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| A Brief History of Microbiology | p. 1 |
| The Early Years of Microbiology | p. 2 |
| What Does Life Really Look Like? | p. 2 |
| How Can Microbes Be Classified? | p. 3 |
| The Golden Age of Microbiology | p. 7 |
| Is Spontaneous Generation of Microbial Life Possible? | p. 7 |
| What Causes Fermentation? | p. 10 |
| What Causes Disease? | p. 10 |
| How Can We Prevent Infection and... MORE | p. 16 |
| The Modern Age of Microbiology | p. 18 |
| What Are the Basic Chemical Reactions of Life? | p. 19 |
| How Do Genes Work? | p. 19 |
| What Roles Do Microorganisms Play in the Environment? | p. 21 |
| How Do We Defend Against Disease? | p. 21 |
| What Will the Future Hold? | p. 21 |
| Chapter Summary | p. 22 |
| Questions for Review | p. 23 |
| The Chemistry of Microbiology | p. 25 |
| Atoms | p. 26 |
| Atomic Structure | p. 26 |
| Isotopes | p. 26 |
| Electron Configurations | p. 27 |
| Chemical Bonds | p. 28 |
| Nonpolar Covalent Bonds | p. 29 |
| Polar Covalent Bonds | p. 31 |
| Ionic Bonds | p. 32 |
| Hydrogen Bonds | p. 33 |
| Chemical Reactions | p. 34 |
| Synthesis Reactions | p. 34 |
| Decomposition Reactions | p. 34 |
| Exchange Reactions | p. 35 |
| Water, Acids, Bases, and Salts | p. 35 |
| Water | p. 35 |
| Acids and Bases | p. 37 |
| Salts | p. 38 |
| Organic Macromolecules | p. 38 |
| Functional Groups and Monomers | p. 38 |
| Lipids | p. 39 |
| Carbohydrates | p. 42 |
| Proteins | p. 46 |
| Nucleic Acids | p. 49 |
| Chapter Summary | p. 52 |
| Questions for Review | p. 53 |
| Cell Structure and Function | p. 55 |
| Processes of Life | p. 56 |
| Eukaryotic and Prokaryotic Cells: An Overview | p. 57 |
| External Structures of Prokaryotic Cells | p. 60 |
| Glycocalyces | p. 60 |
| Flagella | p. 61 |
| Fimbriae and Pili | p. 64 |
| Prokaryotic Cell Walls | p. 65 |
| Bacterial Cell Walls | p. 65 |
| Archaeal Cell Walls | p. 67 |
| Prokaryotic Cytoplasmic Membranes | p. 69 |
| Structure | p. 69 |
| Function | p. 70 |
| Cytoplasm of Prokaryotes | p. 74 |
| Cytosol | p. 74 |
| Inclusions | p. 74 |
| Endospores | p. 74 |
| Nonmembranous Organelles | p. 76 |
| External Structure of Eukaryotic Cells | p. 77 |
| Glycocalyces | p. 77 |
| Eukaryotic Cell Walls and Cytoplasmic Membranes | p. 77 |
| Cytoplasm of Eukaryotes | p. 80 |
| Flagella | p. 80 |
| Cilia | p. 81 |
| Other nonmembranous Organelles | p. 81 |
| Membranous Organelles | p. 82 |
| Endosymbiotic Theory | p. 85 |
| Chapter Summary | p. 88 |
| Questions for Review | p. 90 |
| Microscopy, Staining, and Classification | p. 93 |
| Units of Measurement | p. 94 |
| Microscopy | p. 94 |
| General Principles of Microscopy | p. 94 |
| Light Microscopy | p. 96 |
| Electron Microscopy | p. 102 |
| Probe Microscopy | p. 104 |
| Staining | p. 105 |
| Preparing Specimens for Staining | p. 105 |
| Principles of Staining | p. 107 |
| Simple Stains | p. 107 |
| Differential Stains | p. 107 |
| Special Stains | p. 110 |
| Staining for Electron Microscopy | p. 112 |
| Classification and Identification of Microorganisms | p. 112 |
