A complete reference for fermentation engineers engaged in commercial chemical and pharmaceutical production, the emphasis in the 'Fermentation & Biochemical Engineering Handbook' is on the operation, development and design of manufacturing processes which use fermentation, separation and purification techniques. Contributing authors from companies such as Merck, Eli Lilly, Amgen and Bristol-Myers Squibb highlight the practical aspects of the processes - data collection, scale-up parameters, equipment selection, troubleshooting, etc. and provide relevant perspectives for the different industry sectors utilizing fermentation techniques: chemical, pharmaceutical, food, biofuels, etc. New sections on topics relevant to modern recombinant cell fermentation, mammalian cell culture and biorefinery ensure that the book remains applicable around the globe and uniquely demonstrates the relationships between the synthetic processes for small molecules such as active ingredients, drugs and chemicals and the biotechnology of protein, vaccine, hormone and antibiotic production. The third edition is a major revision of this key handbook, and also includes new material on membrane pervaporation technologies for biofuels and nanofiltration, and recent developments in instrumentation such as optical-based dissolved oxygen probes, capacitance-based culture viability probes and in situ real-time fermentation monitoring with wireless (radiowave) technology. Topical environmental considerations are addressed and the use of newer (bio)technologies to treat and utilize waste streams, produce renewable energy from wastewaters and options for Bioremediation are explained Fully updated to cover latest advances in recombinant cell fermentation, mammalian cell culture and biorefinery along with details of the most recent developments in instrumentation. Industrial contributors from leading global companies, eg. Merck, Eli Lilly, Amgen, Bristol Myers Squibb. Covers synthetic processes for both small and large molecules