The Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments. This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza viruses in the field of human and veterinary public health.

Textbook of Influenza examines the lessons learnt from the latest pandemic and provides the current state of knowledge for many yet unresolved issues related to virus origin, spread, pathogenesis and disease severity to better prepare for future pandemics. It covers the background to recent advances in influenza genomics and reverse genetics which have allowed the identification of virus virulence factors and the analysis and reconstruction of influenza viruses such as the 1918 Spanish flu strain.

This new edition is divided into eight key sections, containing chapters co-written by international experts from both the clinical and scientific communities, covering:
• Influenza Perspectives
• Structure and Replication
• Evolution and Ecology
• Epidemiology and Surveillance
• Immunology
• Vaccines and Vaccine Development
• Clinical Aspects and Antivirals
• Public Health

Textbook of Influenza is for all those working in the area of influenza including clinical and basic scientists, immunologists, molecular and structural virologists, public health officials and global pandemic control planners.

PART 1: Influenza-Perspective
Section Editor: Robert G. Webster

1 Human Influenza: One Health, One World
Daniel B. Jernigan and Nancy J. Cox

2 Influenza Pandemics: History and Lessons Learnt
Arnold S. Monto and Robert G. Webster

PART 2: Structure and Replication
Section Editor: Robert A. Lamb

3 Structure, Disassembly, Assembly and Budding of Influenza Viruses
Debiprosad Nayak, Sakar Shivakoti, Rilwan A. Balogun, Gwendolyn Lee and Z. Hong Zhou
 
4The Virus Gene and its Replication
Robert M. Krug and Ervin Fodor

5 Influenza Glycoproteins: Haemagglutinin and Neuraminidase
Rupert J. Russell, Steven J. Gambin and John J. Skehel

6 Proton Channels of Influenza A and B Viruses
Chunlong Ma, Lawrence H. Pinto and Robert A. Lamb

7 The NS1 Protein: A Master Regulator of Host and Viral Functions
Robert M. Krug and Adolfo García-Sastre

8 Structure and Function of the Influenza Virus Replication Machinery and PB1-F2
Andrew Mehle and Jonathan A. McCullers

9 The Genome and its Manipulation: Recovery of the 1918 Virus and Vaccine Virus Generation
Gabriele Neumann and Yoshihiro Kawaoka

10 Pathogenesis
Hans-Dieter Klenk

PART 3: Evolution and Ecology of Influenza Viruses
Section Editor: Robert. G. Webster

11 Ecology and evolution of influenza viruses in wild and domestic birds
Ron A. M. Fouchier and Yi Guan

12 Influenza in Swine
Richard Webby and Juergen A. Richt

13 Equine / Canine/ Feline / Seal Influenza
Thomas M. Chambers, Edward J. Dubovi, and Ruben O. Donis

14 Emergence and Evolution of the 1918, 1957, 1968, and 2009 Pandemic Virus Strains
Taia T. Wang and Peter Palese

PART 4: Epidemiology and Surveillance
Section Editor: Arnold S. Monto

15 Influenza Surveillance and Laboratory Diagnosis
Maria Zambon

16 Epidemiology of Influenza
Marc-Alain Widdowson and Arnold S. Monto

PART 5: Immunology of Influenza
Section Editor: Thomas J. Braciale

17 Innate Immunity
Akiko Iwasaki and Malik Peiris

18 Antibody-Mediated Immunity
Nicole Baumgarth, Michael C. Carroll and Santiago Gonzalez

19 Cell-mediated immunity
Stephen J. Turner, Peter C. Doherty and Anne Kelso

PART 6: Vaccines and Vaccine Development
Section Editors: Thomas J. Braciale and Arnold S. Monto

20 Immunogenicity, Efficacy of Inactivated/Live Virus Seasonal and Pandemic Vaccines
John Treanor, Wendy A. Keitel, Kathleen M. Neuzil

21 New Approaches to Medicine
Chih-Jen Wei, Damian C. Ekiert, Gary J. Nabel and Ian A. Wilson

22 Control of Influenza in Animals
Ilaria Capua and Dennis J. Alexander

23 Influenza Vaccine Production
Klaus Stöhr

PART 7: Clinical Aspects and Antivirals
Section Editors: Robert G. Webster and Arnold S. Monto

24 Human Influenza: Pathogenesis, Clinical Features, and Management
Federick G. Hayden and Menno D. de Jong

25 Antivirals: Targets and Use
Michael G. Ison and Alan Hay

26 The Control of Influenza and Cost Effectiveness of Interventions
Carolyn B. Bridges, Samuel K. Peasah and Martin I. Meltzer

27 Applications of Quantitative Modeling to Influenza Virus Transmission Dynamics, Antigenic and Genetic Evolution, and Molecular Structure
Marc Lipsitch and Derek Smith

28 Pandemic Preparedness and Response
Jonathan S. Nguyen-Van-Tam and Joseph Bresee

29 Influenza: The Future
Thomas J. Braciale