| Linnaeus, Whitaker, and Taxonomic Categories | p. 112 |
| Domains | p. 115 |
| Taxonomic and Identifying Characteristics | p. 115 |
| Taxonomic Keys | p. 119 |
| Chapter Summary | p. 120 |
| Questions for Review | p. 121 |
| Microbial Metabolism | p. 123 |
| Basic Chemical Reactions Underlying Metabolism | p. 124 |
| Catabolism and Anabolism | p. 124 |
| Oxidation and Reduction Reactions | p. 125 |
| ATP Production and Energy Storage | p. 126 |
| The Roles of Enzymes in Metabolism | p. 126 |
| Carbohydrate Catabolism | p. 133 |
| Glycolysis | p. 134 |
| Alternatives to Glycolysis | p. 137 |
| Continuation of Cellular Respiration | p. 139 |
| Fermentation | p. 146 |
| Other Catabolic Pathways | p. 147 |
| Lipid Catabolism | p. 147 |
| Protein Catabolism | p. 149 |
| Photosynthesis | p. 149 |
| Chemicals and Structures | p. 150 |
| Light-Dependent Reactions | p. 151 |
| Light-Independent Reactions | p. 154 |
| Other Anabolic Pathways | p. 154 |
| Carbohydrate Biosynthesis | p. 155 |
| Lipid Biosynthesis | p. 156 |
| Amino Acid Biosynthesis | p. 156 |
| Nucleotide Biosynthesis | p. 158 |
| Integration and Regulation of Metabolic Functions | p. 158 |
| Chapter Summary | p. 161 |
| Questions for Review | p. 162 |
| Microbial Nutrition and Growth | p. 165 |
| Growth Requirements | p. 166 |
| Nutrients: Chemical and Energy Requirements | p. 166 |
| Physical Requirements | p. 170 |
| Ecological Associations | p. 174 |
| Culturing Microorganisms | p. 174 |
| Clinical Sampling | p. 175 |
| Obtaining Pure Cultures | p. 176 |
| Culture Media | p. 178 |
| Special Culture Techniques | p. 182 |
| Preserving Cultures | p. 184 |
| Growth of Microbial Populations | p. 184 |
| Mathematical Considerations in Population Growth | p. 185 |
| Generation Time | p. 185 |
| Phases of Microbial Growth | p. 186 |
| Measuring Microbial Growth | p. 187 |
| Chapter Summary | p. 192 |
| Questions for Review | p. 194 |
| Microbial Genetics | p. 196 |
| The Structure and Replication of Genomes | p. 197 |
| The Structure of Nucleic Acids | p. 197 |
| The Structure of Prokaryotic Genomes | p. 197 |
| The Structure of Eukaryotic Genomes | p. 200 |
| DNA Replication | p. 201 |
| Gene Function | p. 205 |
| The Relationship Between Genotype and Phenotype | p. 205 |
| The Transfer of Genetic Information | p. 206 |
| The Events in Transcription | p. 206 |
| Translation | p. 210 |
| Regulation of Genetic Expression | p. 216 |
| Mutations of Genes | p. 220 |
| Types of Mutations | p. 220 |
| Effects of Mutations | p. 220 |
| Mutagens | p. 220 |
| Frequency of Mutation | p. 223 |
| DNA Repair | p. 223 |
| Identifying Mutants, Mutagens, and Carcinogens | p. 225 |
| Genetic Recombination and Transfer | p. 227 |
| Horizontal Gene Transfer Among Prokaryotes | p. 227 |
| Transposons and Transposition | p. 232 |
| Chapter Summary | p. 234 |
| Questions for Review | p. 236 |
| Recombinant DNA Technology | p. 239 |
| The Role of Recombinant DNA Technology in Biotechnology | p. 240 |
| The Tools of Recombinant DNA Technology | p. 240 |
| Mutagens | p. 240 |
| The Use of Reverse Transcriptase to Synthesize cDNA | p. 241 |
