Clinical Chemistry : Principles, Procedures, Correlations

ISBN 13:
9780781717762
ISBN 10:
0781717760
Format: Hardcover
Copyright: 11/01/1999
Publisher: Lippincott Williams & Wilkins
Newer Edition

Note: Not guaranteed to come with supplemental materials (access cards, study guides, lab manuals, CDs, etc.)

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Summary

Organon Teknika Corporation, Durham, NC. Textbook Brandon/Hill Allied Health List selection (#30). Completely revised text incorporates recent technologies, techniques, and opportunities. Balances analytical principles and techniques and the correlation of laboratory results. For students. Two-tone highlighting. Previous edition: c1996. DNLM: Chemistry, Clinical.

Part 1 Basic Principles and Practice of Clinical Chemistry

Basic Principles and Practice of Clinical Chemistry

Eileen Carreiro-Lewandowski

Units of Measure

(1)

Temperature

(1)

Reagent Preparation

(3)

Clinical Laboratory Supplies

(8)

Basic Separation Techniques

(1)

Laboratory Mathematics and Calculations

(7)

Specimen Considerations

(4)

Summary

(1)

Exercises

(1)

References

(1)

Laboratory Safety and Regulations

Carolyn Houghton

Mary Ruth Beckham

Laboratory Safety and Regulations

(1)

Safety Awareness for Clinical Laboratory Personnel

(1)

Safety Equipment

(2)

Biologic Safety

(1)

Chemical Safety

(2)

Radiation Safety

(1)

Fire Safety

(1)

Control of Other Hazards

(2)

Disposal of Hazardous Materials

(1)

Accident Documentation and Investigation

(1)

Summary

(1)

Review Questions

(1)

Suggested Readings

(1)

Quality Control and Statistics

George S. Cembrowski

Anne M. Sullivan

Tammy L. Hofer

Statistical Concepts

(7)

Reference Intervals (Normal Range)

(4)

Diagnostic Efficacy

(2)

Method Selection and Evaluation

(5)

Quality Assurance and Quality Control

(13)

Practice Problems

(2)

Review Questions

(1)

References

(3)

Analytical Techniques and Instrumentation

Alan H. B. Wu

Spectrophotometry and Photometry

(11)

Electrochemistry

(3)

Electrophoresis

(3)

Chromatography

(6)

Osmometry

100

(1)

Analytical Techniques for POCT

101

(1)

Summary

101

(1)

Exercises

102

(1)

References

103

(2)

Immunoassays and Nucleic Acid Probe Techniques

Catherine Sheehan

Immunoassays

105

(13)

Nucleic Acid Probes

118

(3)

Summary

121

(1)

Review Questions

121

(1)

References

122

(2)

Principles of Clinical Chemistry Automation

Larry Schoeff

History of Automated Analyzers

124

(1)

Driving Forces Toward More Automation

125

(1)

Basic Approaches to Automation

125

(1)

Steps in Automated Analysis

126

(11)

Selection of Automated Analyzers

137

(1)

Total Laboratory Automation

137

(2)

Future Trends in Automation

139

(1)

Summary

140

(1)

Review Questions

140

(1)

References

140

(2)

Point-of-Care Testing

Steve Bradley

Point-of-Care Testing (POCT)

142

(1)

Use and Applications for POCT

142

(2)

Implementation and Monitoring of POCT

144

(3)

Cost Issues

147

(1)

Regulatory Issues

148

(1)

Summary

148

(1)

Review Questions

149

(1)

References

149

(3)

Part 2 Clinical Correlations and Analytical Procedures

Amino Acids and Proteins

Barbara J. Lindsey

Amino Acids

152

(6)

Proteins

158

(24)

Summary

182

(1)

Review Questions

182

(1)

References

183

(2)

Enzymes

Robin Gaynor Krefetz

General Properties and Definitions

185

(1)

Enzyme Classification and Nomenclature

186

(1)

Enzyme Kinetics

186

(6)

Enzymes of Clinical Significance

192

(16)

Pathophysiologic Conditions

208

(4)

Summary

212

(1)

Review Questions

213

(1)

References

213

(1)

Suggested Readings

214

(1)

Carbohydrates

Vicki S. Freeman

General Description of Carbohydrates

215

(5)

Hyperglycemia

220

(4)

Hypoglycemia

224

(2)

Role of Laboratory in Differential Diagnosis and Management of Patients With Glucose Metabolic Alterations

226

(4)

Summary

230

(1)

Review Questions

230

(1)

References

231

(2)

Lipids and Lipoproteins

Judith R. McNamara

G. Russell Warnick

Lily L. Wu

Lipid Chemistry

233

(4)

Lipoprotein Physiology and Metabolism

237

(4)

Lipid and Lipoprotein Analyses

241

(7)

