Hossein Baharvand, PhD, is a Professor and Director of Royan Institute for Stem Cell Biology and Technology, Cell Science Research Center, ACECR, Tehran, Iran. Dr. Baharvand is also Head of the Department of Developmental Biology at the University of Science and Culture, ACECR, Tehran, Iran.

Nasser Aghdami, MD, PhD is an Associate Professor and Head of the Department of Regenerative Medicine at the Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Dr. Aghdami is also Head of Royan Cell Therapy Center, ACECR, Tehran, Iran.

About the Editors ix

Contributors xi

Preface xvii

Part 1 An Introduction to Stem Cells 1

1 Adult Stem Cells 3
Andreas Nussler and Sahar Olsadat Sajadian

2 Pluripotent Stem Cells 25
Hossein Azizi, Akbar Hajizadeh Moghaddam, and Thomas Skutella

3 Interactions of Stem Cells and Components of the Extracellular Matrix 35
Anna K. Blakney, Julie J. Antetomaso, Winnie W. Leung, and Deok-Ho Kim

4 Regenerative Medicine and Cell Therapy: Past, Present, and Future 47
Hooman Sadri-Ardekani and Anthony Atala

Part 2 An Introduction to Nanotechnology 67

5 Principles of Nanotechnology 69
Jerzy Leszczynski

6 Stem-Cell Nanoengineering: Explorations in a Rapidly Moving Field 87
Abhalaxmi Singh and Sanjeeb K. Sahoo

Part 3 Nanostructures for Stem-Cell Engineering – Engineering Approach 97

7 Nanopatterned Surfaces for Stem-Cell Engineering 99
Waleed Ahmed El-Said, Tae-Hyung Kim, Ki-Bum Lee, and Jeong-Woo Choi

8 Biomimetic Nanostructures by Electrospinning and Electrospraying 123
Elham Vatankhah, Molamma P. Prabhakaran, and Seeram Ramakrishna

9 Nanoparticles for Stem-Cell Engineering 143
Esmaiel Jabbari

10 Toxicology of Nanobiomaterials 171
Shahin Bonakdar and Omid Mashinchian

Part 4 Control of Stem-Cell Fate by Engineering of Microenvironment 185

11 Stem-Cell Responses to Surface Nanotopographies 187
Peng-Yuan Wang and Wei-Bor Tsai

12 Control of Mesenchymal Stem-Cell Fate by Engineering the Nanoenvironment 205
Habib Nikukar, Stuart Reid, Mathis O. Riehle, Adam S.G. Curtis, and Matthew J. Dalby

13 Delivery of Molecules and Genes/Small Interfering RNA into Stem Cells by Nanoengineering 223
Mohsen Ashjari

Part 5 Nanotissue Engineering – Biological Approach along with Differentiation 243

14 Expansion of Stem Cells by Nanotissue Engineering 245
Amir Mellati and Hu Zhang

15 Nanotissue Engineering of Neural Cells 265
Sasan Jalili-Firoozinezhad, Fahimeh Mirakhori, and Hossein Baharvand

16 Nanotechnology and Cardiovascular Tissue Engineering 285
Savneet Kaur and Upasana Rishiraj

17 Nanotissue Engineering of Musculoskeletal Cells 299
Mohamadreza Baghaban Eslaminejad, Leila Taghiyar, and Fatemeh Safari

18 Nanotissue Engineering of Skin Cells 315
Daisy M. Ramos, Aditi Subramanian, Aja Aravamudhan, Matthew Harmon, Roshan James, Namdev B. Shelke, and Sangamesh G. Kumbar

19 High-Throughput Screening of Stem Cell Self-Renewal and Differentiation on Nanomaterials 327
Perry T. Yin, Tae-Hyung Kim, Jeong-Woo Choi, and Ki-Bum Lee

Part 6 Nanotechnology in Stem-Cell Imaging 345

20 Nanotechnology for Cellular Imaging 347
Miroslaw Janowski, P. Walczak, and J.W.M. Bulte

Part 7 Nanotissue Engineering and Clinical Applications 363

21 Advancing Translational Nanotechnology to Clinical Application 365
Michelle Griffin, Shima Salmasi, Naghmeh Naderi, Peter E. Butler, and Alexander M. Seifalian

22 Stem-Cell Nanoengineering from Bench to Bed 381
Omid Mashinchian, Shahin Bonakdar, Shahriar Sharifi, and Morteza Mahmoudi

Index 397

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