| Synthetic Nucleic Acids | p. 241 |
| Restriction Enzymes | p. 242 |
| Vectors | p. 243 |
| Gene libraries | p. 244 |
| Techniques of Recombinant DNA Technology | p. 245 |
| Multiplying DNA in vitro: The Polymerase Chain Reaction (PCR) | p. 245 |
| Selecting a Clone of Recombinant Cells | p. 246 |
| Separating DNA Molecules: Gel Electrophoresis and the Southern Blot | p. 246 |
| DNA Microarrays | p. 249 |
| Inserting DNA into Cells | p. 250 |
| Applications of Recombinant DNA Technology | p. 250 |
| Genome Mapping | p. 250 |
| Pharmaceutical and Therapeutic Applications | p. 253 |
| Agricultural Applications | p. 256 |
| The Ethics and Safety of Recombinant DNA Technology | p. 257 |
| Chapter Summary | p. 258 |
| Questions for Review | p. 259 |
| Controlling Microbial Growth in the Environment | p. 261 |
| Basic Principles of Microbial Control | p. 262 |
| Terminology of Microbial Control | p. 262 |
| Microbial Death Rates | p. 263 |
| Action of Antimicrobial Agents | p. 264 |
| The Selection of Microbial Control Methods | p. 264 |
| Factors Affecting the Efficacy of Antimicrobial Methods | p. 264 |
| Methods for Evaluating Disinfectants and Antiseptics | p. 265 |
| Physical Methods of Microbial Control | p. 267 |
| Heat-Related Methods | p. 267 |
| Refrigeration and Freezing | p. 270 |
| Desiccation and Lyophilization | p. 271 |
| Filtration | p. 271 |
| Osmotic Pressure | p. 273 |
| Radiation | p. 273 |
| Chemical Methods of Microbial Control | p. 276 |
| Phenol and Phenolics | p. 276 |
| Alcohols | p. 277 |
| Halogens | p. 277 |
| Oxidizing Agents | p. 278 |
| Surfactants | p. 278 |
| Heavy Metals | p. 278 |
| Aldehydes | p. 279 |
| Gaseous Agents | p. 280 |
| Antimicrobials | p. 281 |
| Development of Resistant Microbes | p. 281 |
| Chapter Summary | p. 282 |
| Questions for Review | p. 283 |
| Controlling Microbial Growth in the Body: Antimicrobial Drugs | p. 286 |
| The History of Antimicrobial Agents | p. 287 |
| Mechanisms of Antimicrobial Action | p. 288 |
| Inhibition of Cell Wall Synthesis | p. 289 |
| Inhibition of Protein Synthesis | p. 291 |
| Disruption of Cytoplasmic Membranes | p. 292 |
| Inhibition of Metabolic Pathways | p. 293 |
| Inhibition of Nucleic Acid Synthesis | p. 294 |
| Prevention of Virus Attachment | p. 296 |
| Clinical Considerations in Prescribing Antimicrobial Drugs | p. 296 |
| Spectrum of Action | p. 296 |
| Efficacy | p. 297 |
| Routes of Administration | p. 299 |
| Safety and Side Effects | p. 300 |
| Resistance to Antimicrobial Drugs | p. 301 |
| The Development of Resistance in Populations | p. 301 |
| Mechanisms of Resistance | p. 302 |
| Multiple Resistance and Cross Resistance | p. 303 |
| Retarding Resistance | p. 303 |
| Chapter Summary | p. 312 |
| Questions for Review | p. 313 |
| Characterizing and Classifying Prokaryotes | p. 315 |
| General Characteristics of Prokaryotic Organisms | p. 316 |
| Morphology of Prokaryotic Cells | p. 316 |
| Reproduction of Prokaryotic Cells | p. 316 |
| Arrangements of Prokaryotic Cells | p. 317 |
| Endospores | p. 318 |
| Modern Prokaryotic Classification | p. 319 |
