Much about this third edition of A Guide to Treatments That Work remains as it was in the first and second editions. Like its predecessors, this edition offers detailed evaluative reviews of current research on empirically supported treatments, written in most instances by clinical psychologists and psychiatrists who are major contributors to that literature. Similarly, the standards by which the authors were asked to evaluate the methodological rigor of the research on treatments have also remained the same. As before, they provide information on the quality of the research on treatment efficacy and effectiveness that is reviewed. A few changes have been made in the substance of the book. Three chapters have been added. They cover treatments for conditions for which empirically supported treatments have only recently emerged. The first reviews current data on treatments for pathological gambling and other impulse control disorders. As our society extends gambling venues, the number of pathological gamblers has increased proportionately. Hence, there is clear need for effective treatments for gambling problems. The second of the new chapters evaluates psychosocial treatments for posttraumatic stress disorder. The dramatic recent increase in patients diagnosed with PTSD, in large part reflecting psychological casualties from the war in Iraq, has made the search for effective PTSD treatments more compelling than ever. Finally, the concluding chapter of the volume provides a comprehensive review of the efficacy of combined psychopharmacological and psychosocial treatments for the major depressive disorders and anxiety disorders. This chapter recognizes the growing use of combined treatments for many disorders for which monotherapies had previously been the rule. A column has been added to the Summary of Treatments That Work that estimates the percent of participants in clinical trials responding positively to specific interventions. While a number of treatments have not yet yielded reliable estimates of percent of responders, many have, and inclusion of them in this summary table enables readers now to know both whether an intervention meets empirically supported treatment standards and, if it does, what percent of patients have typically benefited from it in clinical trials. As an interdisciplinary work that integrates information from both clinical psychology and psychiatry, this new edition will continue to serve as an essential volume for both academics and practicing clinicians.