Rent 9780470712368 | Organic Synthesis : The Disconnection Approach | Warren, Stuart; Wyatt, Paul @knetbooks.com

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Summary Table of Contents

Organic Synthesis: The Disconnection Approach is the long-awaited second edition of a classic textbook; the first to provide a structured course in retrosynthesis- now an important technique used by generations of organic chemists. Now fully revised and updated with a modern look, 25 years of advances in organic synthesis are reflected with the addition of new examples and synthetic pathways. Additional material has been added to take the student to the level required by the bestselling sequel, "Organic Synthesis: Strategy and Control" and the ... MORElater chapters have extensive new material based on courses that the authors give to chemists in the pharmaceutical industry.

One approach to organic synthesis is retrosynthetic analysis. With this approach a chemist will start with the structure of their target molecule and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This �disconnection� approach to synthesis is now a fundamental part of every organic synthesis course.

Organic Synthesis: The Disconnection Approach, 2^nd Edition introduces this important technique, to help students to design their own organic syntheses. There are forty chapters: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems.

Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given.

This second edition has been fully revised and updated with a modern look. Recent examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, �Organic Synthesis: Strategy and Control�.

Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry.

Organic Synthesis: The Disconnection Approach, 2^nd edition provides a full course in retrosynthetic analysis for chemistry and biochemistry students and a refresher for organic chemists working in industry and academia.

Preface	p. ix
General References	p. xi
The Disconnection Approach	p. 1
Basic Principles: Synthons and Reagents Synthesis of Aromatic Compounds	p. 7
Strategy I: The Order of Events	p. 17
One-Group C-X Disconnections	p. 23
Strategy II: Chemoselectivity	p. 29
Two-Group C-X Disconnections	p. 35
Strategy III: Reversal of Polarity, Cyclisa... MOREtions, Summary of Strategy	p. 45
Amine Synthesis	p. 53
Strategy IV: Protecting Groups	p. 61
One Group C-C Disconnections I: Alcohols	p. 69
General Strategy A: Choosing a Disconnection	p. 77
Strategy V: Stereoselectivity A	p. 83
One Group C-C Disconnections II: Carbonyl Compounds	p. 93
Strategy VI: Regioselectivity	p. 101
Alkene Synthesis	p. 107
Strategy VII: Use of Acetylenes (Alkynes)	p. 115
Two-Group C-C Disconnections I: Diels-Alder Reactions	p. 121
Strategy VIII: Introduction to Carbonyl Condensations	p. 129
Two-Group C-C Disconnections II: 1,3-Difunctionalised Compounds	p. 133
Strategy IX: Control in Carbonyl Condensations	p. 139
Two-Group C-C Disconnections III: 1,5-Difunctionalised Compounds Conjugate (Michael) Addition and Robinson Annelation	p. 151
Strategy X: Aliphatic Nitro Compounds in Synthesis	p. 161
Two-Group Disconnections IV: 1,2-Difunctionalised Compounds	p. 167
Strategy XI: Radical Reactions in Synthesis	p. 177
Two-Group Disconnections V: 1,4-Difunctionalised Compounds	p. 185
Strategy XII: Reconnection	p. 193
Two-Group C-C Disconnections VI: 1,6-diCarbonyl Compounds	p. 199
General Strategy B: Strategy of Carbonyl Disconnections	p. 207
Strategy XIII: Introduction to Ring Synthesis: Saturated Heterocycles	p. 217
Three-Membered Rings	p. 229
Strategy XIV: Rearrangements in Synthesis	p. 237
Four-Membered Rings: Photochemistry in Synthesis	p. 245
Strategy XV: The Use of Ketenes in Synthesis	p. 251
Five-Membered Rings	p. 255
Strategy XVI: Pericyclic Reactions in Synthesis: Special Methods for Five-Membered Rings	p. 261
Six-Membered Rings	p. 269
General Strategy C: Strategy of Ring Synthesis	p. 279
Strategy XVII: Stereoselectivity B	p. 289
Aromatic Heterocycles	p. 301
General Strategy D: Advanced Strategy	p. 313
Index	p. 325
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