| Survey of Archaea | p. 320 |
| Extremophiles | p. 321 |
| Methanogens | p. 323 |
| Survey of Bacteria | p. 323 |
| Deeply Branching and Phototrophic Bacteria | p. 323 |
| Low G + C Gram-Positive Bacteria | p. 326 |
| High G + C Gram-Positive Bacteria | p. 330 |
| Gram-Negative Proteobacteria | p. 331 |
| Other Gram-Negative Bacteria | p. 338 |
| Chapter Summary | p. 339 |
| Questions for Review | p. 341 |
| Characterizing and Classifying Eukaryotes | p. 343 |
| General Characteristics of Eukaryotic Organisms | p. 344 |
| Reproduction in Eukaryotes | p. 344 |
| The Classification of Eukaryotic Organisms | p. 348 |
| Protozoa | p. 349 |
| Distribution of Protozoa | p. 349 |
| Morphology of Protozoa | p. 349 |
| Nutrition of Protozoa | p. 350 |
| Reproduction in Protozoa | p. 350 |
| Classification of Protozoa | p. 352 |
| Fungi | p. 357 |
| The Significance of Fungi | p. 358 |
| Morphology of Fungi | p. 359 |
| Nutrition of Fungi | p. 360 |
| Reproduction in Fungi | p. 360 |
| Classification of Fungi | p. 362 |
| Lichens | p. 367 |
| Algae | p. 368 |
| Distribution of Algae | p. 368 |
| Morphology of Algae | p. 368 |
| Reproduction in Algae | p. 368 |
| Classification of Algae | p. 369 |
| Water Molds | p. 373 |
| Other Eukaryotes of Microbiological Interest: Parasitic Helminths and Vectors | p. 373 |
| Chapter Summary | p. 373 |
| Questions for Review | p. 375 |
| Characterizing and Classifying Viruses, Viroids, and Prions | p. 377 |
| Characteristics of Viruses | p. 378 |
| Genetic Material of Viruses | p. 379 |
| Hosts of Viruses | p. 379 |
| Sizes of Viruses | p. 380 |
| Capsid Morphology | p. 380 |
| Viral Shapes | p. 381 |
| The Viral Envelope | p. 381 |
| Classification of Viruses | p. 382 |
| Viral Replication | p. 385 |
| Lytic Replication of Bacteriohages | p. 385 |
| Lysogeny | p. 388 |
| Replication of Animal Viruses | p. 390 |
| The Role of Viruses in Cancer | p. 394 |
| Culturing Viruses in the Laboratory | p. 396 |
| Culturing Viruses in Whole Organisms | p. 396 |
| Culturing Viruses in Embryonated Chicken Eggs | p. 396 |
| Culturing Viruses in Cell (Tissue) Culture | p. 397 |
| Other Parasitic Particles: Viroids and Prions | p. 398 |
| Characteristics of Viroids | p. 398 |
| Characteristics of Prions | p. 398 |
| Are Viruses Alive? | p. 401 |
| Chapter Summary | p. 401 |
| Questions for Review | p. 402 |
| Infection, Infectious Diseases, and Epidemiology | p. 404 |
| Symbiotic Relationships Between Microbes and Their Hosts | p. 405 |
| Types of Symbiosis | p. 405 |
| Normal Microbiota in Hosts | p. 406 |
| How Normal Microbiota Become Opportunistic Pathogens | p. 407 |
| The Movement of Microbes into Hosts: Infection | p. 409 |
| Exposure to Microbes: Contamination and Infection | p. 409 |
| Portals of Entry | p. 409 |
| The Role of Adhesion in Infection | p. 410 |
| The Nature of Infectious Disease | p. 411 |
| Manifestations of Disease: Symptoms, Signs, and Syndromes | p. 412 |
| Causation of Disease: Etiology | p. 412 |
| Virulence Factors of Infectious Agents | p. 415 |
| The Stages of Infectious Diseases | p. 418 |
