Together, Catwoman, Harley Quinn and Poison Ivy are three of Gotham City's most powerful quasi-reformed criminals and together they spark scandal wherever they go.
 
Poison Ivy has long charmed the men of Gotham City, but now she's the one falling under a spell. Captivated with a plant-based alien inside S.T.A.R. Labs, she weds her cause to his and undertakes a Plantifest Destiny that leaves no room for humans—not even her sisters-in-crime. Catwoman and Harley Quinn try to tear their friend's heart away from the alien menace, but they find out how slowly the threat of love dies.
 
The excitement continues when an underworld plot to kidnap Catwoman and pluck her beloved Batman's identity from her mind shakes the Sirens. As the sorry enemy of Ivy and Harley' ex the Joker, the Dark Knight will always divide the three, and Catwoman's feelings have barely been tolerated to this point. So when Talia al Ghul and Zatanna rush in to help save Selina, it's not exactly clear who's doing the saving…and who's doing the hurting.
 
And when Harley stages a riot in Arkham Asylum to the Joker, it could be the beginning of the end of the Gotham City Sirens. As the situation inside Gotham quickly spins out of control, and Harley becomes more and more mired in her obsession with the Clown Prince of Crime, Poison Ivy and Catwoman struggle over how to handle their estranged teammate. The Gotham City Sirens are ready to make their final stand, but will they be fighting each other?
 
Writers Tony Bedard (SUPERGIRL) and television's Peter Calloway (Brothers & Sisters, Hellcats) team up with artists Andres Guinaldo (NIGHTWING), Jeremy Haun (BATWOMAN), Ramon F. Bachs (BATMAN: STREETS OF GOTHAM) and more, in GOTHAM CITY SIRENS BOOK TWO! Collects issues #14-26.