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Ribosome-inactivating Proteins Biology and Applications

ISBN: 9781118125656 | 1118125657
Edition: 1st
Format: Hardcover
Publisher: Wiley-Blackwell
Pub. Date: 6/9/2014

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This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain.


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