| The Movement of Pathogens Out of Hosts: Portals of Exit | p. 419 |
| Sources of Infectious Diseases in Humans | p. 419 |
| Animal Reservoirs | p. 420 |
| Human Carriers | p. 420 |
| Nonliving Reservoirs | p. 420 |
| Modes of Infectious Disease Transmission | p. 420 |
| Contact Transmission | p. 422 |
| Vehicle Transmission | p. 423 |
| Vector Transmission | p. 423 |
| Classification of Infectious Diseases | p. 423 |
| Epidemiology of Infectious Diseases | p. 424 |
| Frequency of Disease | p. 425 |
| Epidemiological Studies | p. 426 |
| Hospital Epidemiology: Nosocomial Infections | p. 430 |
| Epidemiology and Public Health | p. 432 |
| Chapter Summary | p. 433 |
| Questions for Review | p. 435 |
| Innate Immunity | p. 437 |
| An Overview of the Body's Defenses | p. 438 |
| The Body's First Line of Defense | p. 438 |
| The Role of Skin in Nonspecific Defense | p. 438 |
| The Role of Mucous Membranes in Nonspecific Defense | p. 439 |
| The Role of Normal Microbiota in Nonspecific Defense | p. 440 |
| Other First-Line Defenses | p. 441 |
| An Overview of the Body's Second Line of Defense | p. 442 |
| Defense Components of Blood | p. 443 |
| The Body's Second Line of Defense | p. 445 |
| Phagocytosis | p. 445 |
| Extracellular Killing by Leukocytes | p. 448 |
| Nonspecific Chemical Defenses Against Pathogens | p. 449 |
| Inflammation | p. 452 |
| Fever | p. 456 |
| Chapter Summary | p. 458 |
| Questions for Review | p. 459 |
| Specific Defense: Adaptive Immunity | p. 461 |
| Elements of Adaptive Immunity (Specific) | p. 462 |
| Antigens | p. 462 |
| The Cells, Tissues, and Organs of the Lymphatic System | p. 464 |
| B Lymphocytes (B Cells) and Antibodies | p. 466 |
| T Lymphocytes (T Cells) | p. 469 |
| Immune System Cytokines | p. 471 |
| The Body's Preparation for a Specific Adaptive Immune Response | p. 472 |
| Lymphocyte Editing by Clonal Deletion | p. 472 |
| The Roles of the Major Histocompatibility Complex | p. 473 |
| Antigen Processing | p. 474 |
| The Humoral Immune Response | p. 476 |
| B Cell Activation and Clonal Selection | p. 476 |
| Memory B Cells and the Establishment of Immunological Memory | p. 476 |
| The Cell-Mediated Immune Response | p. 478 |
| The Perforin-Granzyme Cytotoxic Pathway | p. 479 |
| The CD95 Cytotoxic Pathway | p. 480 |
| Memory T Cells | p. 480 |
| T Cell Regulation | p. 480 |
| Types of Acquired Immunity | p. 481 |
| Naturally Acquired Active Immunity | p. 481 |
| Naturally Acquired Passive Immunity | p. 481 |
| Artificially Acquired Active Immunity | p. 481 |
| Artificially Acquired Passive Immunity | p. 481 |
| Chapter Summary | p. 482 |
| Questions for Review | p. 483 |
| Immunization and Immune Testing | p. 485 |
| Immunization | p. 486 |
| Brief History of Immunization | p. 486 |
| Active Immunization | p. 487 |
| Passive Immunization | p. 492 |
| Immune Testing | p. 493 |
| Precipitation Tests | p. 494 |
| Agglutination Tests | p. 497 |
| Neutralization Tests | p. 498 |
| The Complement Fixation Test | p. 498 |
| Labeled Antibody Tests | p. 499 |
| Recent Developments in Immune Testing | p. 502 |
