JECKO THACHIL, MBBS, MD, MRCP, FRCPath is a consultant haematologist at Department of Haematology, Manchester Royal Infirmary in Manchester, UK. He has a special clinical interest in blood coagulation disorders and the prevention and treatment of venous thrombosis. He is the editor of the Wiley-Blackwell publication Haematology in Critical Care.

CATHERINE BAGOT, BSc, MBBS, MD, MRCP, FRCPath is a consultant haematologist at Department of Haematology, Glasgow Royal Infirmary in Glasgow, UK. He specializes in haemostasis and thrombosis at Glasgow Royal Infirmary and who is mainly interested in the role of thrombin generation in thrombosis risk stratification.

List of Contributors viii

Foreword xi

Section I Clinical Overview 1

1 Risk Factors for Venous Thromboembolism 3
Peter E. Rose

2 Management of Venous Thrombosis in the Lower Limbs 13
Dan Horner

3 Clinical Presentation of Acute Pulmonary Embolism 21
C.E.A. Dronkers, M.V. Huisman and F.A. Klok

Section II Diagnosis 27

4 Clinical Prediction Scores 29
Kerstin de Wit and Lana A. Castellucci

5 Laboratory Aspects in Diagnosis and Management of Venous Thromboembolism 35
Giuseppe Lippi and Emmanuel J. Favaloro

6 Thrombophilia Testing 49
Massimo Franchini

7 Radiological Diagnosis of Pulmonary Embolism 55
Joachim E. Wildberger and Marco Das

8 The Antiphospholipid Syndrome 60
Karen Breen

Section III Treatment 67

9 Inpatient or Outpatient Anticoagulation 69
Lauren Floyd and Jecko Thachil

10 An Anticoagulant Service in Practice 73
Kathy Macintosh, Dawn Kyle and Linda Smith

11 Point of Care Testing 86
Dianne Patricia Kitchen

12 Direct Oral Anticoagulants in the Prevention and Management of Venous Thromboembolism 94
Yen]Lin Chee and Henry G. Watson

13 The Role of Thrombolysis in the Management of Venous Thromboembolism 102
Carlos J. Guevara and Suresh Vedantham

14 Inferior Vena Cava Filters in the Management of Venous Thromboembolism 114
Anita Rajasekhar and Molly W. Mandernach

Section IV Special Situations 129

15 VTE in Pregnancy 131
Catherine Nelson Piercy

16 Paediatric Venous Thromboembolism 145
Paul Monagle and Rebecca Barton

17 Cancer]associated Thrombosis 153
Simon Noble

18 Venous Thromboembolism Management in Obese Patients 161
Kathryn Lang and Jignesh Patel

19 Venous Thromboembolism in Intensive Care 169
Gill Parmilan and Jecko Thachil

20 Venous Thromboembolism; a Primary Care Perspective 174
David Fitzmaurice

Section V Unusual Site Thrombosis 181

21 Cerebral Venous Thrombosis 183
Christian Weimar

22 Upper Extremity Thrombosis 192
Scott M. Stevens and Scott C. Woller

23 Management of Intra]abdominal Thrombosis 205
Serena M. Passamonti, Francesca Gianniello and Ida Martinelli

24 Thrombosis in the Retinal Circulation 216
Wenlan Zhang and Paul Hahn

Section VI Long]term Sequelae of VTE 229

25 Post]thrombotic Syndrome 231
Andrew Busuttil and Alun H. Davies

26 Chronic Thromboembolic Pulmonary Hypertension 240
Demosthenes G. Papamatheakis and William R. Auger

27 Predicting Recurrent VTE 255
R. Campbell Tait

Section VII Controversies 263

28 Cancer Screening in Unprovoked Venous Thromboembolism 265
David Keeling

29 Sub]segmental and Incidental PE – to Treat or Not? 269
Jecko Thachil

30 Management of Distal Vein Thrombosis 273
Giuseppe Camporese and Enrico Bernardi

Section VIII Prevention 281

31 A Summary of the Evidence for VTE Prevention, with a Focus on the Controversies 283
Catherine Bagot

32 VTE Prevention: Real World Practice 293
Emma Gee

33 VTE Root Cause Analysis – How To Do It 301
Alison Moughton, Francesca Jones and Will Lester

Index

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