Stem Cell Therapeutics for Cancer covers the application of stem cells in various cancers, with an emphasis on the aspects of these strategies that are critical to the success of future stem cell-based therapies for cancer. Topics covered in the book include stem cell sources, tumor specificity, targeted therapeutics, visualizing the stem cell, and therapeutic agent pharmacokinetics. Each chapter contains a brief introduction to the cancer, followed by an exploration of how engineered stem cells have been utilized to cure the disease in mouse models and in early phase clinical trials.

• Comprises of sections on stem cell therapy in brain cancers, lung cancers, breast cancers, as well as stem cells in combination with other therapies
• Focuses on the practical applications of using stem cells as gene delivery agents to treat cancer
• Includes coverage of cutting-edge molecular imaging techniques in stem cell therapeutics for a variety of tumour types

SECTION 1: INTRODUCTION

Ch01   Different stem cell types and their potential for cancer therapeutics Angelo Vescovi and Khalid Shah

SECTION 2: MIGRATION AND FATE OF STEM CELLS

Ch02   2.1. Role of CXCR4 in tumoritropic migration of stem cells. Moneeb Ehtesham

Ch03   2.2. MMP-1 mediated tumoritrophic migration of stem cells. Paula Lam

SECTION 3: STEM CELL THERAPY IN BRAIN CANCER

Ch04   3.1.
Brain tumors and TRAIL mediated glioma therapy utilizing different stem cell types.

Khalid Shah

Ch05   3.2.
Stem Cells as Cellular Delivery Vehicles for Prodrug Gene Therapy of Glioblastoma.

Cestmir Altaner

Ch06   3.3. Role of naïve cord blood stem cells on glioma therapy
Venkata Ramesh Dasari,Kiran Kumar Velpula, Christopher S. Gondi, Jasti S. Rao

Ch07   3.4. Targeting brain tumor vasculature with engineered neural stem cells.

Navid Redjal and Khalid Shah

Ch08   3.5. Treatment of metastatic neuroblastoma with systemic oncolytic virotherapy delivered by autologous mesenchymal stem cells.

Manuel Ramirez and Javier Garcia-Castro

SECTION 4: STEM CELL THERAPY IN OTHER CANCER TYPES

Ch09   4.1. Umbilical cord matrix stem cells for cytotherapy of breast cancer

Naomi Ohta, Atsushi Kawabata, Deepthi Uppalapati, Susumu Ishiguro, Deryl Troyer,  Masaaki Tamura

Ch10   4.2. Mesenchymal stromal cells as effective tumor antigen-presenting cells in cancer therapeutics

Raphaëlle Romieu-Mourez and Jacques Galipeau

Ch11   4.3.Diagnostic and TherapeuticMesenchymal stem cell for breast cancer treatment

Dwyer Roisin 

Ch12   4.4. Genetically Engineered Stem Cell Therapies Targeting Gastrointestinal Malignancy

Emily Keung, Peter J. Nelson and Claudius Conrad

Ch13   4.5. Mesenchymal stem cells in prostate cancer: Clinical Opportunities.

Diptiman Chanda and Selvarangan Ponnazhagan

Ch14   4.6. Primed mesenchymal stromal cells for cancer therapy

Augusto Pessina, Arianna Bonomi, Eugenio Parati, Roberto Pallini and Giulio Alessandri

SECTION 5: COMBINATORIAL STEM CELL THERAPIES

Ch15   5.1. Therapeutic efficacy of the combination of targeting microRNAs and stem cell released therapeutics on  tumors.
Maarten Anderegg and Marten Corsten

Ch16   5.2. Therapeutic efficacy of PI3-Kinase inhibitors with stem cell delivered TRAIL therapy in tumors.

Tugba Bagci-Onder

Ch17   5.3. The efficacy of clinically approved agents with stem cell delivered therapeutics for cancer therapy.

Hiroaki Wakimoto and Khalid Shah

SECTION 6: TRACKING STEM CELLS AND STEM CELL BASED THERAPEUTICS

Ch18   6.1. Imaging migration and fate of stem cells in different tumor models.
Deepak Bhere and Khalid Shah

Ch19   6.2. Integrating therapeutic and diagnostic activities in stem cell expressing molecules to reveal multiple aspects of stem cell-based therapy.
Shawn Hingtgen

Ch20   6.3. Tracking cancer targeted MSC by PET imaging.
Véronique Roelants and Jean-Louis Vanoverschelde