Lipid and Lipoprotein Distribution in the Population

248

(2)

Disease Prevention, Diagnosis, and Treatment

250

(4)

Summary

254

(1)

References

255

(6)

Nonprotein Nitrogen

Dennis W. Jay

Urea

261

(2)

Creatinine/Creatine

263

(4)

Uric Acid

267

(3)

Ammonia

270

(2)

Summary

272

(1)

Review Questions

272

(1)

References

273

(2)

Porphyrins and Hemoglobin

Louann W. Lawrence

Porphyrins

275

(5)

Hemoglobin

280

(11)

Myoglobin

291

(1)

Summary

291

(1)

Review Questions

292

(1)

References

293

(1)

Electrolytes

Joan E. Polancic

Water

294

(3)

The Electrolytes

297

(21)

Anion Gap

318

(1)

Electrolytes and Renal Function

318

(2)

Summary

320

(1)

Review Questions

320

(1)

References

320

(2)

Trace Elements

Susan A. Hurgunow

Iron

322

(4)

Copper

326

(2)

Zinc

328

(1)

Cobalt

328

(1)

Chromium

328

(1)

Fluorine

328

(1)

Manganese

329

(1)

Molybdenum

329

(1)

Selenium

329

(1)

General Considerations in Laboratory Determinations of Trace Elements

330

(1)

Summary

330

(1)

Review Questions

330

(1)

References

331

(4)

Blood Gases, pH, and Buffer System

Sharon S. Ehrmeyer

Kevin D. Fallon

Definitions: Acid, Base, Buffer

335

(1)

Acid-Base Balance

335

(3)

Assessment of Acid-Base Homeostasis

338

(2)

Oxygen and Gas Exchange

340

(4)

Measurement

344

(3)

Quality Assurance

347

(3)

Summary

350

(1)

Review Questions

350

(1)

References

350

(4)

Part 3 Assessment of Organ System Functions

Liver Function

Edward P. Fody

Anatomy

354

(1)

Physiology

354

(4)

Disorders of the Liver

358

(1)

Assessment of Liver Function

359

(9)

Summary

368

(1)

Review Questions

368

(1)

References

369

(4)

Endocrinology

Shauna C. Anderson

Hormones

373

(2)

Methodologies

375

(3)

Components of the Endocrine System

378

(20)

Summary

398

(1)

Review Questions

399

(2)

References

401

(2)

Thyroid Function

H. Jesse Guiles

Thyroid Anatomy and Physiology

403

(1)

Biosynthesis, Secretion, Transport, and Action of Thyroid Hormones

404

(1)

Regulation of Thyroid Hormones

405

(1)

Assays for Thyroid Function

406

(3)

TSH

409

(4)

Thyroid Disorders and Correlation of Laboratory Data

413

(7)

Summary

420

(1)

Review Questions

420

(1)

References

420

(3)

Cardiac Function

Lynn Ingram

The Heart

423

(2)

Symptoms of Heart Disease

425

(1)

Congenital Heart Disease

425

(2)

Congestive Heart Failure

427

(2)

Coronary Heart Disease

429

(1)

Hypertensive Heart Disease

430

(1)

Infective Heart Disease

431

(1)

Diagnosis of Heart Disease

432

(4)

Treatment

436

(2)

Summary

438

(1)

Review Questions

438

(1)

References

439

(1)

Renal Function

Carol J. Skarzynski

Alan H. B. Wu

Renal Anatomy

440

(1)

Renal Physiology

441

(6)

Analytical Procedures

447

(6)

Pathophysiology

453

(8)

Summary

461

(1)

Review Questions

462

(1)

References

462

(1)

Pancreatic Function

Edward P. Fody

Physiology of Pancreatic Function

463

(1)

Diseases of the Pancreas

464

(2)

Tests of Pancreatic Function

466

(3)

Summary

469

(1)

Review Questions

469

(1)

References

470

(1)

Suggested Readings

470

(1)

Gastrointestinal Function

Edward P. Fody

Physiology and Biochemistry of Gastric Secretion

471

(1)

Clinical Aspects of Gastric Analysis

471

(1)

Tests of Gastric Function

472

(1)

Intestinal Physiology

472

(1)

Clinicopathologic Aspects of Intestinal Function

473

(1)

Tests of Intestinal Function

473

(2)

Summary

475

(1)

Review Questions

475

(1)

References

476

(1)

Suggested Readings

476

(1)

Body Fluid Analysis

Frank A. Sedor

Amniotic Fluid

477

(5)

Cerebrospinal Fluid

482

(3)

Sweat

485

(1)

Synovial Fluid

486

(1)

Serous Fluids

486

(1)

Summary

487

(1)

Review Questions

488

(1)

References

489

(1)

Suggested Readings

489

(3)