| Chapter Summary | p. 504 |
| Questions for Review | p. 505 |
| Hypersensitivities, Autoimmune Diseases, and Immune Deficiencies | p. 507 |
| Hypersensitivities | p. 508 |
| (Immediate) Hypersensitivity | p. 508 |
| (Cytotoxic) Hypersensitivity | p. 512 |
| (Immune-Complex Mediated) Hypersensitivity | p. 515 |
| (Delayed or Cell-Mediated) Hypersensitivity | p. 516 |
| Autoimmune Diseases | p. 521 |
| Causes of Autoimmune Diseases | p. 521 |
| Single Tissue Autoimmune Diseases | p. 522 |
| Systemic Autoimmune Diseases | p. 522 |
| Immunodeficiency Diseases | p. 524 |
| Primary Immunodeficiency Diseases | p. 524 |
| Acquired Immunodeficiency Diseases | p. 525 |
| Chapter Summary | p. 526 |
| Questions for Review | p. 527 |
| Pathogenic Gram-Positive Cocci and Bacilli | p. 529 |
| Staphylococcus | p. 530 |
| Structure and Physiology | p. 530 |
| Pathogenicity | p. 531 |
| Epidemiology | p. 531 |
| Staphylococcal Diseases | p. 532 |
| Diagnosis, Treatment, and Prevention | p. 534 |
| Streptococcus | p. 535 |
| Group A Streptococcus: Streptococcus pyogenes | p. 535 |
| Group B Streptococcus: Streptococcus agalactiae | p. 538 |
| Other Beta-Hemolytic Streptococci | p. 538 |
| Alpha-Hemolytic Streptococci: The Viridans Group | p. 539 |
| Streptococcus pneumoniae | p. 539 |
| Enterococcus | p. 540 |
| Structure and Physiology | p. 541 |
| Pathogenesis, Epidemiology, and Diseases | p. 541 |
| Diagnosis, Treatment, and Prevention | p. 541 |
| Bacillus | p. 542 |
| Structure, Physiology, and Pathogenicity | p. 542 |
| Epidemiology | p. 543 |
| Disease | p. 543 |
| Diagnosis, Treatment, and Prevention | p. 544 |
| Clostridium | p. 544 |
| Clostridium perfringens | p. 544 |
| Clostridium difficile | p. 545 |
| Clostridium botulinum | p. 545 |
| Clostridium tetani | p. 548 |
| Listeria | p. 550 |
| Pathogenesis, Epidemiology, and Disease | p. 550 |
| Diagnosis, Treatment, and Prevention | p. 550 |
| Corynebacterium | p. 551 |
| Pathogenesis, Epidemiology, and Disease | p. 552 |
| Diagnosis, Treatment, and Prevention | p. 552 |
| Mycobacterium | p. 553 |
| Tuberculosis | p. 553 |
| Leprosy | p. 557 |
| Other Mycobacterial Infections in AIDS Patients | p. 558 |
| Propionibacterium | p. 558 |
| Nocardia and Actinomyces | p. 558 |
| Nocardia asteroides | p. 559 |
| Actinomyces | p. 560 |
| Chapter Summary | p. 560 |
| Questions for Review | p. 562 |
| Pathogenic Gram-Negative Cocci and Bacilli | p. 564 |
| Pathogenic Gram-Negative Cocci: Neisseria | p. 565 |
| Structure and Physiology of Neisseria | p. 565 |
| The Gonococcus: Neisseria gonorrhoeae | p. 566 |
| The Meningococcus: Neisseria meningitidis | p. 567 |
| Pathogenic, Gram-Negative, Facultatively Anaerobic Bacilli | p. 569 |
| The Enterobacteriaceae: An Overview | p. 569 |
| Coliform Opportunistic Enterobacteriaceae | p. 572 |
| Noncoliform Opportunistic Enterobacteriaceae | p. 575 |
| Truly Pathogenic Enterobacteriaceae | p. 576 |
| The Pasteurellaceae | p. 580 |
| Pathogenic, Gram-Negative, Aerobic Bacilli | p. 582 |
| Bartonella | p. 582 |
| Brucella | p. 582 |
| Bordetella | p. 583 |
