Since the publication of the first edition of Regenerative Biology and Medicine in 2006, steady advances have been made in understanding the origin and characteristics of stem cells in epithelia, skeletal muscle, and bone, and in the niche signals that regulate the activities of these cells. Simultaneously, breakthroughs including the creation of iPSCs and transdifferentiation have created a momentum for regenerative biology with implications in regenerative biology that are far-reaching. This book highlights these advances in the field to embrace a vast audience of investigators in chemistry, computer science, informatics, physics and mathematics as well as graduate students, clinical physicians, and biologists who are realizing the importance of the fields of regenerative biology and medicine in practice. Organized in three parts - biology of regeneration, regenerative medicine, and perspectives - this second edition creates a framework for integrating old and new data in this progressive field. Includes coverage od skin, hair, teeth, cornea, and central neural tissues Provides description of regenetive medicine in digestive, respiratory, urogenital, musculoskeletal, and cardiovascular systems Includes amphibians as powerful research models with discussion of appendage regeneration in amphibians and mammals