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Periodontal Medicine And Systems Biology

ISBN: 9781405122191 | 1405122196
Edition: 1st
Format: Hardcover
Publisher: Wiley-Blackwell
Pub. Date: 7/7/2009

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SummaryTable of ContentsAuthor Biography
This book provides a systems-based approach to periodontology and offers a scientific roadmap of the interactions which can lead to periodontal disease.The content is divided into five sections. The first introduces the reader to the concept of systems theory and its mathematical foundation. The second section provides the reader with a current view of periodontal medicine including the microbiology, molecular genetics, relationship to systemic disease and current and future therapies. Periodontitis is caused by members of the oral microbiota a... MORE
Prefacep. vii
Contributorsp. ix
Systems Theory and Cooperative Bacteria
Systems thinking in biologyp. 3
Metagenomics and its applications to human bacterial diseasesp. 21
Periodontitis: The Clinical Disease
Periodontitis: a modern clinical picturep. 33
Plaque microbiology in (periodontal) health and diseasep. 59
Population mo... MOREp. 77
Mechanisms linking periodontitis to systemic diseasep. 97
The impact of diabetes-enhanced inflammation on periodontal disease and bone destructionp. 117
Periodontitis: Coping with The Microbiota
The microbiota of humansp. 129
The normal oral microbiotap. 139
Bacterial coaggregation and periodontitisp. 151
Dynamics of biofilm formation and relationship to periodontitisp. 165
Quorum sensing as a means of biofilm communicationp. 177
Genomics of Porphyromonas gingivalisp. 193
Genomics of Fusobacterium nucleatump. 205
The Aggregatibacter (formerly Actinobacillus) actinomycetemcomitans genomeannotation, analysis and metabolic reconstructionp. 219
Periodontitis: Innate and Acquired Immunity
A new view of innate immunity for the twenty-first centuryp. 247
Innate immunity and homeostasis in the periodontiump. 263
Antimicrobial host defence peptides in oral health and periodontitisp. 279
Control of inflammation in periodontal diseasep. 299
Antigen-presenting cells in chronic periodontitisp. 317
B-cell responses in periodontitisp. 339
T-cell responses in periodontitisp. 357
Periodontitis: Bone Destruction
Current paradigms of osteoblast-osteoclast interactions and bacterial pathogen-induced bone resorptionp. 379
Bacterial osteolytic mediatorsp. 395
Immune cell involvement in periodontal bone lossp. 407
How can periodontal bone loss be stopped?p. 427
Indexp. 439
Table of Contents provided by Ingram. All Rights Reserved.
Brian Henderson is Professor of Cell Biology in the Division of Microbial Diseases at UCL Eastman Dental Institute, University College London.

Michael A Curtis is Professor of Microbiology and Director of the Institute of Cell and Molecular Science at Barts and The London School of Medicine and Dentistry.

Robert M Seymour is Professor in the UCL Department of Mathematics, University College London.

Professor Nikos Donos is Director of Research Strategy and Head of Periodontology at UCL Eastman Dental Institute, University College London.



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