| Burkholderia | p. 585 |
| Pseudomonads | p. 586 |
| Francisella | p. 587 |
| Legionella | p. 588 |
| Coxiella | p. 589 |
| Pathogenic, Gram-Negative, Anaerobic Bacilli | p. 590 |
| Bacteroides | p. 590 |
| Prevotella | p. 591 |
| Chapter Summary | p. 591 |
| Questions for Review | p. 592 |
| Mycoplasmas, Rickettsias, Chlamydias, Spirochetes, and Vibrios | p. 594 |
| Mycoplasmas | p. 595 |
| Mycoplasma pneumoniae | p. 596 |
| Other Mycoplasmas | p. 596 |
| Rickettsias | p. 597 |
| Rickettsia | p. 597 |
| Orienta | p. 599 |
| Ehrlichia | p. 600 |
| Chlamydias | p. 601 |
| Chlamydia trachomatis | p. 602 |
| Chlamydia pneumoniae | p. 604 |
| Chlamydia psittaci | p. 604 |
| Spirochetes | p. 606 |
| Treponema | p. 606 |
| Borrelia | p. 609 |
| Leptospira | p. 612 |
| Pathogenic Gram-Negative Vibrios | p. 613 |
| Vibrio | p. 613 |
| Campylobacter jejuni | p. 615 |
| Helicobacter pylori | p. 616 |
| Chapter Summary | p. 618 |
| Questions for Review | p. 619 |
| Pathogenic Fungi | p. 622 |
| An Overview of Medical Mycology | p. 623 |
| The Epidemiology of Mycoses | p. 623 |
| Categories of Fungal Agents: True Fungal Pathogens and Opportunistic Fungi | p. 623 |
| Clinical Manifestations of Fungal Diseases | p. 625 |
| The Diagnosis of Fungal Infections | p. 626 |
| Antifungal Therapies | p. 626 |
| Systemic Mycoses Caused by Pathogenic Fungi | p. 627 |
| Blastomycosis | p. 627 |
| Coccidioidomycosis | p. 628 |
| Histoplasmosis | p. 629 |
| Paracoccidioidomycosis | p. 629 |
| Systemic Mycoses Caused by Opportunistic Fungi | p. 631 |
| Aspergillosis | p. 631 |
| Candidiasis | p. 632 |
| Cryptococcosis | p. 634 |
| Pneumocystis Pneumonia | p. 635 |
| Zygomycoses | p. 636 |
| The Emergence of Fungal Opportunists in Immunosuppressed Individuals | p. 636 |
| Superficial, Cutaneous, and Subcutaneous Mycoses | p. 637 |
| Superficial Mycoses | p. 637 |
| Cutaneous and Subcutaneous Mycoses | p. 640 |
| Fungal Intoxications and Allergies | p. 642 |
| Mycotoxicoses | p. 642 |
| Mycetismus: Mushroom Poisoning | p. 643 |
| Allergies to Fungi | p. 643 |
| Chapter Summary | p. 644 |
| Questions for Review | p. 645 |
| Parasitic Protozoa, Helminths, and Arthropod Vectors | p. 648 |
| Protozoan Parasites of Humans | p. 650 |
| Ciliates | p. 650 |
| Amoebae | p. 650 |
| Flagellates | p. 652 |
| Apicomplexans | p. 658 |
| Helminthic Parasites of Humans | p. 663 |
| Cestodes | p. 664 |
| Trematodes | p. 666 |
| Nematodes | p. 669 |
| Arthropod Vectors | p. 672 |
| Arachnids | p. 673 |
| Insects | p. 673 |
| Chapter Summary | p. 675 |
| Questions for Review | p. 676 |
| Pathogenic DNA Viruses | p. 679 |
| Poxviridae | p. 680 |
| Smallpox | p. 680 |
| Molluscum Contagiosum | p. 682 |
| Other Poxvirus Infections | p. 682 |
| Herpesviridae | p. 682 |
| Infections of Human Herpesviruses 1 and 2 | p. 683 |
| Varicella-Zoster Virus Infections | p. 687 |
| Epstein-Barr Virus Infections | p. 689 |
| Cytomegalovirus Infections | p. 691 |
| Other Herpesvirus Infections | p. 692 |
| Papillomaviridae and Polyomaviridae | p. 692 |
| Papillomavirus Infections | p. 693 |
