Completely updated for its Fifth Edition, this comprehensive text presents a practical approach to the office evaluation and management of every problem seen by primary care practitioners. In 239 problem-oriented chapters, the book provides essential information on medical diagnosis, lab tests, treatment options, and health maintenance and offers authoritative guidance on clinical decision-making. Every chapter of this edition ends with practical, bulleted Recommendations based on the best evidence, expert consensus guidelines, and clinical judgement. Annotated bibliographies in each chapter highlight the best available studies and analyses. This edition includes more Internet references and more evidence-based references that indicate evidence grades.