Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates. Computer-Aided Vaccine Design is a comprehensive introduction to this exciting field of study. Computer-Aided Vaccine Design is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. The book is of interest to computational biologists who would like to understand more about the biological concepts related to the field of computational immunology.