranging overview of essential topics and recent advances in MCR chemistry

Heterocycles are a central component in natural product chemistry, pharmaceuticals, agrochemicals, and material science. New synthetic methodologies integrating the sequencing of multicomponent reactions (MCRs) are today being used for the rapid synthesis of diversified heterocycles in just one step. Multicomponent Reactions towards Heterocycles presents an up-to-date summary MCR chemistry with a focus on the conjugation between modern synthetic methodologies and MCRs.

Featuring contributions by leaders in the field, this comprehensive resource highlights applications of MCRs in natural products and intermediate synthesis, discusses current trends and future prospects in MCR chemistry, outlines novel multicomponent procedures, and more. The authors provide the practical information required for designing new reaction strategies and mechanisms, covering topics including MCR-based green synthetic methods, cyclization and cycloaddition reactions, heterocycle multicomponent syntheses in a continuous flow, catalytic alkynoyl generation, MCR synthesis of saturated heterocycles, and C–H functionalization and multicomponent reactions.

Provides a thorough overview of heterocycles as input in multicomponent reactions
Discusses recent advances in the field of MCR chemistry and progress in the synthesis and functionalization of heterocycles
Demonstrates the use of MCRs to simplify synthetic design and achieve complexity and diversity in novel bioactive molecules
Highlights examples of multicomponent polymerizations, target-oriented synthesis, and applications of MCR in medicinal chemistry
Explains the methodology of using on-resin MCRs to produce heterocycle compounds

Illustrating the key role of MCRs towards heterocycles in natural product synthesis, drug discovery, organic synthesis, and other applications, Multicomponent Reactions towards Heterocycles is required reading for synthetic chemists in academia and industry alike.

Erik V. Van der Eycken is Full Professor Organic Chemistry and head of the Division Molecular Design & Synthesis, as well as head of the Laboratory for Organic & Microwave-Assisted Chemistry at the University of Leuven (KU Leuven), Belgium. The main focus of his research is the investigation of the application of microwave irradiation in different domains of organic synthesis, i.e. synthesis of bioactive natural product analogues and heterocyclic molecules applying transition metal-catalyzed reactions (i.a. homogeneous and heterogeneous (nanoparticles) gold catalysis), C-H activation, multicomponent reactions (MCRs), post-MCR modifications, and solid phase organic synthesis. Also Flow Chemistry and Photoredox Chemistry have been recently addressed. He is presently author of >290 scientific manuscripts in peer reviewed journals and books and has an H-index of 44. Until now 32 PhD-students performed their research under his guidance.

Dr. Upendra K. Sharma received his master degree from Guru Nanak Dev University in 2004 and his PhD degree (2011) in organic chemistry under the supervision of Dr. Arun K. Sinha at CSIR-Institute of Himalayan Bioresource Technology, Palampur, India. Thereafter, he worked as Assistant Professor at National Institute of Technology (NIT), Jalandhar, India. Later on, he joined the research group of Prof. Dr. Erik Van der Eycken, LOMAC, University of Leuven, Belgium as a postdoctoral fellow and until now has published more than 50 research articles in reputed international journals as well as co-edited a Springer series book on Flow Chemistry of Heterocycles. Recently, he has been permanently appointed as Research Expert in LOMAC, Department of Chemistry, KU Leuven. His research interests include the development of new synthetic methods for biologically relevant molecules employing modern methods of synthesis viz. flow chemistry, MCRs, photoredox catalysis and transition metal-catalyzed C-H functionalizations.

Recent Trends and Future Prospects of MCRs
MCRs Towards Target Oriented Synthesis of Biologically Relevant Heterocycles
Heterogeneous Approaches Towards Heterocycles via MCRs
Asymmetric Synthesis of Heterocycles in a Multicomponent Fashion
Solid-Phase MCRs Towards Heterocyclic Synthesis
Green Synthesis of Heterocycles via MCRs
Heterocycles via more than Four-Component Reactions
Multicomponent Flow-Chemistry Approaches Towards Heterocyclic Synthesis
Recent Trends on Metal-Catalyzed MCRs Towards Heterocycles
C-H Functionalization as an Imperative Tool Towards Multicomponent Synthesis and Functionalization of Heterocycles
Heterocyclic Syntheses via Novel MCRs
A Recent Update on Isocyanides Based MCRs Towards Heterocycles
Applied/Industrial MCR Approaches Towards Drugs and Intermediates
Alkyne and Allene Activation as an Entry to Mutlicomponent Syntheses of Heterocycles
Multicomponent Reaction and Total Synthesis

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Multicomponent Reactions towards Heterocycles Concepts and Applications

Multicomponent Reactions towards Heterocycles Concepts and Applications

3527349081

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