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Pathophysiology of Metabolic Syndrome: The Role of Essential Fatty Acids provides current research exploring the links among insulin, insulin receptors, polyunsaturated fatty acids, brain growth and disease. Specific interactions of essential fatty acids and polyunsaturated fatty acids in brain development and several disease groups are described. The role of inflammation in disease and how fatty acids regulate low-systemic inflammation are examined and explained. Metabolic and neurogenic dynamics are presented to provide a linkage between the presence of omega-3 and omega-6 and protection against diseases and conditions such as diabetes, obesity, autoimmune disease and hypertension.
Undurti N. Das, M.D. is the Chairman and Research Director of UND Life Sciences, USA and Ramalingaswami Fellow of the Department of Biotechnology, India. Dr Das is also the Editor-in-Chief of the journal Lipids in Health and Disease. He has published more than 400 international publications and has been awarded four USA patents.
Table of Contents
History, definition and diagnosis of the metabolic Syndrome
Insulin resistance in the metabolic syndrome
Is it necessary to redefine the metabolic syndrome?
Is insulin resistance a disorder of the brain?
Perinatal nutrition and obesity
Dietary factors and hypertension
Is hypertension a disorder of the brain?
Type 2 diabetes mellitus
Pathophysiology of type 2 diabetes mellitus with particular reference to hypothalamus
Insulin and insulin receptors in the brain and their role in the pathogenesis of obesity and type 2 diabetes mellitus
Insulin, endothelial nitric oxide and the metabolic syndrome
Obesity, type 2 diabetes mellitus and the metabolic syndrome and the gut microbiota
Is it possible that the metabolic syndrome originates in the perinatal period?
Essential fatty acids: biochemistry and Physiology
Role of EFAs/PUFAs in brain growth and development and pathophysiology of the metabolic syndrome
EFAs/PUFAs and their metabolites in insulin resistance
EFAs/PUFAs and atherosclerosis
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