Enzyme Inhibition in Drug Discovery and Development : The Good and the Bad
ISBN: 9780470281741 | 047028174X
Edition: 1stFormat: Hardcover
Publisher: Wiley
Pub. Date: 1/7/2010
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The science and applied approaches of enzyme inhibition in drug discovery and developmentOffering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development.With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of ... MORE
| Preface | p. ix |
| Contributors | p. xi |
| Drug Discovery Approaches and Technologies | p. 1 |
| The Drug Discovery Process | p. 3 |
| Medicinal Chemistry of the Optimization of Enzyme Inhibitors | p. 15 |
| Bioanalytical Technologies in Drug Discovery | p. 43 |
| Safety Biomarkers in Drug Development: Emerging Trends and Implications | p. 71 |
| The Role of Drug Metabolism in Drug Discovery | ... MORE |
| Applied Pharmacokinetics in Drug Discovery and Development | p. 177 |
| Inhibition of The Drug Metabolizing Enzymes-The Undesirable Inhibition | p. 241 |
| Enzyme Inhibition and Inactivation: Cytochrome P450 Enzymes | p. 243 |
| Cytochrome P450 Induction | p. 265 |
| Inhibition of Drug-Metabolizing Enzymes in the Gastrointestinal Tract and Its Influence on the Drug-Drug Interaction Prediction | p. 315 |
| Enzyme Inhibition in Various In Vitro Systems | p. 345 |
| Cytochrome P450 Degradation and Its Clinical Relevance | p. 363 |
| Complexities of Working with UDP-Glucuronosyltransferases (UGTs): Focus on Enzyme Inhibition | p. 407 |
| Evaluation of Inhibitors of Drug Metabolism in Human Hepatocytes | p. 423 |
| Grapefruit Juice and Its Constituents as New Esterase Inhibitors | p. 443 |
| Transporter-Xenobiotic Interactions: An Important Aspect of Drug Development Studies | p. 467 |
| Polymorphisms of Drug Transporters and Their Clinical Implications | p. 503 |
| Clinical Drug Interactions Due to Metabolic Inhibition: Prediction, Assessment, and Interpretation | p. 533 |
| Predicting Interindividual Variability of Metabolic Drug-Drug Interactions: Identifying the Causes and Accounting for Them Using a Systems Approach | p. 549 |
| Inhibition of The Drug Target Enzymes-The Desirable Inhibition | p. 569 |
| NF-kB: Mechanism, Tumor Biology, and Inhibitors | p. 571 |
| G-Protein-Coupled Receptors as Drug Targets | p. 625 |
| Pharmacological Modulation of Ion Channels for the Treatment of Chronic Pain | p. 669 |
| Targeting the mTOR Pathway for Tumor Therapeutics | p. 719 |
| HIV-1 Protease Inhibitors as Antiretroviral Agents | p. 749 |
| Index | p. 811 |
| Table of Contents provided by Ingram. All Rights Reserved. |
Chuang LU, PHD, is the Associate Director in the Drug Safety and Disposition Department of Millennium Pharmaceuticals. His current research interests include drug-metabolizing enzymes, drug-drug interaction, and in vitro-in vivo correlation. Albert P. LI, PHD, is the President and CEO of In Vitro ADMET Laboratories, LLC and Advanced Pharmaceutical Sciences, Inc., and the cofounder, Chairman, and CSO of the ADMET Group. His experience spans over twenty-five years in the drug development industry, with over 150 publications. He is the editor of several books, including Drug-Drug Interactions in Pharmaceutical Development, published by Wiley.
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