The authors

Lesley A. Colby, DVM, MS, DACLAM, is an Associate Professor and Senior Director of Animal Resources and Operations in the Department of Comparative Medicine at the University of Washington in Seattle, Washington, USA.

Megan H. Nowland, DVM, DACLAM, is an Associate Professor in the Unit for Laboratory Animal Medicine at the University of Michigan in Ann Arbor, Michigan, USA.

Lucy H. Kennedy, DVM, DACLAM, is an Assistant Professor in the Unit for Laboratory Animal Medicine at the University of Michigan in Ann Arbor, Michigan, USA.

About the Authors xii

Preface xiii

About the Companion Website xiv

1 Introduction to Laboratory Animal Medicine 1

Animals Used in Research, Teaching, and Testing 2

Ethical Considerations 8

Organizations 12

Bibliography 17

Further Reading 18

Chapter 1 Review 19

2 Regulations, Policies, and Principles Governing the Care and Use of Laboratory Animals 22

Animal Welfare Act and Regulations 22

Public Health Service Policy on Humane Care and Use of Laboratory Animals 28

Other Regulations, Policies, Guidance Documents, and Organizations 31

References 36

Further Reading 37

Chapter 2 Review 37

3 Facility Design, Housing, Equipment, and Management 39

Laboratory Animal Facility Design 39

Common Facility Classifications 46

Housing 50

Facility Equipment 59

Management 66

Bibliography 69

Further Reading 69

Chapter 3 Review 71

4 Mice 74

Genetics 74

Microbiologic Classifications 76

Uses 77

Behavior 77

Anatomic and Physiologic Features 78

Breeding and Reproduction 80

Husbandry 81

Techniques 86

Special Techniques: Transgenic Production Technology 96

Therapeutic Agents 101

Introduction to Diseases of Mice 101

Viral Diseases 107

References 114

Further Reading 119

Chapter 4 Review 122

5 Rats 124

Genetics 124

Microbiologic Classifications 125

Uses 126

Behavior 126

Anatomic and Physiologic Features 127

Breeding and Reproduction 129

Husbandry 130

Techniques 133

Therapeutic Agents 143

Introduction to Diseases of Rats 144

Bibliography 157

Further Reading 162

Chapter 5 Review 162

6 Gerbils 165

Uses 165

Behavior 166

Anatomic and Physiologic Features 166

Breeding and Reproduction 167

Husbandry 168

Techniques 170

Therapeutic Agents 176

Introduction to Diseases of Gerbils 176

Bibliography 181

Further Reading 183

Chapter 6 Review 184

7 Hamsters 185

Uses 185

Behavior 186

Anatomic and Physiologic Features 187

Breeding and Reproduction 189

Husbandry 190

Techniques 192

Therapeutic Agents 198

Introduction to Diseases of Hamsters 198

Bibliography 207

Further Reading 209

Chapter 7 Review 210

8 Guinea Pigs 212

Uses 212

Behavior 213

Anatomic and Physiologic Features 214

Breeding and Reproduction 216

Husbandry 218

Techniques 219

Therapeutic Agents 225

Introduction to Diseases of Guinea Pigs 226

Bibliography 238

Further Reading 240

Chapter 8 Review 242

9 Chinchillas 243

Uses 243

Behavior 244

Anatomic and Physiologic Features 244

Breeding and Reproduction 246

Husbandry 247

Techniques 249

Therapeutic Agents 253

Introduction to Diseases of Chinchillas 255

Bibliography 260

Further Reading 262

Chapter 9 Review 262

10 Zebrafish 264

Uses 264

Behavior 265

Anatomic and Physiologic Features 265

Reproduction and Life Stages 266

Husbandry 268

Techniques 274

Therapeutic Agents 278

Introduction to Diseases of Zebrafish 278

Bibliography 283

Further Reading 284

Chapter 10 Review 285

11 Rabbits 286

Breeds 286

Uses 287

Behavior 288

Anatomic and Physiologic Features 288

Breeding and Reproduction 291

Husbandry 293

Techniques 297

Therapeutic Agents 308

Introduction to Diseases of Rabbits 309

Bibliography 326

Further Reading 329

Chapter 11 Review 331

12 Ferrets 333

Uses 333

Behavior 334

Anatomic and Physiologic Features 334

Breeding and Reproduction 336

Husbandry 337

Techniques 339

Therapeutic Agents 347

Introduction to Diseases of Ferrets 347

Bibliography 365

Further Reading 369

Chapter 12 Review 369

13 Primates 371

Taxonomy 371

Uses 375

Behavior 376

Anatomic and Physiologic Features 377

Breeding and Reproduction 378

Husbandry 380

Techniques 383

Therapeutic Agents 390

Introduction to Diseases of Nonhuman Primates 390

Bibliography 410

Further Reading 413

Chapter 13 Review 416

14 Cattle, Sheep, Goats, and Pigs 417

Uses 417

Behavior 418

Anatomic and Physiologic Features 419

Breeding and Reproduction 419

Husbandry 420

Techniques 424

Therapeutic Agents 428

Introduction to Diseases of Agricultural Animals of Particular Importance to Research 428

Bibliography 434

Further Reading 435

Chapter 14 Review 435

15 Research Variables, Biosecurity, and Colony Health Surveillance 437

Research Variables 437

Biosecurity and Exclusion of Contaminants 445

Animal Colony Health Surveillance 448

Bibliography 455

Further Reading 455

Chapter 15 Review 456

Appendix 1: Normal Values 459

Appendix 2: Comparative Biologic and Reproductive Values by Species 464

Answers to Review Questions 467

Index 474

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