| Polyomavirus Infections | p. 694 |
| Adenoviridae | p. 695 |
| Hepadnaviridae | p. 696 |
| Hepatitis B Infections | p. 697 |
| The Role of Hepatitis B Virus in Hepatic Cancer | p. 699 |
| Parvoviridae | p. 699 |
| Chapter Summary | p. 700 |
| Questions for Review | p. 701 |
| Pathogenic RNA Viruses | p. 703 |
| Naked, Positive ssRNA Viruses: Picornaviridae, Caliciviridae, Astroviridae, and Hepeviridae | p. 704 |
| Common Colds Caused by Rhinoviruses | p. 704 |
| Diseases of Enteroviruses | p. 705 |
| Hepatitis A | p. 708 |
| Acute Gastroenteritis and Hepatitis E | p. 709 |
| Enveloped, Positive ssRNA Viruses: Togaviridae, Flaviviridae, and Coronaviridae | p. 710 |
| Diseases of +RNA Arboviruses | p. 710 |
| Other Diseases of Enveloped +ssRNA Viruses | p. 710 |
| Rubella | p. 713 |
| Hepatitis C | p. 714 |
| Diseases of Coronaviruses | p. 715 |
| Enveloped, Positive ssRNA Viruses with Reverse Transcriptase: Retroviridae | p. 715 |
| Oncogenic Retroviruses | p. 717 |
| Acquired Immunodeficiency Syndrome | p. 717 |
| Enveloped, Unsegmented, Negative ssRNA Viruses: Paramyxoviridae, Rhabdoviridae, and Filoviridae | p. 724 |
| Measles | p. 724 |
| Diseases of Parainfluenza Virus | p. 726 |
| Mumps | p. 726 |
| Disease of Respiratory Syncytial Virus | p. 727 |
| Rabies | p. 728 |
| Hemorrhagic Fevers | p. 730 |
| Enveloped, Segmented, Negative ssRNA Viruses: Orthomyxoviridae, Bunyaviridae, and Arenaviridae | p. 731 |
| Influenza | p. 731 |
| Diseases of Bunyaviruses | p. 735 |
| Diseases of Arenaviruses | p. 735 |
| Naked, Segmented dsRNA Viruses: Reoviridae | p. 736 |
| Rotaviruses | p. 736 |
| Coltiviruses | p. 737 |
| Chapter Summary | p. 738 |
| Questions for Review | p. 740 |
| Applied and Environmental Microbiology | p. 742 |
| Food Microbiology | p. 743 |
| The Roles of Microorganisms in Food Production | p. 743 |
| The Causes and Prevention of Food Spoilage | p. 747 |
| Food-Borne Illnesses | p. 750 |
| Industrial Microbiology | p. 751 |
| The Roles of Microbes in Industrial Fermentations | p. 751 |
| Industrial Products of Microorganisms | p. 752 |
| Water and Wastewater Treatment | p. 754 |
| Bioremediation | p. 760 |
| The Problem of Acid Mine Drainage | p. 761 |
| Environmental Microbiology | p. 762 |
| Microbial Ecology | p. 762 |
| The Roles of Microorganisms in Biogeochemical Cycles | p. 764 |
| Soil Microbiology | p. 767 |
| Aquatic Microbiology | p. 768 |
| Biological Warfare and Bioterrorism | p. 771 |
| Assessing Microorganisms as Potential Agents of Warfare or Terror | p. 771 |
| Known Microbial Threats | p. 772 |
| Defense Against Bioterrorism | p. 772 |
| The Roles of Recombinant Genetic Technology in Bioterrorism | p. 774 |
| Chapter Summary | p. 774 |
| Questions for Review | p. 776 |
| Metabolic Pathways | p. 1 |
| Some Mathematical Considerations in Microbiology | p. 1 |
| Classification of Bacteria According to Bergey's Manual | p. 1 |
| Major Microbial Agents of Disease by Body System Affected | p. 1 |
| Answers to End-of-Chapter Questions | p. 1 |
| Glossary | p. 1 |
| Index | p. 1 |
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