Part 4 Specialty Areas of Clinical Chemistry

Therapeutic Drug Monitoring

David P. Thorne

Routes of Administration

492

(1)

Absorption

492

(1)

Free Versus Bound Drugs

493

(1)

Drug Distribution

493

(1)

Drug Elimination

493

(2)

Pharmacokinetics

495

(2)

Sample Collection

497

(1)

Cardioactive Drugs

497

(2)

Antibiotics

499

(1)

Antiepileptic Drugs

500

(1)

Psychoactive Drugs

501

(1)

Bronchodilators

502

(1)

Immunosuppressive Drugs

502

(1)

Antineoplastics

503

(1)

Summary

503

(1)

Review Questions

504

(1)

References

505

(1)

Suggested Readings

505

(1)

Toxicology

David P. Thorne

Exposure to Toxins

506

(1)

Routes of Exposure

507

(1)

Dose Response Relationship

507

(1)

Analysis of Toxic Agents

508

(1)

Toxicology of Specific Agents

508

(7)

Toxicology of Therapeutic Drugs

515

(1)

Toxicology of Drugs of Abuse

516

(3)

Summary

519

(1)

Review Questions

519

(1)

References

520

(1)

Suggested Readings

521

(2)

Tumor Markers

Anthony W. Butch

Nicole A. Massoll

Alex A. Pappas

Classification of Tumor Markers

523

(1)

Tumor Markers in Cancer Management

523

(26)

Properties of an Ideal Tumor Marker

549

Oncofetal Antigens

524

(6)

Placental Proteins

530

(1)

Enzymes and Isoenzymes as Tumor Markers

531

(1)

Hormones

532

(1)

Steroid Receptors

533

(1)

Immunophenotyping

534

(1)

DNA Analyses

534

(2)

Summary and Future Developments

536

(1)

Review Questions

536

(1)

References

537

(3)

Vitamins and Nutritional Assessment

A. Michael Spiekerman

Vitamins

540

(14)

Nutritional Assessment

554

(12)

Summary

566

(1)

Review Questions

567

(1)

References

568

(4)

Clinical Chemistry and the Geriatric Patient

Janet L. Duben-Engelkirk

Sharon M. Miller

The Impact of Geriatric Patients on the Clinical Laboratory

572

(1)

Theories of Aging

573

(1)

Biochemical and Physiological Changes of Aging

574

(4)

Clinical Chemistry Results and Aging

578

(3)

Summary

581

(1)

Review Questions

581

(1)

References

581

(2)

Pediatric Clinical Chemistry

John E. Sherwin

Juan R. Sobenes

Age Related Development Changes

583

(1)

Phlebotomy and Microchemistry for the Pediatric Patient

584

(1)

Acid Base Balance in the Infant

584

(1)

Electrolyte and Water Balance

585

(3)

Energy Metabolism

588

(6)

Developmental Changes in Hormone Balance

594

(4)

Drug Therapy and Pharmacokinetics

598

(1)

Inborn Errors of Metabolism

598

(3)

Humoral and Cellular Immunity

601

(6)

Summary

607

(1)

Review Questions

607

(1)

References

608

(1)

Appendices

609

(18)

A. Selected Laboratory Abbreviations

610

(1)

B. Basic SI Units

611

(1)

C. Prefixes to be Used with SI Units

611

(1)

D. Basic Clinical Laboratory Conversions

611

(1)

E. Conversion of Traditional Units to SI Units for Common Chemistry Analytes

612

(1)

F. Greek Alphabet Table

613

(1)

G. Concentrations of Commonly Used Acids and Bases with Related Formulas

613

(1)

H. Examples of Incompatible Chemicals

614

(1)

I. Nomogram for the Determination of Body Surface Area

615

(1)

J. Relative Centrifugal Force Nomograph

616

(1)

K. Centrifugation---Speed and Time Adjustment

617

(1)

L. Percent Transmittance--Absorbance Conversion Table

617

(1)

M. Selected Atomic Weights

618

(1)

N. Selected Radioactive Elements

619

(1)

O. Characteristics of Types of Glass

619

(1)

P. Characteristics of Types of Plastic

620

(1)

Q. Chemical Resistance of Types of Plastic

620

(1)

R. Cleaning Labware

621

(1)

S. Summary Table of Pharmacokinetic Parameters

622

(2)

T. Selected Information on Commonly Abused Drugs

624

(2)

U. Periodic Chart of the Elements

626

(1)

Glossary

627

(12)

Answers to Review Questions, Exercises, Practice Problems, and Case Studies

639

(22)

Index

661

Clinical Chemistry : Principles, Procedures, Correlations

9780781717762

0781717760

Summary

Table of Contents

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Clinical Chemistry : Principles, Procedures, Correlations

9780781717762

0781717760

Summary

Table of Contents

Write a Review

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