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RNA Interference : Application to Drug Discovery and Challenges to Pharmaceutical Development

ISBN: 9780471771517 | 0471771511

Edition: 1st
Format: Hardcover
Publisher: Wiley
Pub. Date: 2/15/2011

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Summary Table of Contents Author Biography

RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.

... MOREPhaseRx, Inc., Seattle, WA. Presents an overview of RNA interference. Topics include nucleic acids as regulatory molecules, genome scanning by RNA interference, discovery of new siRNA delivery agents, and application of RNA interference to viral diseases. For researchers. DNLM: RNA Interference.

A general overview of RNA interference for the novice reader Today, RNA molecules are used extensively in academic labs and the pharmaceutical industry to probe gene function and validate gene and protein targets for drug discovery. This book provides an overview of RNA interference for those unfamiliar with this rapidly emerging field. It covers mechanisms of action, its applications as a target validation and identification tool, toxicity concerns, and development of siRNA molecules as novel therapeutics. Written by experts in the field, each chapter focuses on an important aspect of RNAi biology or therapeutic discovery and application. While various aspects of current research, important discoveries, technology description, and methodology are covered, the book focuses on identifying issues that must be overcome for the successful development of RNAi technology. With a strong emphasis on issues and aspects that are important to a drug development team, the book: Presents a general overview of RNA interference biology, along with a strong emphasis on therapeutic applications issues important for drug development Addresses siRNA (small interfering RNA), a pharmaceutically-potent form, and how it is used in therapeutics, along with toxicity and delivery aspects Emphasizes industrial applications such as chemical modifications and delivery Focuses on gene function validation and siRNA as a new class of therapeutics Includes pharmaceutical topics of discovery and development of delivery agents, toxicity, and viral disease applications Clear, easy to understand, and focused on key issues for future research and development, RNA Interference is intended for non-specialist scientists, working in both academia and the pharmaceutical industry, who need to know and work within the dynamic area of RNA interference.

Biology of RNA Interference
RNA interference: What is it?
Nucleic acids as regulatory molecules
Use of siRNA oligonucleotides to study gene function
Genome scanning by RNA interference
Development of siRNA for Therapeutic Applications
Discovery of new siRNA delivery agents
In vivo Delivery of siRNA: challenges and strategies
... MORE
Application of RNA interference to viral diseases
Table of Contents provided by Publisher. All Rights Reserved.

Paul H. Johnson, PhD, is a cofounder and Chief Scientific Officer at PhaseRX, Inc. He is the author of numerous scientific papers and patents, and was the recipient of the 2007 Jeffery Wenig Memorial Award for Outstanding Achievement in Drug Delivery.

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